PDF
version(240 KB PDF)
Metabolic profiling provides functional information at the biochemical level that
can be used to see what pathways and mechanisms are altered by specific interventions
or diseases. Thus, pharmaceutical and biotechnology scientists are investing a
lot of time and resources into developing new tools and techniques to identify
metabolic markers that will explain disease pathogenesis and/or serve as biochemical
signposts during preclinical and clinical drug screening.
PDF
version(224 KB PDF)
The prospect of performing clinical trials in which the analysis of safety or
efficacy is put in the context of genetic or genomic subgroups, or in which patients
are stratified on the basis of this type of data, is still uncertain, as is the
outlook for making the resulting data available to regulatory agencies and the
public. But signs are becoming more evident that opportunities for integrating
pharmacogenomics, the science of linking genetic determinants to drug response,
into clinical research are on the rise.
Sites and Software Pharma
and the seven keys(72 KB PDF)
by Randall C. Willis
Over the next decade, critical informatics technologies will revolutionize the
drug industry.
The Tool Box Addressing
“the three Rs”(76 KB PDF)
by Christina Burtsoff Asp
Microfluidics can help reduce the number of animals used in research and preclinical
studies.
New
and Noteworthy(152 KB PDF)
HIV vaccine testing Leave a message Lithium and AD BioShield
strikes back? Structural alliances Tigecycline trials Riding
the nanotube Measuring immune-response memory
Warning,
merge with care: Sanofi-Aventis(84 KB PDF)
by Kimberly S. Cleaves and Ann M. Thayer
A near-shotgun marriage for France’s two largest pharmaceutical companies.
Decommissioning
knowledge silos(84 KB PDF)
by Randall C. Willis
To succeed, R&D, clinical, and marketing departments must see each other as
assets.
Honoring
Syntex’s “Big Three”(68
KB PDF)
by Bryan D. Tweedy
The trio of scientists involved in the development of oral contraceptives receives
awards.
Diseases and Disorders New
drugs hold promise for osteoporosis(80 KB PDF)
by Linda Richards
Although a potentially debilitating disease, with treatment it can be prevented.
Rules and Regulators The
NIH “swivel chair”(72 KB PDF)
by David Filmore
The Health and Human Services agency’s conflict-of-interest policies are under
heavy scrutiny.
Applications Notebook From
the laboratory to the patients(168 KB PDF)
by Nadine Pavloff
Strategies for the rapid development of cell-culture manufacturing processes for
human enzymes