2003 Article Index

Features
Gene therapy: Hope in a cautionary tale. Mark S. Lesney. January
Monitoring microbes. Randall C. Willis. January
Scanning the code for combichem. Kevin Braeckmans, Joseph Demeester, Stefaan C. De Smedt, Marc Leblans, Rudi Pauwels, Chris Roelant. February
The virtual patient. Randall C. Willis. February
MS and microbiology. Catherine C. Fenselau, Kathryn Jackson. March
Charting the bureaucracy of life. Mark S. Lesney. March
The anatomy of metabolism. Mark S. Lesney. April
Imaging: Portraits from life. Nancy K. McGuire. April
Focus on phosphate. Mark S. Lesney. May
SPRing screening. Stefan Lofas. May
Chirality in a combinatorial age. David Filmore. June
A knockouts tale. Mark S. Lesney. June
Playing the protein polyphony. Mark S. Lesney. June
Pharmacogenomics: Looking toward the payoff. Mark S. Lesney, Randall C. Willis. July
Therapeutic interference. Charles Schmidt. July
Fluorescent protein biosensors. Yih-Tai Chen, Kenneth A. Giuliano, Jeffrey R. Haskins. August
NMR on target. Mark Kelly, Daniel Sem, Hugo Villar. August
Gearing up for speedy relief. Mark S. Lesney. August
Keeping an (infrared) eye out. David Filmore. September
Drawing out drugs. Nancy Ogihara. September
Therapeutic antibodies. Michael Braunagel, Bjorn Cochlovius, Martin Welschof. October
Maryland: "Free State" or Bio State? Felicia M. Willis. October
The puzzle of the proteome. Randall C. Willis. October
CD Simplicity. Michael J. Felton. November
HIV therapy—out of balance. Mark S. Lesney. November
Moving with BioMEMS. Nancy K. McGuire. November
The cellular solution. Mark S. Lesney. December
Aiming at apoptosis. Mark S. Lesney, Randall C. Willis. December
Uppsala: The biotech heart of Sweden. Felicia M. Willis. December

Applications NoteBook
HapMapping the genome. David Bradley. February
A thousand points of blue. Vicki L. Locke, Dennis B. Rylatt. April
The tablet's coat du jour. John T. Thornton. May
A matter of size. Randall C. Willis. June
In fine pharm. Kevin Altria. July
Pharmacological profiling. Veronique Timmermans. August
Measuring modifications. Randall C. Willis. October
Fingerprinting the unusual. David Bradley. December

Clinical Trials Track
Gene therapy revisited. Mark S. Lesney. March
Kinase inhibitors. Mark S. Lesney. May
Monoclonal en masse. Mark S. Lesney. July
RECIST is not futile. Mark S. Lesney. November

Content in Context
Dick and Gene? James F. Ryan. January
Agincourt. James F. Ryan. February
You can't always get what you want. James F. Ryan. March
Art, elegance, and the helix. James F. Ryan. April
SARS wars. James F. Ryan. May
Maps and models. James F. Ryan. June
Nomenclature. James F. Ryan. July
The new fluoridation? James F. Ryan. August
Spare me, HAL. James F. Ryan. September
Consumer Rx? James F. Ryan. October
Minirevolutions. James F. Ryan. November
Greetings and felicitations! James F. Ryan. December

Disease and Disorders
Rosacea. Christen L. Brownlee. January
Chancroid. Eric Whitemon. February
Urinary incontinence. Mary Anne Dunkin. March
Elephantiasis. Julie McDowell. April
Fragile X syndrome. Randall C. Willis. May
Chronic hiccups. Felicia M. Willis. June
Celiac disease. Nancy K. McGuire. July
Charcot-Marie-Tooth disease. Kimberly S. Cleaves. August
Antiphospholipid syndrome. Randall C. Willis. September
Hypothyroidism. Julia Belcher. October
Amebiasis. Felicia M. Willis. November
Alcoholism. Felicia M. Willis. December

For Your Health
A clockwork human. Felicia M. Willis. April
Caffeine chronicles. Mark S. Lesney. May
Tossing and turning. Julie McDowell. July
The question of pain. David Bradley. September
Are your shots current. Linda Richards. November

News in Brief
January: Single-cell genotyping • Cotton: The fabric of our libraries • Contracts don’t cut it? • Affecting a jaundiced view? • Building bones • Signaling cell death

February: Beneficial tea • Sense and markability • Back pain, all in the brain • ADHD and autism: Chromosomal connection? • Mass and metabolites • Cancer immunotherapy • Mice glow • Matching genes and substructures

March: Prognostic biomarker • Boronic β-lactamase busters? • mAb fuel • Crystallize to deliver • Computer dating for GPCRs • β-Amyloid binders • Nano-antidotes • Paring probes

