Modern Drug Discovery ACS Publications
January 2004 From Concept to Development
MDD home
Volume 7, Issue 1
Article Indexes
Author Indexes


Assaying ADMET (163 KB)
by Mark S. Lesney
In pharmacology and drug development, the research paradigm of adsorption, distribution, metabolism, excretion, and toxicity (ADME/Tox or ADMET) studies helps determine dosage and toxicity for new drugs before human trials. An automation-friendly solution is the use of human-cell-based assays for ADMET parameters.

Assaying ADMET

Liposomes: The next generation (171 KB)
by Haris Jamil, Saifuddin Sheikh,
and Imran Ahmad
New advances in liposomal technology are combining drugs or other compounds in unique lipids to create stable liposomes. Such formulations are designed with the goal of producing small and homogeneous drug particles with simple, easy-to-use liquid or lyophilized products.

Liposomes: The next generation

The potential of preform (172 KB)
by Peter J. Desrosiers
A new high-throughput preformulation workflow allows crystallization, salt selection, and polymorph studies to be completed in less time and with smaller quantities of active pharmaceutical ingredient than conventional studies. Two key features of this workflow are a substrate that eliminates the need for manual adjustment of crystals and the ability to use multiple analytical techniques.

The potential of preform


Content in Context
The next new thing (28 KB)
by James F. Ryan

News in Brief (128 KB)
Patch over pill? • Modeling medicine • PSA the Raman way • Promiscuous pharma • Split-pool mass spec • Anthrax vaccine contract • Surrogate signs for SLE? • Malarial prophylaxis problem

The Business Page (55 KB)
Marketplace, deals, and people

The Executive Interview
Greg Lucier, CEO, Invitrogen
(57 KB)
Interviewed by James F. Ryan
and Felicia M. Willis
“I always wanted to mesh technology with business.”

For Your Health
Left in knots
(181 KB)
by Randall C. Willis
New treatments might keep inflammatory bowel disease from being a debilitating disorder.

The Time Line
The ghosts of pharma past (72 KB)
by Mark S. Lesney
Companies that were once household names can vanish—hidden or dissolved in mergers and acquisitions.

Applications NoteBook
Screening for pharma gold
(97 KB)
by John Lynch
Researchers are using membrane technologies for high-throughput ADME analysis.


Sites and Software
Picture perfect
(82 KB)
by Janet L. Smith
To facilitate analysis, researchers are enlisting an image informatics solution for high-content screening.

The Tool Box
Identifying biowarfare agents
(78 KB)
by Thomas Gluodenis and Craig Kunitsky
Automated analysis of fatty acid methyl esters helps prevent bioterrorism.

Rules and Regulators
The FDA’s generic “Final Rule”
(74 KB)
by Lee A. Goldberg and Nadine Farid
These Hatch–Waxman reforms seek balance.

Ready to Read (93 KB)

  • Designs for Life
    Reviewed by Mark S. Lesney
  • Burger’s Medicinal Chemistry
    Reviewed by George B. Kauffman

On the Calendar
LabAutomation 2004
(68 KB)
The ALA’s annual show has a new California home.

The Word Puzzle
Genetic miscellany (37 KB) | Solution (html)
by Mark S. Lesney

Product Info Now (html)

Diseases and Disorders
Mucopolysaccharidosis I
(56 KB)
by Randall C. Willis