The Voyager Microwave Flow-Through Synthesis System offers options for handling
solids, slurries, and highly viscous fluids. Two separate flow-through modules
are designed to handle the entire range of scale-up applications.
The Voyager CF (Continuous Flow) module is the choice for scaling up solution-based
chemistries, while the Voyager SF (Stop Flow) module (pictured above) is the option
for scaling up chemistries with solid reagents, highly viscous materials, or insoluble
products. Both modules allow the automated scale-up of chemistries with microwave
energy, all with a completely safe, self-monitored platform. The SF option allows
for the synthesis of up to 50 mL of material automatically, giving chemists all
of the safety advantages of the Voyager flow-through design while yielding the
productivity and solids compatibility found with static batch systems.
As part of the Discover family of microwave synthesis products, Voyager can
handle single, small-scale reactions as well as scale-up to kilogram quantities.
The system also can perform atmospheric and pressurized reactions, and it has
temperature and pressure feedback control.
The use of active flow cells allows the user to suspend reagent beds in the
flow stream. These solid reagent beds can consist of immobilized reagents, catalysts,
scavengers, or coupling enhancers. Active flow cells can be prepared by users
for maximum versatility.
The Veloce micro parallel liquid chromatography (mPLC) system provides increased
sample analysis capacity to scientists who need information to make timely research
decisions. It uses established HPLC techniques, integrating them with conventional
laboratory workflow to increase time and cost efficiency. The Veloce system is
designed for fast, high-quality sample analysis in analytical chemistry, specifically
in the drug discovery and development process.
The features of the Veloce system include increased sample analysis capacity
and the ability to generate chromatograms comparable to those produced by conventional
HPLC instrumentation for a broad class of analytical chemistry applications. The
Veloce system provides up to 24 simultaneous separations. This parallel analysis
provides the ability to analyze a large number of compounds simultaneously, generate
a standard curve, and increase the number of replicates or conditions used in
a study.
At the heart of the Veloce system is the 24-column Brio cartridge, which enables
multiple samples to be analyzed in parallel for increased throughput. The cartridges
can incorporate columns of varying lengths and a range of stationary phases. Researchers
can select cartridges to fulfill throughput and to optimize performance for specific
experimental protocols. Because the Veloce system is similar to traditional HPLC
systems, scientists can continue to use their existing processes and protocols.
MultiScreen Caco-2 Assay Plates enable high-throughput ADME analysis of potential
drug targets. The 96-well plate design allows for aseptic handling and automated
permeability measurements. The MultiScreen Caco-2 Assay System includes growth
plates, feeding tray, and transport analysis plate for complete growth through
analysis in one plate. Millipore - www.millipore.com
Catalysts.
VERTEC organo-titanates are effective and adaptable catalysts for esterification
reactions of all types. They are used in the production of plasticizers, acrylates,
polycarbonates, specialty esters, unsaturated polyesters, and amides. The wide
selection of standard VERTEC organo-titanates fits most applications, but custom
formulations can be made for specific requirements. Alfa Aesar - www.alfa.com
Microcapillary cytometry.
The EasyCD4 system, which incorporates proprietary microcapillary cytometry technology,
provides results equivalent or superior to established flow cytometry and manual
microscopy methods of CD4 enumeration. The instrument is compact and portable
and does not require large volumes of sheath fluid or a dedicated laboratory infrastructure.
Operation is simple, maintenance is minimal, and the system is suitable for use
in pediatric as well as adult patients. Guava Technologies - www.guavatechnologies.com Booth no. 2610@DDT 2004
Screw-top tube.
The ScrewTop TrakMates tube is the first 8 X 12 format screw tube and rack on
the market. It features a permanently attached, globally unique 2D bar code. Good
for temperatures down to –178 °C, each tube can now be linked to a database
containing its contents for secure sample tracking. Matrix Technologies
- www.matrixtechcorp.com Booth nos. 2411, 2412@DDT 2004
Brochure.
This 12-page booklet describes the SterilGARD III Advance Class II, Type A2 biological
safety cabinet. The brochure includes information on cabinet ergonomics, performance,
ease of use, and serviceability. The streamlined design simplifies sealing for
pressure leak testing or cabinet decontamination. Plenum technology offers quieter
performance and extended HEPA filter life. Baker - www.bakerco.com
Vectors.
