Allosteric Drugs
Quote of the Week
"If you've got a triglyceride or a sugar molecule, the government wants you."
DENNIS GRIESING, VICE PRESIDENT FOR GOVERNMENT AFFAIRS, SOAP & DETERGENT ASSOCIATION – p. 22
November 23, 2009
In This Issue:
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Highlights
Cover Story
Allosteric Drugs
Agents binding at protein sites not used by natural ligands are getting renewed attention as therapeutics. (pp. 12-15)
Business
Breakthroughs In Spanish Biotech (Member Content)
PharmaMar and Genetrix score in a sector of reticent investors and business-resistant academics. (pp. 19-21)
Science & Technology
Hot Flashes: Still A Mystery (Member Content)
Researchers develop new treatments without fully understanding this common symptom of menopause. (pp. 33-35)
Table of Contents
News Of The Week
Nancy Jackson Wins ACS Presidential Race p. 7
ACS News: Her year in the society's top spot will coincide with the International Year of Chemistry.
Dow In Sharp Focus p. 8
Business: Firm says it will invest more in high-growth, value-added chemistry.
Chemicals Policy Scrutinized p. 8
Safety: Stakeholders are divided over how sweeping changes to TSCA ought to be.
Ocean Alert p. 9
Climate Change: Earth's saltwater cover may be near its limit as a home for marine life and a sink for CO2.
Foreign Relations p. 9
U.S., China pledge to cooperate on greenhouse gas mitigation.
Porous Balancing Act p. 10
Zeolites: Method forms large pores without sacrificing small ones.
Giant Leap For Obstinate Targets p. 10
Sugar Chemistry: Parallel combinatorial synthesis yields 12 hard-to-make oligosaccharides.
Pharma Business p. 11
BMS is splitting off nutrition company to focus on biopharmaceuticals.
Business
Breakthroughs In Spanish Biotech pp. 19-21 (Member Content)
PharmaMar and Genetrix score in a sector of reticent investors and business-resistant academics.
Tall Challenge For Pine Chemicals pp. 22-23 (Member Content)
Clean energy legislation threatens industries based on renewable biomass.
Upscale Market Beckons pp. 24-25 (Member Content)
Lured by newly affluent consumers, international firms beef up drug manufacturing capabilities in China.
Business Concentrates pp. 16-17 (Member Content)
- Genomics Pioneer deCode Goes Bust
- Over a year into its attempts to revamp its business and reduce its debt, Icelandic firm deCode genetics has filed for bankruptcy...
- Mitsubishi Chem Bids For Mitsubishi Rayon
- In an anticipated move, Japan’s largest chemical company, Mitsubishi Chemical Holdings, has initiated a friendly bid to acquire all of the outstanding shares of Mitsubishi Rayon...
- Olin Invests In Railcars For Bleach
- Olin is developing a fleet of railcars designed to carry industrial bleach...
- Honeywell To Build UOP Lab In India
- Honeywell will spend $34 million to build a 400,000-sq-ft technology center at an existing Honeywell site in Gurgaon, India...
- Sasol Mulls Gulf Coast octene Plant
- Sasol says its Lake Charles, La., complex is a “leading candidate” as a location to build its first plant to use ethylene tetramerization technology to make α-olefins...
- Mitsui Chemicals To Raise Capital
- Mitsui Chemicals hopes to raise $720 million in new shares to help it cope with the downturn in the Japanese chemical industry and finance the construction of plants in China...
- ZeaChem Constructing Cellulosic Biorefinery
- Biofuel start-up ZeaChem has begun construction of a 250,000-gal-per-year cellulosic ethanol plant to test technology for a larger, commercial-scale biorefinery it is planning...
- Suntech To Build Its First U.S. Plant
- Chinese solar firm Suntech will build its first U.S. plant near Phoenix. The plant will have an initial capacity of 30 MW worth of solar modules per year...
