Custom Chemicals
Quote of the Week
"I personally don't think it will be very easy for us to bring the carbon cycle back into balance during the next few decades, unless we look at carbon sequestration."
PAUL ALIVISATOS, DIRECTOR, LAWRENCE BERKELEY NATIONAL LABORATORY – p. 55
February 8, 2010
In This Issue:
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Highlights
Cover Story
Custom Chemicals
After struggling through 2009, contract manufacturers are honing their strategies and hoping for a better 2010. (pp. 15-20)
» Taking Over Big Pharma Plants
Business
Antibiotics Yo-Yo (Member Content)
Companies score big deals but still struggle with regulatory authorities. (pp. 30-33)
Science & Technology
Back To The Future With Stem Cells
Reprogramming the fate of cells with small molecules. (pp. 50-53)
Table of Contents
Cover Story
Custom Chemicals pp. 15-20
After struggling through 2009, contract manufacturers are honing their strategies and hoping for a better 2010.
Taking Over Big Pharma Plants pp. 21-26
For better or worse, pharma chemical suppliers are repurposing former drug company plants as custom manufacturing facilities.
News Of The Week
Science Wins In 2011 Budget p. 9
Federal Spending: Nondefense R&D jumps 6% in president’s request even as overall R&D remains flat.
Amantadine's Double Bind p. 10
Mode of Action: New finding on flu drug's binding to virus proton channel could aid drug design.
Gates Supports Vaccines Again p. 10
Funding: Major grant will advance vaccine research and distribution in poor countries.
More R&D Cuts From Big Pharma p. 11
Employment: GSK, AstraZeneca, Pfizer slash research jobs, spending.
Reaction-Driven Mixing p. 11
Fluid Dynamics: Chemical interactions drive convection and stirring.
Latin American Firms Globalize p. 12
Outward Reach: Mexican and Brazilian chemical companies acquire internationally.
Promising To Control Emissions p. 12
Climate Change: U.S., China, others pledge to limit greenhouse gases.
Lax About Nanomaterial Handling p. 13
Exposure: Many protective measures are not being utilized, survey shows.
Progesterone Proof p. 13
Natural Products: New evidence confirms suspicion that plants can also make well-known hormone.
Business
Antibiotics Yo-Yo pp. 30-33 (Member Content)
Companies score big deals but still struggle with regulatory authorities.
Resurrection On The Rhine pp. 34-36 (Member Content)
A downsized Rohner gets another crack at contract manufacturing.
Sustaining Clean pp. 38-39 (Member Content)
At SDA meeting, companies big and small sought to collaborate on sustainability.
Business Concentrates pp. 28-29 (Member Content)
- Dow Posts Quarterly Profit
- Sales increases and cost-cutting measures have carried Dow Chemical to fourth-quarter profits of $295 million...
- Rhodia And Invista Tangle Again
- A Paris arbitration panel has sided with Rhodia in a dispute with Invista over the rights to technology...
- Lanxess To Build Formaldehyde Plant
- Lanxess will build a $25 million formaldehyde plant at its site in Krefeld-Uerdingen, Germany...
- LS9, ZeaChem Move Beyond Lab Scale
- Synthetic biology firm LS9 has purchased a fermentation facility in Okeechobee, Fla....
- Cellulosic Ethanol Facility Opens
- Genera Energy has opened a 250,000-gal-per-year cellulosic ethanol plant in Vonore, Tenn....
- Dow Advances Plan For Solar Shingles
- Dow Chemical has picked Midland, Mich., as its preferred site for a full-scale plant to make its Powerhouse solar shingles...
- Thermo Acquires Finnzymes, NovaWave
- Thermo Fisher Scientific has agreed to buy Finnzymes...
- Lanxess Enhances Golf Ball’s Range
- The first commercial application for Lanxess’ new Buna CB21 neodymium polybutadiene rubber is the Kira Star golf ball...
- Peakdale To Work At A Pfizer Site
- Peakdale Molecular, a U.K.-based contract research firm, will provide custom chemistry services to Pfizer at the drug company’s Sandwich, England, site. ...
- AB Sciex Debuts As A New Company
- AB Sciex has been launched as a single operating company dedicated to analytical instruments for the life sciences...
- Cephalon Will Buy Generics Firm Mepha
- In a bid to diversify its product offerings, Cephalon will pay roughly $590 million for the Swiss generic drug firm Mepha...
- Galapagos Acquires Service Firm Argenta
- Galapagos, a Belgian biotech firm, has acquired Argenta Discovery’s Services Division for about $23 million...
