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Allosteric Drugs
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Quote of the Week

"If you've got a triglyceride or a sugar molecule, the government wants you."
DENNIS GRIESING, VICE PRESIDENT FOR GOVERNMENT AFFAIRS, SOAP & DETERGENT ASSOCIATIONp. 22

November 23, 2009

In This Issue:

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October 24, 2011 Issue
October 17, 2011 Issue
October 10, 2011 Issue
October 3, 2011 Issue

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Highlights

Cover Story

Allosteric Drugs

Agents binding at protein sites not used by natural ligands are getting renewed attention as therapeutics. (pp. 12-15)

Business

Breakthroughs In Spanish Biotech (Member Content)

PharmaMar and Genetrix score in a sector of reticent investors and business-resistant academics. (pp. 19-21)

Science & Technology

Hot Flashes: Still A Mystery (Member Content)

Researchers develop new treatments without fully understanding this common symptom of menopause. (pp. 33-35)

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Table of Contents

News Of The Week

ACS Election Results Chemicals Policy Scrutinized Ocean Alert Porous Balancing Act

Nancy Jackson Wins ACS Presidential Race p. 7

ACS News: Her year in the society's top spot will coincide with the International Year of Chemistry.

Dow In Sharp Focus p. 8

Business: Firm says it will invest more in high-growth, value-added chemistry.

Chemicals Policy Scrutinized p. 8

Safety: Stakeholders are divided over how sweeping changes to TSCA ought to be.

Ocean Alert p. 9

Climate Change: Earth's saltwater cover may be near its limit as a home for marine life and a sink for CO2.

Foreign Relations p. 9

U.S., China pledge to cooperate on greenhouse gas mitigation.

Porous Balancing Act p. 10

Zeolites: Method forms large pores without sacrificing small ones.

Giant Leap For Obstinate Targets p. 10

Sugar Chemistry: Parallel combinatorial synthesis yields 12 hard-to-make oligosaccharides.

Pharma Business p. 11

BMS is splitting off nutrition company to focus on biopharmaceuticals.

Business

Breakthroughs In Spanish Biotech pp. 19-21 (Member Content)

PharmaMar and Genetrix score in a sector of reticent investors and business-resistant academics.

Tall Challenge For Pine Chemicals pp. 22-23 (Member Content)

Clean energy legislation threatens industries based on renewable biomass.

Upscale Market Beckons pp. 24-25 (Member Content)

Lured by newly affluent consumers, international firms beef up drug manufacturing capabilities in China.

Business Concentrates pp. 16-17 (Member Content)

  • Genomics Pioneer deCode Goes Bust
  • Over a year into its attempts to revamp its business and reduce its debt, Icelandic firm deCode genetics has filed for bankruptcy...
  • Mitsubishi Chem Bids For Mitsubishi Rayon
  • In an anticipated move, Japan’s largest chemical company, Mitsubishi Chemical Holdings, has initiated a friendly bid to acquire all of the outstanding shares of Mitsubishi Rayon...
  • Olin Invests In Railcars For Bleach
  • Olin is developing a fleet of railcars designed to carry industrial bleach...
  • Honeywell To Build UOP Lab In India
  • Honeywell will spend $34 million to build a 400,000-sq-ft technology center at an existing Honeywell site in Gurgaon, India...
  • Sasol Mulls Gulf Coast octene Plant
  • Sasol says its Lake Charles, La., complex is a “leading candidate” as a location to build its first plant to use ethylene tetramerization technology to make α-olefins...
  • Mitsui Chemicals To Raise Capital
  • Mitsui Chemicals hopes to raise $720 million in new shares to help it cope with the downturn in the Japanese chemical industry and finance the construction of plants in China...
  • ZeaChem Constructing Cellulosic Biorefinery
  • Biofuel start-up ZeaChem has begun construction of a 250,000-gal-per-year cellulosic ethanol plant to test technology for a larger, commercial-scale biorefinery it is planning...
  • Suntech To Build Its First U.S. Plant
  • Chinese solar firm Suntech will build its first U.S. plant near Phoenix. The plant will have an initial capacity of 30 MW worth of solar modules per year...
  • Porifera Gains Desalination Technology
  • Membrane start-up Porifera has inked an exclusive licensing deal with Lawrence Livermore National Laboratory to develop carbon nanotube technology...
  • GSK Licenses Nabi’s Nicotine Vaccine
  • GlaxoSmithKline Biologicals and Nabi Biopharmaceuticals have signed an agreement that gives the GSK vaccines unit an exclusive option to in-license NicVAX...
  • Coca-Cola Launching Biobased Bottles
  • Coca-Cola says polyethylene terephthalate (PET) bottles incorporating sugar-derived raw materials are starting to hit store shelves...
  • Merck Cholesterol Drug Takes A Hit
  • Merck & Co.’s blockbuster cholesterol pill Zetia is less effective than an older, generic drug, according to a small clinical study...
  • Business Concentrates
  • Perstorp, CF Industries, Cognis, Genta, Eli Lilly & Co., FDA, UCB, Novartis, Emergent BioSolutions...

ACS News

Gains In Chemistry Grads Persist pp. 38-48 (Member Content)

Strong trend of rising bachelor's degrees continues, graduate awards slow.

ACS President Opens Dialogue With High School p. 49 (Member Content)

ACS, RSC Collaborate On Symposium p. 49 (Member Content)

Put Green Chemistry On The Map p. 49 (Member Content)

Government & Policy

Geoengineering Steps Toward Reality pp. 28-30 (Member Content)

Once viewed skeptically, plans for intentional intervention in earth's climate gain traction.

Lawmakers Consider Geoengineering Research Needs p. 30 (Member Content)

Government & Policy Concentrates p. 26 (Member Content)

ACS Comment

Chemistry Ambassadors: Minding The Gap And Filling It p. 37 (Member Content)

Science & Technology

Hot Flashes: Still A Mystery pp. 33-35 (Member Content)

Researchers develop new treatments without fully understanding this common symptom of menopause.

Inside Instrumentation p. 36 (Member Content)

Technology and Business news for the laboratory world.

Science & Technology Concentrates pp. 31-32 (Member Content)

Editor's Page

Inherently Safer p. 3

The Departments

Letters pp. 4-5

Newscripts p. 56

The Science And Smells Of Thanksgiving

This Week Online

C&EN Webinar

R-Group Virtual Screening: A New CADD Capability for Lead Optimization

C&EN Webinar on R-Group Screening

Join C&EN on November 19, 11:00 a.m-12:00 noon (EST), for a live webinar on R-Group Virtual Screening: A New CADD Capability for Lead Optimization, covering technology that provides new ideas and rank order based on existing information. Participants will learn about 3D QSAR that automates the creation of models for predicting the biological activity or properties of compounds, exceptionally fast 3D virtual screening for R groups based on both shape and pharmacophore similarity, and combining these technologies to find novel R-groups predicted to have high potency, optimize multiple parameters, and get hundreds of new, highly promising R-group ideas.

Register Free at http://pubs.acs.org/cen/webinar/

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