TABLE OF CONTENTS
February 21, 2000
Volume 78, Number 8
CENEAR 78 8 p. 1
ISSN 0009-2347

Quote of the Week

"We have encoded in our own genes the solutions to many diseases. What awaits is just a way to switch on those critical genes."

Carlos F. Barbas III, molecular biology professor, Scripps Research Institute

page 34


NEWS OF THE WEEK

NEW AT DOW:   5
Company veteran Michael Parker to be president and CEO.

SHAKEUP AT DUPONT:  5
One chief operating officer departs, leaving another chief operating officer of one year as second-in-command.

ANTIBIOTIC BOOST:   6
Compound from barberry plant inactivates bacterial pumps, allowing antibiotics to do their job.

SUN-DAMAGED SKIN FIX:   7
Enzyme from ocean plankton reverses dimerization of human DNA.

TiO2 ACQUISITION:   7
Kerr-McGee is acquiring two of Kemira's production units for $403 million.

FLUOROUS CATALYSIS:   8
Dendrimer-encapsulated palladium nanoparticles prove highly active, selective, recyclable.

MAMMOTH CRYSTALS:   8
World's largest fast-growth crystals have been prepared.

BUSINESS

BUSINESS CONCENTRATES: 9

PRICE FIXING:   11
Chemical makers have been a major target of recent Justice Department crackdowns on cartels.

TAIWAN'S SCINOPHARM:   15
Firm with high hopes for success is building a world-class complex.

GOVERNMENT & POLICY

GOVERNMENT CONCENTRATES:  17

COVER STORY

FEDERAL R&D BUDGET:   18
Funding is up for most agencies, with emphasis on interagency initiatives.

GOVERNMENT INSIGHTS:   25
Reporter pays homage to three people who did more than push the party line.

SCIENCE/TECHNOLOGY

SCIENCE/TECHNOLOGY CONCENTRATES:  26

NANOSCIENCE SCALES UP:   27
Research center in Germany aims to promote interdisciplinary research in nanotechnology.

PROTEIN-LIGAND BINDING:   30
New NMR-based technique shortens time to determine structures of protein-ligand complexes.

GENES ON, GENES OFF:   34
Designed proteins act like transcription factors to control genes in living cells.

ENZYME ACTIVITY TO GO:   35
British researchers modify a natural enzyme to order, giving it a new catalytic function.

EDUCATION

EDUCATION CONCENTRATES:  37

ACS NEWS

NANOSCIENCE AT ACS:   39
New subdivision provides a home for advanced materials, nanotechnology.

THE DEPARTMENTS

   2 LETTERS

   3 EDITOR'S PAGE

  40 PEOPLE

  42 AWARDS

  44 MEETINGS

  64 NEWSCRIPTS


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