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Pharmaceutical Business
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Quote of the Week

"In an industry where innovation lies at the core, cutting R&D should raise at least some red flags."
TIM ANDERSON, ANALYST, BERNSTEIN RESEARCHp. 24

February 22, 2010

In This Issue:

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October 24, 2011 Issue
October 17, 2011 Issue
October 10, 2011 Issue
October 3, 2011 Issue

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Highlights

Cover Story

Cracking The Tough Ones

Drug firms hope to accelerate their quest for evasive cures through partnerships. (pp. 12-18)

Science & Technology

Making Use Of Neutrons

Subatomic particles provide new ways to study structure, dynamics of materials. (pp. 36-39)

Education

Professors Cry Foul Over Website

Questions about copyright infringement nag at academic social-networking site Course Hero. (p. 41)

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Table of Contents

News Of The Week

Activation Of Protein Tags Obama Sings A Nuclear Tune Expanding The Genetic Code Yara Buys Terra

Activation Of Protein Tags p. 7

Enzymology: To prepare biological labels for attachment, E1 enzymes dramatically remodel themselves.

Partnerships Debut At Informex p. 8

Fine Chemicals: Trade show finds suppliers vying for position on high-tech outsourcing.

Obama Sings A Nuclear Tune p. 8

Renaissance: administration offers $8.3 billion in loan guarantees for nuclear power plants.

Expanding The Genetic Code p. 9

Molecular Biology: New ribosome can install multiple unnatural amino acids in a protein.

National Academy Of Engineering p. 9

New members include 18 people with chemistry connections.

Yara Buys Terra p. 10

Mergers: International consolidation in fertilizer business picks up.

A New Facet Of Drug Resistance p. 10

Antibiotics: Low doses of one medication can cause resistance to that one and others.

Cellular Joy Stick p. 11

Biochemistry: Acetylation controls much more biology than previously expected.

China's Environment p. 11

Unsustainable agricultural practices attract attention.

Business

Sales And Earnings Turn Positive pp. 21-23 (Member Content)

Fourth-quarter results suggest a slow recovery is taking hold for the chemical industry.

Transforming Pharma pp. 24-26 (Member Content)

Despite healthy year-end results, drug firms are shaking up R&D in anticipation of tough times ahead.

Business Concentrates pp. 19-20 (Member Content)

  • LyondellBasell Clears Bankruptcy Hurdle
  • LyondellBasell Industries has cleared a major obstacle to its bankruptcy reorganization...
  • AMRI acquires U.K.’s Excelsyn
  • Contract research organization AMRI has acquired Excelsyn, a U.K. pharmaceutical chemical manufacturer, for about $19 million in cash...
  • Bayer Showcases Conductive Inks
  • Bayer has introduced two aqueous conductive ink formulations for printed electronics...
  • Air Products Pressures Airgas
  • As part of its $60-per-share hostile takeover bid for Airgas, Air Products & Chemicals has charged that Airgas founder and CEO Peter McCausland has engaged in insider trading...
  • Clariant Details Job Cuts
  • Switzerland-based Clariant has provided details on the 500 job cuts CEO Hariolf Kottmann revealed recently at a meeting of investors...
  • AB Sciex Buys Instrument Business
  • In its first acquisition since being purchased late last year by industrial and medical toolmaker Danaher...
  • Arch Divests Industrial Coatings
  • Arch Chemicals has signed a definitive agreement to sell its industrial coatings business to paint maker Sherwin-Williams for $40 million...
  • Nova To Tap Into Marcellus Shale
  • Nova Chemicals and the pipeline firm Buckeye Partners plan to evaluate a pipeline to transport natural gas liquids from the Marcellus basin...
  • Vale Buys Majority Stake In Fosfertil
  • Brazilian mining firm Vale plans to spend more than $5 billion to buy nearly 80% of Fosfertil...
  • Novozymes To Sell Cheaper Enzyme
  • At last week’s U.S. National Ethanol Conference, Danish enzyme producer Novozymes unveiled an enzyme that will make it possible...
  • Corn For Sub-Saharan Africa
  • The Bill & Melinda Gates Foundation will provide $19.5 million for the Improved Maize for African Soils collaboration to create new corn varieties...
  • AstraZeneca, Rigel Sign Drug Pact
  • AstraZeneca will pay $100 million up front for access to Rigel Pharmaceuticals’ fostamatinib,...
  • SLU Hires Former Pfizer Scientists
  • St. Louis University (SLU) is soaking up some of the 600 local Pfizer scientists laid off in the pharma company’s latest round of cutbacks...
  • Business Roundup
  • Honam Petrochemica, Air Liquide, Carbon Holdings, Linde Nippon Sanso, Kuraray, International Flavors & Fragrances, PotashCorp of Saskatchewan, Abbott Laboratories has acquired Solvay Laboratories...

Awards

2010 ACS National Award Winners pp. 43-49 (Member Content)

Government & Policy

Fighting Bioterrorism pp. 29-31 (Member Content)

White House vows action after panel says U.S. remains unprepared for biological attack.

Seeking Funds For Geoengineering pp. 32-33 (Member Content)

Scientists tell House subcommittee that the U.S. needs an additional federal climate research program.

Government & Policy Concentrates p. 28 (Member Content)

  • Senate Jobs Bill Drops R&D Credit
  • Senate Majority Leader Harry M. Reid’s (D-Nev.) decision to proceed with a scaled-down jobs bill leaves the lapsed tax credit for R&D spending in limbo...
  • Three Companies Quit Climate Group
  • BP, Caterpillar, and ConocoPhillips have dropped their membership in the U.S. Climate Action Partnership...
  • California Considers BPA For Toxics List
  • California regulators are considering adding the plastics chemical bisphenol A (BPA) to Proposition 65—the state’s list of chemicals known to cause cancer, birth defects...
  • Railroad Rate Hikes Warranted By Costs
  • An independent study commissioned by the federal Surface Transportation Board (STB) has found that freight railroad rates have been steadily increasing since 2004...
  • Report Assesses Stimulus Spending
  • More than half of the $787 billion appropriated by the American Recovery & Reinvestment Act of 2009 has been obligated or spent...

ACS Scholars

Chavonda J. Mills p. 42

Mentoring changed this ACS Scholar's life, now she hopes to pass her experiences on.

This Week Online

Reel Science

A father goes through "Extraordinary Measures" to save his kids from a rare disease.
» read more...

Facebook

Social Networking And C&EN

Social Networking And C&EN

You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.

Science & Technology

Making Use Of Neutrons pp. 36-39

Subatomic particles provide new ways to study structure, dynamics of materials.

Spiders Seeking Sex p. 40

Arachnid courtship pheromones point to a new class of natural products.

Science & Technology Concentrates pp. 34-35 (Member Content)

Education

Professors Cry Foul Over Website

Professors Cry Foul Over Website p. 41

Questions about copyright infringement nag at academic social-networking site Course Hero.

Meetings

2010 C&EN Calendar Web Exclusive

C&EN's latest list of meetings and events of interest to those in the chemical community is for February through December.

Editor's Page

California Dreaming p. 3

People

Obituaries pp. 50-51 (Member Content)

The Departments

Letters pp. 4-5

Newscripts p. 56

Wax On, Wax Off

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