Pharmaceuticals
Quote of the Week
"Chemistry is not about someone wearing big goggles and a lab coat and bubbling solutions in a basement somewhere; it is not isolating at all."
BART M. BARTLETT, PROFESSOR, UNIVERSITY OF MICHIGAN, ANN ARBOR – p. 69
September 27, 2010
In This Issue:
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Highlights
Cover Story
Guidelines On Genotoxicity
Regulators' conservative limits have drugmakers clambering to avoid or reduce DNA-reactive impurities. (pp. 16-26, 27-29)
Business
New Management(Member Content)
Private equity firms are investing in the risky business of fine and pharmaceutical chemical manufacturing. (pp. 32-34)
Education
The Future Of Textbooks
ACS Meeting News: Technology provides more options, but print textbooks will remain, at least for now. (pp. 63-64)
Table of Contents
Cover Stories
Genotoxic Impurities pp. 16-26
Faced with new guidelines that many find constraining, pharmaceutical manufacturers are seeking ways to avoid or reduce harmful contaminants in drugs.
Detecting Low-Level Impurities pp. 27-29
Controlling genotoxic impurities means finding the analytical method best suited to the task.
News Of The Week
Probing the Key Vision Event p. 11
Ultrafast Spectroscopy: Rhodopsin isomerization owes speed to conical intersection between electronic states.
Johnson & Johnson Negotiating To Buy Crucell p. 12
Biopharmaceuticals: Acquisition poised to create vaccine franchise for drug conglomerate.
Science Education Found Wanting p. 12
Federal Programs: Presidential advisers seek improved coordination for science and math education.
Light Controls Surface-Charging p. 13
Electrostatics: Method could reveal mechanism of ubiquitous phenomenon behind static cling, copy machines.
More Linda Buck Retractions p. 13
Nobelist retracts two more studies on olfaction that could not be reproduced.
Walmart Turns To Thin-Film Solar p. 14
Renewable Energy: Project will give Miasolé and First Solar a rooftop tryout.
Oil Spill's Size Swells p. 14
Deepwater Horizon: Magnitude of Gulf accident is far larger than previous estimates.
Assay For Key Ghrelin Enzyme p. 15
Click Chemistry: Approach could help researchers find antiobesity drug leads.
White House Calls On Francisco p. 15
ACS president will join Administration's committee on the National Medal of Science.
Business
New Management pp. 32-34 (Member Content)
Private equity firms are investing in the risky business of fine and pharmaceutical chemical manufacturing.
JAK Hammers pp. 36-39 (Member Content)
ACS Meeting News: JAK2 inhibitors show promise at knocking down the symptoms of rare blood cancers.
Catalyst For Sustainability p. 40 (Member Content)
Green chemistry is touted as a model of industrial and pharmaceutical process efficiency.
Business Concentrates pp. 30-31 (Member Content)
- U.S. Contracts Aim To Boost Medical Emergency Readiness
- As part of a plan to bolster terrorism defenses, the Department of Health & Human Services’ Biomedical Advanced Research & Development Authority (BARDA) has awarded a contract to Emergent BioSolutions for the development of a recombinant protective antigen anthrax vaccine...
- Abbott To Cut Jobs After Solvay Deal
- Abbott Laboratories has announced a restructuring plan aimed at integrating Solvay’s pharmaceuticals business...
- Omnova To Buy Eliokem From AXA
- Omnova Solutions has signed an agreement with AXA Private Equity to acquire French specialty chemical maker Eliokem for $300 million...
- Evonik Will Sell Carbon Black Business
- Following the July spin-off of its carbon black business as an independent unit, Evonik Industries has decided to divest the business outright....
- Organic Photovoltaics Firm Launched In England
- Eight19, a new solar energy company based on chemistry developed in the University of Cambridge’s Cavendish Laboratory, has been launched...
- Bayer Develops Solar Heat Collector
- Bayer MaterialScience has teamed up with insulating foam manufacturer Puren to develop a solar heat collector. Mounted on a building roof...
- Dow Advances Wind Energy Materials
- Dow Chemical has signed an agreement with two partners to develop better windmill components...
- DSM Sells Rubber Business To Teknor
- DSM is selling its Sarlink business to plastic compounder Teknor Apex for an undisclosed sum...
- Trius And Scripps Win Defense Contract
- Trius Therapeutics and Scripps Institution of Oceanography will work together to develop novel antibiotics against pathogens that could be used as bioweapons...
- Eastman Expands 2-Ethylhexanol
- Eastman Chemical is planning to expand capacity for 2-ethylhexanol at its Longview, Texas, plant by 37,000 metric tons per year...
- BASF, Solix Join For Chemicals From Algae
- BASF and Solix Biofuels have signed an agreement to investigate the use of algae to produce chemicals for BASF...
- DSM Buys Microbia For Carotenoids
- DSM has acquired Microbia from Ironwood Pharmaceuticals for an undisclosed sum...
- Novartis Shutters Antibiotic Firm Protez
- Just two years after acquiring Protez Pharmaceuticals, Novartis has shuttered the biotech firm and stopped developing its broad-spectrum antibiotic candidate, PTZ601...
- Business Roundup
- Iogen, Sumitomo, Dow AgroSciences, Evonik Industries, La Seda, Wacker Chemie, Aquapharm Discovery, Mitsui & Co., Johnson & Johnson...