Living Colors pIRES2-DsRed-Express Vectors can identify mammalian cells expressing
a gene of interest by selecting red fluorescent cells. They contain the internal
ribosome entry site (IRES) of the encephalomyocarditis virus (ECMV), which permits
both the gene of interest and the DsRed-Express coding region to be translated
from a single mRNA. Selected cells or cell populations can be used directly in
assays, eliminating variability due to transfection efficiency. BD Biosciences
- www.bdbiosciences.com Booth no. 1516@DDT 2004
Gene targets.
The ASCENTA System provides a way to assess, prioritize, and qualify gene targets
expressed and regulated across a broad range of human diseases and animal model
systems. Containing gene expression data from over 8000 human, rat, and mouse
tissues, specific sample sets are directly relevant to the key therapeutic areas
of inflammation, oncology, central nervous system disorders, cardiovascular disease,
and metabolic disease. Gene Logic - www.genelogic.com Booth no. 1916@DDT 2004
Library
production.
Normalized cDNA libraries are produced from custom cDNA libraries (i.e., standard
libraries, microquantity libraries, etc.), with greater numbers and lengths of
high-quality clones generated in less time while substantially reducing abundant
genes. Standard, nanoquantity, and subtracted cDNA libraries are also offered,
as are total RNA purification from tissue, mRNA purification from tissue, mRNA
purification from total RNA, and cDNA library amplification. All libraries feature
directionally cloned cDNA for expression, antibody screening, subtraction, and
normalization. Express Genomics - www.express-genomics.com
Portable
pipettor.
The Cellmate II portable serological pipettor is powered by a lithium ion battery
with a lifetime guarantee. Available in five colors, the CellMate II includes
a table stand, wall mount, universal power supply, and plug adapters for international
use. Large aspirate and dispense triggers offer a comfortable finger platform
and allow precise control of liquid manipulations. A large backlit LED monitors
battery charge and pump speeds for both aspiration and dispense. Matrix
Technologies - www.matrixtechcorp.com Booth nos. 2411, 2412@DDT 2004
Image
software.
The Spot Detector BioApplication is a general-purpose image analysis software
module that performs rapid detection of spotlike targets in cells. Sophisticated
detection methods and optimized speed enhance Spot Detector’s analysis of
Norak’s Transfluor technology, providing quick evaluation of GPCR activation
and internalization via -arrestin
redistribution. With Spot Detector’s easy-to-use protocols and Transfluor
technology’s minimal plate preparation requirements, the user can easily
develop assays and perform screens for GPCR targets of interest. Cellomics
- www.cellomics.com Booth no. 2903@DDT 2004
Syringe
filters.
Millex Sample Preparation syringe filters with low-protein-binding Durapore membranes
are optimized for preparing 10 to 100 mL of protein-containing aqueous and mild
organic solutions. The 33-mm syringe filters have almost 20% greater surface area
to deliver faster flow rates and higher throughput. The units also have an operating
pressure of 100 psig (10 bar) that allows solutions to be filtered rapidly. The
filter units are available in 0.20- and 0.45-µm pore sizes. Millipore
- www.millipore.com
PCR analyzer.
The THEQ LifeCycler series offers a combination of server and workstation modules;
its virtual networking capabilities allow for individual PCR workload definition
with efficient centralized operation. Users can implement their own flexible PCR
solutions to meet individual requirements. THEQ is available in three block styles:
96- and 384-well PCR plates and 0.2- and 0.5-µL individual tubes. All systems
are robot-compatible format for integration into THEONYX lab automation systems. MWG Biotech - www.THE-MWG.com Booth no. 2704@DDT 2004
Automation bundle.
The 2D-FAB is a unique bundle for flexible, two-dimensional chromatography or
simple small-volume fractionation. This front-end automation bundle includes FractPAL
with software, a biocompatible Rheos binary pump for normal or microflow, and
an Eksigent NanoLC pump with no flow-splitting. The system is a highly transparent
two-step approach to multidimensional LC. LEAP Technologies - www.leaptec.com Booth no. 2702A@DDT 2004
PCR.