- Roche And Singapore Set Up R&D Center
- Roche and a coalition of agencies associated with the Singapore government will spend $95 million to set up a research center...
- Business Roundup
- Oxford Catalysts, DuPont, Dow Venture Capital, AkzoNobel, GlaxoSmithKline, Poniard Pharmaceuticals, Spectrum Pharmaceuticals, Abbott Laboratories...
Awards
2010 ACS National Award Winners pp. 60-63 (Member Content)
Frederic Stanley Kipping Award In Silicon Chemistry p. 60 (Member Content)
ACS Award In Colloid & Surface Chemistry pp. 60-61 (Member Content)
ACS Award For Creative Work In Fluorine Chemistry p. 61 (Member Content)
ACS Award For Encouraging Disadvantaged Students Into Careers In The Chemical Sciences p. 62 (Member Content)
ACS Award In Theoretical Chemistry pp. 62-63 (Member Content)
Peter Debye Award In Physical Chemistry p. 63 (Member Content)
Government & Policy
Public-Access Options Mulled pp. 41-43 (Member Content)
Forum yields comments on making articles containing federally funded research results freely available.
Asia's Growing Impact On Research pp. 44-46 (Member Content)
Latest "Science & Engineering Indicators" shows R&D global trends shifting east.
Government & Policy Concentrates p. 40 (Member Content)
- EPA Gives Boost To Corn-Based Ethanol
- EPA Administrator Lisa P. Jackson has announced a determination by the agency that corn-based ethanol qualifies as a renewable energy...
- Tax Hikes Could Hurt Export Drive
- In his State of the Union address, President Barack Obama set an ambitious goal of doubling U.S. exports within five years...
- DOD Names New Faculty Fellows
- The Department of Defense has tapped 11 university faculty scientists to receive awards as part of its...
- Radioactive Waste Commission Selected
- Nuclear Energy: Blue Ribbon panel given 18-months to set fate of radioactive waste...
- Methane Hydrate Program Assessed
- The Department of Energy's research program on extracting methane from methane hydrates to augment U.S. energy supplies...
» more government & policy news...
Employment
Skills For Success pp. 67-69
Pharma firms are seeking adaptable scientists with the aptitudes to meet new business needs.
This Week Online
Reel Science
A father goes through "Extraordinary Measures" to save his kids from a rare disease.
» read more...
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
Back To The Future With Stem Cells pp. 50-53
Reprogramming the fate of cells with small molecules.
Choosing One Among Many p. 54 (Member Content)
Chemists get better at oxidizing specific C–H bonds.
C&EN Talks WIth Paul Alivisatos p. 55 (Member Content)
LBNL's new director focuses on renewable energy, climate.
Science & Technology Concentrates pp. 48-49 (Member Content)
- Mosquito Olfaction
- Studying how mosquito odorant receptors respond to “human volatiles” could improve control of the disease-transmitting insects
- Tree Bark Inspires Vaccine Adjuvants
- Synthetic saponin analogs have potential to improve immune response to vaccines and thus improve vaccine efficacy
- New Kinase Matchmaker
- Photoactivated ATP analog is the first phosphorylation-dependent tool for mediating kinase-substrate cross-linking
- A Methyl Group Makes Us Complex
- Histone methylation recruits mRNA splicing machinery, helping explain how humans are so complex with relatively few genes
- Study Strengthens Alzheimer’s Link To Cholesterol
- Findings on the mechanism of a cholesterol metabolism pathway could aid development of new therapeutics
- Versatile Ketene Polymers
- Seldom-used ketene group is a useful addition to the growing list of functionalization strategies for polymer chemistry
- Chiral Sulfide Boosts Ylide Chemistry
- Inexpensive isothiocineole demonstrates high selectivity in asymmetric syntheses of epoxides and aziridines
- Exoplanet’s Methane Spotted From Hawaii
- A Mauna Kea infrared telescope detects gases in the atmosphere of a distant planet––a first from Earth’s surface
» more science & technology news...
Education
Lights, Camera, Chemistry pp. 56-58
Learning how to make lab demonstration videos can pay off for instructors and students.
Showing Your Good Side Web Exclusive
Simple tips can make filming lab demos go smoothly.
Student-Sourced Teaching Web Exclusive
Instructional multimedia can tap the wisdom of the masses.
Meetings
2010 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community is for January through December.
The Departments
Letters pp. 3-7
Newscripts p. 72
Vile Weed Or Essential Ingredient?
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