- Porifera Gains Desalination Technology
- Membrane start-up Porifera has inked an exclusive licensing deal with Lawrence Livermore National Laboratory to develop carbon nanotube technology...
- GSK Licenses Nabi’s Nicotine Vaccine
- GlaxoSmithKline Biologicals and Nabi Biopharmaceuticals have signed an agreement that gives the GSK vaccines unit an exclusive option to in-license NicVAX...
- Coca-Cola Launching Biobased Bottles
- Coca-Cola says polyethylene terephthalate (PET) bottles incorporating sugar-derived raw materials are starting to hit store shelves...
- Merck Cholesterol Drug Takes A Hit
- Merck & Co.’s blockbuster cholesterol pill Zetia is less effective than an older, generic drug, according to a small clinical study...
- Business Concentrates
- Perstorp, CF Industries, Cognis, Genta, Eli Lilly & Co., FDA, UCB, Novartis, Emergent BioSolutions...
ACS News
Gains In Chemistry Grads Persist pp. 38-48 (Member Content)
Strong trend of rising bachelor's degrees continues, graduate awards slow.
ACS President Opens Dialogue With High School p. 49 (Member Content)
ACS, RSC Collaborate On Symposium p. 49 (Member Content)
Put Green Chemistry On The Map p. 49 (Member Content)
Government & Policy
Geoengineering Steps Toward Reality pp. 28-30 (Member Content)
Once viewed skeptically, plans for intentional intervention in earth's climate gain traction.
Lawmakers Consider Geoengineering Research Needs p. 30 (Member Content)
Government & Policy Concentrates p. 26 (Member Content)
- EPA Seeks Tougher SO₂ Rule
- EPA proposed new air quality regulations last week for sulfur dioxide emissions, which come primarily from coal-burning...
- Senate Panel Okays Food Safety Bill
- The Senate Health, Education, Labor & Pensions Committee unanimously approved a food safety bill on Nov. 18...
- Refinery Accidents Under Investigation
- Recent refinery accidents in Puerto Rico and Utah are under investigation...
- Radiation Detector Still Underperforming
- A congressional hearing last week sought new information about the Department of Homeland Security's...
- Unions, Communities Urge End Of HF Use
- The United Steelworkers and several Texas community groups have announced a national campaign to pressure refineries to stop...
» more government & policy news...
ACS Comment
Chemistry Ambassadors: Minding The Gap And Filling It p. 37 (Member Content)
Science & Technology
Hot Flashes: Still A Mystery pp. 33-35 (Member Content)
Researchers develop new treatments without fully understanding this common symptom of menopause.
Inside Instrumentation p. 36 (Member Content)
Technology and Business news for the laboratory world.
Science & Technology Concentrates pp. 31-32 (Member Content)
- Prion Aggregator Discovered
- A glycosylated protein may shepherd prion protein associated with brain disorders into its infectious form
- Splashdown On The Moon Kicks Up Water
- Data from the LCROSS mission lets NASA researchers confirm that there’s water on the moon
- Black-Market Androgen
- Andarine, a selective androgen receptor modulator, is the latest in a line of drugs abused by elite athletes
- Nitrogen-Fixing For Insects
- It’s not just plants and termites that rely on symbiotic nitrogen-fixing bacteria––ants do too
- Potential Down Syndrome Therapy Works In Mice
- A norepinephrine precursor helps reverse learning and memory difficulties in lab studies
- Detergent Dependably Busts Up Aggregates In Drug Screens
- Evidence that drugmakers can’t predict false positive hits reemphasizes the helpfulness of detergents
- Modulating MOFs
- A postsynthetic modification provides control over the flexible “breathing” behavior of pores in metal-organic frameworks
- Seeing Disulfides Via Diselenide Proxies
- Replacing cysteine with selenocysteine in proteins improves NMR observation of disulfide bridges
» more science & technology news...
Editor's Page
Inherently Safer p. 3
The Departments
Letters pp. 4-5
Newscripts p. 56
The Science And Smells Of Thanksgiving
This Week Online
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