The CompareIt application has been added to version 4.1 of the KnowItAll Informatics
System. Pharmaceutical researchers can use this tool to visualize and compare
numeric data between multiple databases. In pharmaceutical research, comparisons
are regularly needed across different research data sets in order to compare predicted
values with experimental laboratory results and visualize the relationships between
different experimental values between data sets.
Using the CompareIt application, users can select any two property fields from
multiple databases for comparison. For example, a researcher might choose to compare
ADME response data (e.g., bloodbrain barrier) to molecular physical property
data (e.g., polar surface area, logP, etc.) or to other ADME response data (e.g.,
human intestinal absorption).
Once the researcher selects the fields to be compared, the CompareIt application
generates a scatter-plot diagram of one variable versus the other. Selecting any
point or group of points will immediately display the compounds associated with
that record, with an easy pop-up view of all the data associated with the compound.
From this scatter-plot comparison, the researcher can visualize trends and segregate
data that follows a desired trend from that which does not.
The data input for this application can be either KnowItAll user-generated
or reference databases containing experimental data, calculated results, or both.
The CompareIt application is fully integrated with all other applications in the
KnowItAll environment, including searching, reporting, and prediction.
The small-volume end-ported BioProcess Container (BPC) systems applications
include QC sampling, product storage, and delivery and collection of cells, process
fluids, and final product. These flexible containers demonstrate tensile properties,
low gas permeability, a low profile of leachable compounds, and a product contact
surface free of animal-derived components. These products are available in sizes
ranging from 50 to 2000 mL and can be customized with a variety of end connectors,
fluid paths incorporating sterile filters, and manifolds. HyClone - www.hyclone.com
Precision pump.
The milliGAT pump for precision fluid handling bidirec-tionally pumps both liquids
and gases, or a combination of both. It features a flow range of over 6 orders
of magnitude, from nL/min to mL/min, and its capability to meter volumes as small
as nanoliters makes it suitable for many applications, including microfluidics,
HTS, dispensing, titrating, FIA, SIA, and diluting. The milliGAT features pulseless
flow and 100-psi backpressure; has no check valves; and is self-priming, chemically
inert, stepper-motor-driven, and fully computer-control-lable. Global FIA
- www.globalfia.com
Control software.
Special control software for the EZChrom Elite Chromatography Data Systems
and the OpenLAB Laboratory Software Framework is available to control the Varian
3900 GC from Varian Instruments Associates. This software allows EZChrom Elite
or OpenLAB to fully control the 3900 GC with instrument control of the GC and
related autosamplers. Software control of the 3900 GC allows users to create a
single software method to provide data analysis and reporting as well as control
of instrument running conditions. Data from the detector is collected and analyzed
with a full range of reporting options. The control software supports instrument
parameters such as split/splitless mode, multiple on-column injectors, inlet temperature
control, column oven temperature, FID and TCD detectors, and other important 3900
GC settings. Scientific Software - www.scisw.com
Atomic models.
Offered under license from the American Society for Biochemistry and Molecular
Biology, these CPK, three-dimensional atomic models can be assembled, disassembled,
and reassembled easily using simple construction tools. The models are offered
in three different ways: as individual atomic models, connectors, and accessories;
as sets for construction of specific molecules; and as assembled molecular structures,
for example, amino acids, purine nitrogen bases, pyrimidine nitrogen bases, purine
nucleosides, fatty acids and derivatives, enzyme cofactors, water- and fat-soluble
vitamins, and many more. Harvard Apparatus - www.harvardapparatus.com