The FastStart High Fidelity PCR System combines FastStart Taq DNA Polymerase and
a thermostable proofreading protein to yield fourfold higher fidelity with hot-start
PCR. In addition to reducing errors in applications such as cloning, this blend
produces higher yields of the amplicon and minimizes nonspecific fragments. Roche - www.roche-applied-science.com/pcr Booth no. 2809@DDT 2004
Ligands.
BoPhoz ligands are ideal for many asymmetric reduction applications. The
unique phosphine–aminophosphine substructure of the BoPhoz ligands
imparts attributes not commonly found in other chiral catalysts, including shelf
stability, scalability, and high activity and enantioselectivity. BoPhoz
ligands are offered from stock in standard 0.1- and 0.5-g units for trial use. Alfa Aesar - www.alfa.com
Immunodiagnostics.
Colloidal Gold for immunodiagnostic labeling offers homogeneity of particle size
and shape to increase long-term stability and minimize nonspecific binding of
the gold conjugate. Featuring a 40-nm particle size at 520–525 nm (OD), Colloidal
Gold provides flexibility for use in pregnancy, infectious disease, drug-of-abuse,
agricultural-based, and other rapid assays. For validation, test developers and
manufacturers can evaluate 3 lots of material provided in 100- , 500- , or 1000-
mL bottles. Schleicher & Schuell BioScience - www.schleicher-schuell.com/bioscience
Software.
Clintrace 4.0 streamlines administrative functions and overhead by providing safety
personnel at pharmaceutical and biotechnology companies with a scalable, browser-based,
centrally administered, and easy-to-use solution for adverse-event tracking and
reporting. Clintrace 4.0 electronically links all safety personnel, including
CROs, partners, and affiliates, to speed adverse event processing. It lowers IT
expense through Web-based software that is easy to install, maintain, and support. Phase Forward - www.phaseforward.com
Neuropeptide antibodies.
Antibodies to the neuropeptides Rab3a, synaptosomal-associated protein of 25 kDa
(SNAP25), synapsin, and synuclein are available. These antibodies complement other
neuropeptide antibodies such as -amyloid,
-
enolase, neuron-specific enolase, glial fibrillary acidic protein (GFAP), neurofilament,
tangles, and PHF-tau. Pierce Biotechnology/Endogen - www.endogen.com Booth no. 2010@DDT 2004
Protein.
BD Matrigel Matrix, High Concentration (HC), is now available from BD Biosciences
Discovery Labware. BD Matrigel Matrix is a solubilized basement membrane preparation
extracted from EHS mouse sarcoma, a tumor rich in ECM proteins. Its major component
is laminin, followed by collagen IV, heparan sulfate proteoglycans, and entactin.
BD Matrigel Matrix, HC,is used for in vivo angiogenesis assays and to augment
the growth of human tumors in nude mice. BD Biosciences - www.bdbiosciences.com Booth no. 1516@DDT 2004
Microplates.
The Zero-Trap series of 96- and 384-well microplates features novel proprietary
surface treatment technology. This coating process reduces nonspecific binding
of proteins, peptides, nucleic acids, and lipophilic small molecules to the microplate
during assays. It can be applied to virtually any micro well plate including polystyrene,
polypropylene, polycarbonate, and glass. The hydrophilicity of the Zero-Trap surface
has the added benefit of permitting accurate and precise dispensing and mixing
of small volumes of aqueous solutions. NoAb BioDiscoveries - www.noabbiodiscoveries.com
Purifier.
The APS-2000 purification systems provide compound isolation and high-throughput
purification for the pharmaceutical, chemical, and life science industries. They
are ideal for crude synthesis products, reference materials, and compounds from
natural product extracts. The APS-2000 systems are available in configurations
supporting UV-, MS-, and ELSD-based fraction collection. Dionex - www.dionex.com
Catalog.
The 2003/2004 Organics, Inorganics, Metals and Materials Catalog includes
the entire range of Avocado Organic compounds. This edition carries over 20,000
products, including organic compounds, high-purity inorganics, pure metals, alloys,
elements, precious metal compounds and catalysts, rare earths, AA/ICP standards,
precious metal labware, and more. For a free copy, call 1-800-343-0660 or 1-978-521-6300
(outside the U.S.A.). Alfa Aesar - www.alfa.com
HPLC
mobile phases.
CHEM+ NECT packaging technology provides a disposable, closed-system alternative
to the traditional and potentially hazardous preparation of HPLC mobile phases.
