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Neglected Diseases
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Quote of the Week

"If the U.S. abandons its role of leadership in science and technology, there are others who will gladly step into that role."
RALPH L. MCNUTT JR., SPACE SCIENTIST, JOHN HOPKINS APPLIED PHYSICS LABp. 47

November 9, 2009

In This Issue:

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October 24, 2011 Issue
October 17, 2011 Issue
October 10, 2011 Issue
October 3, 2011 Issue

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Highlights

Cover Story

Partnering For Global Health

Drug companies and nonprofits are taking novel approaches to refill the pipeline of new drugs and vaccines for neglected diseases. (pp. 16-22)

Government & Policy

Politics, Money, And Climate (Member Content)

News Analysis: Copenhagen meeting is unlikely to produce a new climate-change treaty. (pp. 37-39)

Science & Technology

Chemistry Behind The Wall

Twenty years after the fall of the Berlin Wall, chemists who lived in former East Germany reflect on science then and now. (pp. 42-46)

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Table of Contents

News Of The Week

Old Drugs, New Tricks Clorox To Stop Using Chlorine Ironing Out Mercury's Makeup Japanese Earnings Surprise

Old Drugs, New Tricks p. 11

Polypharmacology: Ligand-based approach finds new targets of known drugs.

Clorox To Stop Using Chlorine p. 12

Plant Security: Bleach maker will end shipment of hazardous chemical.

OSHA Hits BP With Record Fine p. 12

Safety: $87 million penalty for violations, failure to comply with 2005 settlement.

Climate-Change Maneuvers p. 13

Legislation: Democrats push ahead as Republicans boycott markup meetings.

Pharma Strategy p. 13

Novartis makes major R&D and vaccines investments in China.

Light Commands Ion Channel p. 14

Chemical Biology: Photosensitive reaction opens or shuts potassium's flow.

Ironing Out Mercury's Makeup p. 14

Planetary Science: New results from spacecraft flyby show iron-rich surface.

Japanese Earnings Surprise p. 15

Fiscal First Half: Firms performed better than feared.

Environmental Scrutiny p. 15

EPA will assess impacts of black carbon and drilling chemicals for hydraulic fracturing.

Business

Solar On Sale pp. 28-30 (Member Content)

Photovoltaic prices will continue to drop, thanks to an oversupply of polysilicon.

Executive Upgrade pp. 32-33 (Member Content)

Technology management program receives high marks, but not all are pleased.

C&EN Talks With Peter Pollak p. 34 (Member Content)

A visionary in the fine chemicals industry claims a victory in a still-risky business.

Business Concentrates pp. 24-25 (Member Content)

  • J&J Revamps, Cuts Jobs
  • Johnson & Johnson is restructuring to improve its operating efficiency through more simplified processes and fewer layers of management...
  • DuPont Forecasts Strong Growth
  • As the global economic recovery gets under way, DuPont CEO Ellen J. Kullman predicts that her firm will deliver 20% compound annual earnings growth...
  • Dow Corning Gets Silicon Metal Plants
  • Dow Corning has bought one silicon metal plant and acquired an interest in a second one from Globe Specialty Metals in a $175 million deal...
  • Germany’s Merck Leads OLED Group
  • Merck KGaA is leading a new German consortium that aims to develop soluble materials to be used in large organic light-emitting diodes...
  • ExxonMobil, Toray In Battery film Venture
  • ExxonMobil Chemical’s Japanese affiliate and Japan’s Toray Industries are forming a 50-50 joint venture to develop and make separator films...
  • SGL And BMW Form Carbon Fiber Pact
  • The German carbon fiber maker SGL is forming joint ventures with automaker BMW and chemical maker Mitsubishi Rayon to make carbon fiber, the fiber’s precursor, and downstream fabric...
  • Mitsui And 
Sinopec Firm Up China Plans
  • Mitsui Chemicals and Sinopec plan to spend about $660 million in China to build new plants and acquire an existing one...
  • Lilly Opens Labs In California
  • In a move to advance its biotech drug pipeline, Eli Lilly & Co. opened a new biotechnology center in San Diego last week...
  • DSM Shelves China Vitamins Project
  • DSM has halted talks with North China Pharmaceutical Group about forming a vitamins and anti-infectives joint venture...
  • Carbogen Revamps Swiss Operations
  • The pharmaceutical chemicals firm Carbogen Amcis plans to restructure its three Swiss facilities in response to a decline in customer products in the early phases of drug development...
  • Archimica Makes Changes In Italy
  • Pharmaceutical chemical maker Archimica has sold its active pharmaceutical ingredient (API) plant in Isso, Italy, to the Italian firm Erredue...
  • Takeda Licenses Amylin Obesity Drugs
  • Takeda Pharmaceutical is licensing two obesity drugs in development at Amylin Pharmaceuticals...
  • Merck Closes On Schering-Plough
  • Merck & Co. completed its $41 billion acquisition of Schering-Plough last week...
  • Business Roundup
  • Cambrios, Equinox Chemicals, Lubrizol, Nalco, Celanese, China's Ministry of Commerce, GlaxoSmithKline and Pfizer, Biovitrum, Lonza...

Government & Policy

Politics, Money, And Climate pp. 37-39 (Member Content)

News Analysis: Copenhagen meeting is unlikely to produce a new climate-change treaty.

Government & Policy Concentrates p. 36 (Member Content)

People

Obituaries p. 49 (Member Content)

Science & Technology

Chemistry Behind The Wall pp. 42-46

Twenty years after the fall of the Berlin Wall, chemists who lived in former East Germany reflect on science then and now.

The Last of NASA's Fuel p. 47 (Member Content)

Reluctance to restart production of plutonium-238 could mean the end of deep-space exploration.

Digital Briefs p. 48 (Member Content)

New software and Websites for the Chemical Enterprise.

Science & Technology Concentrates pp. 40-41 (Member Content)

Editor's Page

Medicine And Climate p. 3

The Departments

Letters p. 4-9

Newscripts p. 56

Cardboard Scents, Splatter Science, Bear Break-Ins

This Week Online

C&EN Webinar

R-Group Virtual Screening: A New CADD Capability for Lead Optimization

C&EN Webinar on R-Group Screening

Join C&EN on November 19, 11:00 a.m-12:00 noon (EST), for a live webinar on R-Group Virtual Screening: A New CADD Capability for Lead Optimization, covering technology that provides new ideas and rank order based on existing information. Participants will learn about 3D QSAR that automates the creation of models for predicting the biological activity or properties of compounds, exceptionally fast 3D virtual screening for R groups based on both shape and pharmacophore similarity, and combining these technologies to find novel R-groups predicted to have high potency, optimize multiple parameters, and get hundreds of new, highly promising R-group ideas.

Register Free at http://pubs.acs.org/cen/webinar/

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