Education
The Future Of Textbooks pp. 63-64
ACS Meeting News: Technology provides more options, but print textbooks will remain, at least for now.
Books
Of Food, Drugs, And Brain Chemistry pp. 65-66
A look at how the substances we ingest can affect our brains and behavior.
ACS News
ACS Goes Virtual pp. 70-71
Network, interview, and attend workshops online at the ACS Virtual Career Fair.
Employment
Leaping To New Opportunities pp. 75-78
In an unfavorable pharma job market, many chemists are migrating to new careers.
Government & Policy
Children's Study Faces Tough Year pp. 43-45 (Member Content)
New leadership will examine environmental methods, test alternative recruitment strategies.
NSF Revamps Data-Sharing Policy pp. 46-47 (Member Content)
Mandatory grant application supplements detailing how data will be shared will increase transparency, agency hopes.
Government & Policy Concentrates p. 42 (Member Content)
- EPA Studies Toxic Air Release From BP Refinery
- EPA has begun an investigation of a 40-plus-day release of hazardous air pollutants by BP at its Texas City, Texas, oil refinery...
- GAO To Review FBI’s Anthrax Probe
- The Government Accountability Office, the investigative arm of Congress, says it will review the scientific methods the FBI used when it concluded that Army scientist Bruce E. Ivins ...
- FDA Weighs Approval Of Engineered Salmon
- Genetically engineered salmon that grow about twice as fast as conventional salmon appear to be safe for human consumption, but there are gaps...
- OECD Sees Threats To U.S. Economic Recovery
- The Organization for Economic Cooperation & Development reports that the U.S. economy is slowly recovering from its severe recession but that the pace of economic growth is expected to remain slow for some time...
- Army Scales Back Chemical Weapons Plan
- The Defense Department has withdrawn a proposal to use explosive charges or heat to destroy 125,000 chemical weapons stored at the Army’s Pueblo Chemical Depot in Colorado...
» more government & policy news...
Awards
Alivisatos Wins Pauling Award p. 72 (Member Content)
Samuel Lord Is Irving Sigal Fellow p. 72 (Member Content)
Doug Turner Named Hammes Lecturer p. 72 (Member Content)
Daniel Chiu Wins Young Innovator Award p. 72 (Member Content)
Ismar Prize To Robert Griffin p. 72 (Member Content)
David Evans Wins Creativity Award p. 72 (Member Content)
CORESTA Prize to Rodgman and Perfetti p. 72-73 (Member Content)
Barry Karger Awarded Herovsky Medal p. 73 (Member Content)
Ayusman Sen Awarded CRSI Medal p. 73 (Member Content)
Robert Becker Is Missouri Teacher Of The Year p. 73 (Member Content)
Nominations Sought for Henry Hill Award p. 73 (Member Content)
Call For Nominations For Physical Chemistry Awards p. 73 (Member Content)
Call For Nominations For Herty Award p. 73 (Member Content)
Nominations Open For Remsen Award p. 73 (Member Content)
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
Putting DNA In A Bind pp. 50-53 (Member Content)
ACS Meeting News: Small molecules that interact with DNA are bound to regulate gene expression.
How Foods And Drugs Collide pp. 55-57 (Member Content)
ACS Meeting News: Interactions between medications, foods, and supplements take many forms.
Tenofovir For The Developing World pp. 58-59 (Member Content)
ACS Meeting News: Process chemists rework synthesis of anti-HIV drug to lower its cost.
Industry In The Ivory Tower pp. 60-61 (Member Content)
Ronald Breslow, a lifelong academic, garners the chemical industry's big prize, the Perkin Medal.
Science & Technology Concentrates pp. 48-50 (Member Content)
- Alkali Metal Aids Catalysis
- The water-gas shift reaction can be catalyzed at lower cost by platinum aided by an alkali-metal promoter
- Silver Nanoparticles Transform In Sewers
- Silver in our cosmetics and clothes can end up as silver sulfide nanoparticles in sewer sludge
- Unnatural Amino Acid Spurs Polymer Growth
- A synthetic amino acid containing a polymerization initiator promotes formation of protein-polymer bioconjugates
- Toxicity Risk Reduced For Isothiazole Drug
- Scientists take advantage of toxicity data to modify an anticancer drug to avoid the toxicity without altering efficacy
- Gut Gas Gives Salmonella A Boost
- The pathogenic bacterium gets energy from tetrathionate produced from gut inflammation that the bacterium causes
- Shorter Route To Strychnine Unveiled
- A surprising SmI2-mediated cascade reaction is at the heart of the shortest route to the poisonous natural product
- X-Ray Imaging Method Boosts Contrast Of Biological Features
- High-resolution 3-D technique resolves nanometer-sized structures with unprecedented clarity
- Low-Cost Phosphite Ligands Improve Metathesis Catalysts
- Phosphite ligands offer advantages over current catalysts for some challenging reactions
» more science & technology news...
ACS Scholars
Bart M. Bartlett p. 69
A laboratory enthusiast from a young age, this ACS Scholar is living his professional dream.
ACS Meetings
2010–11 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
Editor's Page
The Kavli Prizes p. 3
The Departments
Letters pp. 6-9
Newscripts p. 88
Poop-Powered Light, Crayons For Tiny Chemists, Beer's Proteome
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