These premixed mobile phases are manufactured to customer specifications using
reagent-grade components to ensure equivalent performance, and they can be easily
connected to any HPLC system. CHEM+NECT solutions are also offered with stability
data to validate long-term consistency. CHATA Biosystems - www.chatabio.com
Online
platform.
The Celera Discovery System online platform is a subscription-based, integrated
research platform that provides online access to the most comprehensive and current
set of curated biological data and analysis tools available for comparing human
and mouse genomes. The platform includes an interactive, customizable Map Viewer
that provides graphical displays for comparing human and mouse genes within their
genomic contexts. Applied Biosystems - www.appliedbiosystems.com
Cycloamylose refolding.
The Refolding CA Kit provides a two-step procedure that optimizes the refolding
conditions of inclusion body proteins. This optimization results in a high refolding
efficiency for restoration of protein activity. The kit is supplied with guanidine
hydrochloride and DTT for protein unfolding, four different surfactants that can
be added independently to the unfolded protein solution to provide protection
against molecular aggregation, and highly polymerized cycloamylose for surfactant
removal and recovery of protein activity. Reagents are provided for 25 refolding
reactions (0.24 mg of protein per reaction). Takara Mirus Bio - www.takara.com
Software.
Varia is designed for researchers involved in high-volume genetic analysis. Features
include navigable displays of the complete human genome at the nucleotide scale,
algorithms for identifying regions of autozygosity, automated tools for building
haplotype maps and constructing pedigrees from genotype data, and linkage analysis
tools for the assocation of variation-to-variation or variation-to-disease. Silicon Genetics - www.silicongenetics.com
Platform.
The Certified ArrayScan Platform is equipped with an integrated solution featuring
a preowned Certified ArrayScan HCS Reader equipped with a suite of BioApplications
image analysis algorithms for comprehensive multiparametric assay capability.
Rich cellular data is managed automatically by a complete range of HCS informatics
tools. The Certified ArrayScan promotion is a low-cost solution for accessing
high-content biology. Cellomics - www.cellomics.com Booth no. 2903@DDT 2004
Software.
The ActiveSite software add-on to the BioCAChe, BioMed-CAChe, and WorkSystem Pro
products provides powerful tools to speed the drug discovery process by allowing
researchers to predict and select better-quality leads before making them in the
laboratory. Scientists can import and display 3D proteins directly from the Protein
Data Bank and then view, analyze, and modify them by using interactive sequence
and 3D structure editor windows. Users also can optimize proteins, dock ligands,
and model reactions of molecules with tens of thousands of atoms. CAChe
Group - www.cachesoftware.com Booth no. 2502@DDT 2004
Dispenser.
The WellMate is a high-speed, small-footprint, 8-channel fluid dispenser for 96-
and 384-well microplates. It features a height-adjustable dispense head to accommodate
dispensing to shallow- and deep-well plates and blocks; low-cost, disposable,
presterilized tubing cartridges that enable dispense volumes of 2.0–2000
µL; programmability in 1.0-µL increments; memory for storing as many
as 18 dispense protocols; and a digital keypad. RS232 programming promotes robotic
integration, and a removable plate stage makes cleaning fast and easy. Matrix
Technologies - www.matrixtechcorp.com Booth nos. 2411, 2412@DDT 2004
Autosampler.
The Sample Sentinel refrigerated unit offers robotic liquid-chromatographic autosampling
by moving the sample vial to sampling, diluting, or mixing stations without requiring
complex mechanical drivers. Capable of transferring 105 vials (300 µL or
1.8 mL) in three removable trays when cooled or 120 vials when uncooled, the unit
is designed for use with microbore, standard-bore, or preparative applications
and is available for precise fixed-loop and variable-loop injection. With the
sample preparation option, up to three reagent additions are programmable. BASi - www.bioanalytical.com
Solid
reagent option for microwave flow reactor
Micro
parallel LC system
Assay
plates. 
Library
production. 
Portable
pipettor. 
Image
software. 
-arrestin
redistribution. With Spot Detector’s easy-to-use protocols and Transfluor
technology’s minimal plate preparation requirements, the user can easily
develop assays and perform screens for GPCR targets of interest.
Syringe
filters. 
Software.
-
Protein.
HPLC
mobile phases. 
Online
platform. 
Software.
Autosampler.