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Quote of the Week

"A lot of people are in favor of innovative funding models—as long as you continue to fund their research."
ALAN GUTTMACHER, DIRECTOR, NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTp. 29

January 24, 2011

In This Issue:

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October 24, 2011 Issue
October 17, 2011 Issue
October 10, 2011 Issue
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Highlights

Cover Story

Phosphate-Free Formulas

New laws prompt makers of automatic dishwasher detergents to frantically seek effective replacements for phosphates. (pp. 12-17)

» Ecover Succeeds Without Phosphates—Or Petrochemicals
Government & Policy

Transforming Deep-Sea Drilling (Member Content)

BP spill commission calls for sweeping changes in industry practices, federal regulation. (pp. 24-26)

Science & Technology

Shotgun Approach To Drugs (Member Content)

Pacifichem News: Polypharmacology gives rise to drugs with multiple targets. (pp. 32-33)

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Table of Contents

News Of The Week

Bayer Accused Of Skirting Safety p. 7

Investigation: Rush to production caused plant explosion in West Virginia, safety board concludes.

Big Pharma Goes Back To School p. 8

Partnerships: Sanofi, Johnson & Johnson are latest firms to ink research pacts.

Tagging Cholesterol p. 8

Chemical Biology: Click chemistry helps label cholesterylated proteins.

Enzymatic Revelation p. 9

Structural Biology: Structure provides insight into sugar-transferring enzyme.

GlaxoSmithKline Take A Big Hit p. 9

Firm announces $3.5 billion charge to cover lawsuits, investigation of marketing practices.

Praise For Obama's Rules Review p. 10

Federal Policy: Industry endorses President's directive on federal regulations.

Giving DNA A Good Yank p. 10

Biophysics: Find adds fodder to question about nature of overextended DNA.

Surprising Superoxide p. 11

Catalysis: Novel mode of end-on oxygen binding discovered in palladium complexes.

African Chemists Meet In Johannesburg p. 11

International: Conference draws 500 people with themes of chemistry and Africa's future, sustainability.

Business

Using Pore Power pp. 20-21 (Member Content)

New zeolite technologies help refiners crack crude and trucks clean up emissions.

Stimulus Program Underwhelms p. 22 (Member Content)

Small pharma firms cite government's glaring underestimation of the response to a $1 billion program.

Business Concentrates pp. 18-19 (Member Content)

Career & Employment

Research Renaissance pp. 48-50

Despite challenges, scientist-educators flourish where arts and sciences mingle.

Awards

2011 ACS National Award Winners pp. 36-40 (Member Content)

Recipients are honored for contributions of major significance to chemistry.

Government & Policy

Transforming Deep-Sea Drilling pp. 24-26 (Member Content)

BP spill commission calls for sweeping changes in industry practices, federal regulation.

Industry Applauds Korean Trade Deal pp. 27-28 (Member Content)

Trade is as an area of potential collaboration between Obama and empowered Republicans.

Preaching Convergence p. 29 (Member Content)

Deeper integration of disciplines would benefit science, in particular biomedical research, MIT paper posits.

Government & Policy Concentrates p. 23 (Member Content)

People

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Social Networking And C&EN

Social Networking And C&EN

You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.

This Week Online

Science & Technology

Shotgun Approach To Drugs pp. 32-33 (Member Content)

Pacifichem News: Polypharmacology gives rise to drugs with multiple targets.

Science & Technology Concentrates pp. 30-31 (Member Content)

Education

Switching To Green pp. 34-35

UC Berkeley continuing education program helps professionals add green chemistry to their résumés.

Meetings

Fall 2011 ACS National Meeting pp. 41-45 (Member Content)

Divisions issue calls for papers for the Aug. 28–Sept. 1 meeting in Denver.

2011 C&EN Calendar Web Exclusive

C&EN's latest list of meetings and events of interest to those in the chemical community.

Editor's Page

A Program To Emulate p. 3

The Departments

Letters pp. 4-5

Newscripts p. 56

How Cats Lap, Periodic Table On A Hair (With Videos)

C&EN Archives

C&EN Archives

Now the history of the chemical enterprise is instantly accessible online. C&EN Archives holds the complete collection of C&EN issues dated back from 1923, covering world chemical events, breakthroughs in research, technological advances, business and marketing ventures, government policy, career and education trends, and ACS milestones. With more than 500,000 pages of content, C&EN Archives is instantly accessible and fully searchable, allowing you to discover how the chemical enterprise developed into what it is today.

Head here to discover the past via the C&EN Archives, go to http://pubs.acs.org/cen-archives

Environmental SCENE News

Fertilizer May Help Bacteria Slip Into Groundwater

Water Safety: High phosphate levels allow deadly microbes to pass through soil.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Sunlight Is An Effective Disinfectant

Public Health: Field work shows that a cheap water treatment method improves children's health.

House Takes Aim At Clean Air Act

Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.

Analytical SCENE News

New Method Isolates Membrane Proteins

Protein Purification: Technique separates proteins on a lipid bilayer.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Mapping Drugs In Human Tissue

Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.

Skeletons Come To Light

Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.

Analyzing Nuclear Processes

ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.

JACS Research In C&EN

Indole Changeup Yields Elusive Alkaloid

ACS Meeting News: Cyclization and nitrene insertion star in synthesis.

Prefab Synthesis Moves Ahead

Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.

Multiple Bradykinin States Revealed

The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.

Scaling Up The Axinellamines

A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.

A Revamped Vancomycin

Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.

CENtral Science

» News, notes, and musings from C&EN

Check out some of the recent posts from C&EN's blog, "C&ENtral Science"


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