April: Yeast of burden • Mesoporous medicine • Distal distortions, resistant HIV • Lupus solution? • A natural comparison • Gene machine glycobiology • Sloan-Kettering goes herbal •Drug ads

May: Combi-extensions • Protein chip • Eggs, not butter • FDA looks forward • Pox pill penetration • Interfering with HCV • Thiamine to tumor • Aspirin toxicity—NO way • Going with the flow • Chemical matchmaker

June: Fusion inhibitor approved • Pumping iron • The shorter the better • Loofa livers • Artificial glycoviral vectors • Penetrating the skin you’re in • Sample prep school • Particle size on the fly • Imaging with monoclonals • Changing peptide partners

July: Breast cancer and antioxidants • Toward a malaria vaccine • An adverse look • Lowering brain cholesterol •Slow GABA, and go? • Blood and gold • Glyco-boosting biomeds • Quantitative chemical proteomics • Cytotoxic targeting •SECM sensitivity

August: Automated knockouts • Triton trick • Estrogen and arthritis • Breast cancer marker? • Adlay allays • Greenhouse drug discovery • Just a hint of sugar • Meds Management

September: Intuition precedes computation • Combichem QC • GIP and glucose • What do the dimers do? • Protein patterning • Bacterial drug delivery • Talking AIDS and alternatives • Anti-asthma antibody

October: RNA—totally, tubular • Lytic peptides and cancer • Antibody Pool-EASE! • Biologics: Generically speaking • START in CA • Self-indicating synthesis • A web of health • Liver toxicity attention

November: Viral nanosensor • Liquid assets • The glycan can • Ramped-up screening • Fewer pills with prodrugs? • Microbicide trials • Inducible gene vectors • NC biotech from tobacco funds

December: Pinning a label • Animal-on-a-chip • Polymorphs in parallel • The soy matrix • Reducing mom-to-baby HIV transmission • Earlier is better, for MS • Biotech business • Natural products aMASSed

Ready to Read
Timebomb: The Global Epidemic of Multi-Drug-Resistant Tuberculosis. Mark S. Lesney. March
The Common Thread: A story of Science, Politics, Ethics, and the Human Genome. Eric Whitemon. July
The Road to Stockholm: Nobel Prizes, Science, and Scientists. Julie McDowell. August
The Deadly Truth: A History of Disease in America. Julie McDowell. December

Rules and Regulators
Medical meddling? Randall C. Willis. April
Pharma down PAT. Charles Schmidt. June
When the pills run out. Cullen T. Vogelson. August
Talking pharmacogenomics. David Filmore. October
Protecting privacy. Cullen T. Vogelson. December

Sites and Software
A Web of support. Nancy K. McGuire. March
E pluribus unum. Ludwig Franzisket. May
Scaling the heights of productivity. Peter Giannousis, Bill Nelson, James Tam. July
Learning for larger scales. David Filmore. September
The discovery gridiron. Chris Crafford. November

The Business Page
The Executive Interview: Bill Linton. Christen L. Brownlee, James F. Ryan. January
Patents and Property. David Filmore. February
Matters of money. Charles W. Schmidt. March
The Executive Interview: Lissa Goldenstein. Kimberly S. Cleaves, James F. Ryan. April
Patents and property. Joseph G. Contrera, Belinda M. Lew. May
Matters of money. Neil Canavan. June
The Executive Interview: Mike Collins. Kimberly S. Cleaves, James F. Ryan. July
Patents and property. David Filmore. August
Matters of money. Jennifer Dahlgren. September
The Executive Interview: Frank Laukien. Kimberly S. Cleaves, James F. Ryan. October
Patents and property. Donald J. Featherstone, Jorge A. Goldstein. November
Matters of money. Felicia M. Willis. December

The Time Line
Developing diuretics. Richard A. Pizzi. February
Watson and Crick—Beyond the double helix. Christopher S. W. Koehler. April
Desperately seeking quinine. Vassiliki Betty Smocovitis. May
"Magic" monoclonals. Richard A. Pizzi. June
Molds and maladies. Mark S. Lesney. August
The French connection. Richard A. Pizzi. October
A jaundice view. Mark S. Lesney. November
Yellow jack. Mark S. Lesney. December

The Tool Box
Membrane-based drug assays. Jeff Ruell. January
A work in process. Sam Nochumson, Tim N. Warner. February
On display. Kevin FitzGerald, Duncan McGregor. March
High (throughput) mass. David Bradley. April
From gene to protein. Burkhard Ziebolz. May
A measured solution. Alex Avdeef, Jeffrey Ruell. June
Ultracool NMR technology. Kimberly L. Colson. July
Pharma ex machina. Konstantin V. Balakin. August
A capillary idea. Kevin Altria. September
Altering the calcium landscape. Michael Tarquini. October
Arrays of possibilities. Ralph Martel. November
Pictures, puzzles, and patches. Adrzej Cholewinski. December