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How to Advertise Cover Story WORLD CHEMICAL OUTLOOK Business CANADIAN FINE CHEMICALS Government & Policy INSIGHTS Science & Technology IMPROVING ON NATURE NATIONAL CHEMISTRY WEEK Table of Contents December 17, 2001 Volume 79, Number 51 CENEAR 79 51 p. 3 NEWS OF THE WEEK CORRECT SYNTHESIS, WRONG PRODUCT Scientists revise structure of natural product with anticancer properties. CHANGES AT NIH NCI gets a new head; NIH campus security is tightened even more. ROCHE EXPANDS IN JAPAN Swiss firm to acquire 50.1% of Chugai Pharmaceuticals. SACRIFICIAL BONDS Weak chemical bonds that readily break and re-form may make for tough bones. NSF CHEMISTRY DIVISION Wisconsin's Arthur B. Ellis is selected as new head. CHEMICAL PLANTS SHUT DOWN Chevron Phillips and Dow are closing ethylene crackers, other units. TRAVERSING CELL MEMBRANES Rapidly breaking and re-forming hydrogen bonds, H2O passes through. ACS BOARD ACTIONS Flint Lewis is chosen as next ACS secretary, budget is approved, and several new projects are funded. COVER STORY WORLD CHEMICAL OUTLOOK For the chemical industry, 2001 was awful; signs are slightly more optimistic for 2002. BUSINESS BUSINESS CONCENTRATES CANADIAN FINE CHEMICALS Unique multicultural environment, government and entrepreneurial support foster chemical industry. J. M. HUBER Firm acquires Finnish rheology modifier maker Noviant and expands its specialty chemicals business. GOVERNMENT & POLICY GOVERNMENT CONCENTRATES DOE AND NONPROLIFERATION U.S. waffling on issues and programs is having global repercussions. BIOTERRORISM House Science Committee wants to ensure that the U.S. invests in R&D needed to combat bioterrorism. INSIGHTS This Congress can't pass bills, lacks expertise to understand complex science legislation. SCIENCE/TECHNOLOGY SCIENCE/TECHNOLOGY CONCENTRATES IMPROVING ON NATURE Scientists use directed evolution to beef up enzymes' natural abilities. ROBERT BLACK C&EN talks with chemist whose inventions symbolize better living through chemistry. BOOKS SAFETY IN A HAZARDOUS WORLD ACS COMMENT WHAT IT MEANS TO BE AN ACS MEMBER ACS NEWS NATIONAL CHEMISTRY WEEK Across the U.S., chemical demonstrations and hands-on activities celebrate "Chemistry and Art." HISTORIC LANDMARK National Institute of Standards & Technology is named a historic chemical landmark on its 100th anniversary. THE DEPARTMENTS EDITOR'S PAGE LETTERS DIGITAL BRIEFS AWARDS PEOPLE NEWSCRIPTS

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