Tight Spaces
Quote of the Week
"We may just press the pause button here for several years. But China is pressing the fast-forward button."
Rep. Robert D. Inglis Sr. (R-S.C.) – p. 30
November 29, 2010
In This Issue:
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Highlights
Cover Story
Close Quarters
Crowded conditions such as those in cells can affect proteins' structure, function, and activity. (pp. 9-13)
Business
Last-Minute Push For REACH Rule (Member Content)
Europe's Chemical Industry approaches first registration deadline and readies for more. (pp. 15-17)
Government & Policy
Untangling Biosimilars (Member Content)
FDA faces conflicting views on how to develop drug approval pathway. (pp. 25-27)
Table of Contents
News Of The Week
Yeast Ribosome Structure Solved p. 5
Crystallography: Details of translation machinery could help elucidate mechanism, regulation.
Merck Advances Cholesterol Drugs p. 6
Clinical Trials: Postive new data for both Vytorin and anacetrapib.
Low-Octane Climate Talks p. 6
Negotiations: Meeting in Mexico expected to produce only modest agreements.
Burning Question p. 7
Gulf Spill: EPA reports that surface slick burns produced very low levels of cancer-causing dioxins.
Blast At Chinese Plant Kills Four p. 7
Coal Chemicals: Facility made polyvinyl chloride via the acetylene process.
Roche Decision Reverbates p. 8
Pharmaceuticals: Drug firm's exit from RNAi space hits Alnylam, Tekmira.
In Search Of Cysteines p. 8
Chemical Biology: New technique finds superreactive cysteines in proteins.
Business
Last-Minute Push For REACH Rule pp. 15-17 (Member Content)
Europe's Chemical Industry approaches first registration deadline and readies for more.
Communication: Do You Speak My Language? p. 17 (Member Content)
Unlikely Matchmaker For Young Biotechs pp. 18-20 (Member Content)
NCI's small-business program moves beyond its typical grants to help companies find partners.
The Ups And Downs Of A One-stop Shop pp. 21-23 (Member Content)
AMRI hopes to rebound following setbacks in its Pharma Services Expansion in 2010.
Business Concentrates p. 14 (Member Content)
- China Piles Into Solar
- Solar-cell and finished module manufacturing capacity expansion in 2010 will be led by China, according to market research firm iSuppli...
- K+S Buying Potash One
- After BHP Billiton’s failure to purchase Canada’s PotashCorp, German fertilizer and salt maker K+S has reached an agreement to buy another Canadian potash firm...
- Siemens Claims CO2 Reduction Advance
- Siemens Energy claims that its CO2 reduction technology has achieved a CO2 capture efficiency of more than 90% in a pilot facility at a power plant owned by the firm E.ON...
- DuPont Settles Environmental Suit
- DuPont has reached a proposed settlement with class-action lawsuit members who claim pollution from a zinc smelter compromised their health....
- Mitsui Boosts Diaper Material
- Mitsui Chemicals will spend $60 million to boost output of spun-bonded nonwoven fabrics at a plant in Japan...
- ChemChina Reworking Deal For Makhteshim
- Terms of China National Chemical’s plan to acquire Israeli off-patent agricultural chemicals maker Makhteshim Agan Industries are being renegotiated...
- Gates Backs Work On Insecticides
- The Bill & Melinda Gates Foundation has awarded $50 million to the Innovative Vector Control Consortium to continue developing new insecticides to control insects that transmit malaria, dengue, and other neglected tropical diseases...
- Aurelius Acquires KemFine’s U.K. Unit
- The German private equity firm Aurelius has acquired KemFine UK from Finland’s KemFine Group...
Books
A Look At Ionic Liquids pp. 38-39
Introducing a field of chemistry that is constantly evolving.
ACS News
Andrew Washington Jr. p. 43
ACS Scholar hopes his success will inspire others
ACS Reaches Out Globally pp. 44-45
Society President Joseph S. Francisco furthers international collaborations in 2010
Kavli Lecturers Chosen For 2011 ACS National Meetings p. 46 (Member Content)
People
Government & Policy
Untangling Biosimilars pp. 25-27 (Member Content)
FDA faces conflicting views on how to develop drug approval pathway.
Political Climate Changes pp. 30-31 (Member Content)
Republicans' stance on global-warming science suggests a rough road ahead for researchers.
Government & Policy Concentrates p. 24 (Member Content)
- EPA Expands Endocrine Disruptor screening Program
- EPA plans to add drinking-water contaminants and more pesticides to the list of chemicals to be tested under its Endocrine Disruptor Screening Program...
- Joint Research Is More Expensive
- Earth and space science research conducted by federal agency collaboration typically results in additional complexity, cost, and risk...
- Paper Details Effort To Control Oil Spill
- A draft staff report from the government commission investigating the effort to cap the BP oil spill in the Gulf of Mexico this year provides details and insights on the process...
- Philadelphia Limits Cleaning Solvents
- Philadelphia is halting the use of two popular solvents—perchloroethylene and n-propyl bromide—at many dry cleaners...
- EPA Rules Address CO2 Sequestration
- Carbon dioxide sequestration is the focus of two rules EPA issued last week...
» more government & policy news...
ACS Comment
Get Involved: Send A Letter, Create A Committee, Or Run For Elective Office p. 41 (Member Content)
Awards
Shinya Yamanaka Wins Kyoto Prize p. 46 (Member Content)
Negishi And Suzuki Awarded Japan's Order Of Culture pp. 46-47 (Member Content)
Helen Free Award To William Deese p. 47 (Member Content)
George Whitesides Is Cotton Medalist p. 47 (Member Content)
Spencer Award Call For Nominations p. 47 (Member Content)
Terry Acree Wins AGFD Award p. 46 (Member Content)
Midwest Award To John Verkade p. 46 (Member Content)
Harrison Howe Award To Joseph DeSimone p. 46 (Member Content)
Nominations Sought For Skolnik Award p. 46 (Member Content)
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
Online Outreach pp. 34-35 (Member Content)
Chemists are taking to web tools to fulfill 'broader impact' requirement in NSF grants.
Mismatch Route To Targeted Therapy p. 36 (Member Content)
RNA with less than perfect complementarity blocks expression of Huntington's Disease gene sequence.
Imaging Molecules On Living Cells p. 37 (Member Content)
Click-chemistry technique provides a nontoxic way to visualize biomolecules on cell surfaces in vivo.
Science & Technology Concentrates p. 33 (Member Content)
- Hollow Graphene Spheres
- Layer-by-layer deposition over a polystyrene bead template leads to a new type of graphene structure
- Building Boggsite
- Phosphazenes help guide the formation of pores and channels for synthesizing the rare zeolite mineral
- Popcorn Lung Triggers Laid Bare
- Scientists present the first structural glimpse of diacetyl-arginine adducts, which could help determine diacetyl toxicity
- Imaging Pinpoints Nanoparticle Atoms
- Combining TEM and computer simulations provides an intimate analysis of bimetallic cluster catalysts
- Hartley 2 Reveals More Surprises
- The comet’s tail is composed largely of CO2, but its nucleus is surrounded by “dandelion puffs” of water ice
» more science & technology news...
ACS Meetings
2010–11 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
Editor's Page
Disturbing Trends p. 3
The Departments
Letters pp. 2, 4
Newscripts p. 56
Food Science, Fly Repellant, Perfume App
C&EN Archives
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Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS In Research
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
» News, notes, and musings from C&EN
Check out some of the recent posts from C&EN's blog, "C&ENtral Science"
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