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Transmembrane Proteins
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Quote of the Week

"Processes in nature have decades to evolve—we don't have that luxury. If you're lucky, you have a four-year grant."
R. DAVID HOLBROOK, CHEMICAL ENGINEER, NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGYp. 44

March 14, 2011

In This Issue:

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October 24, 2011 Issue
October 17, 2011 Issue
October 10, 2011 Issue
October 3, 2011 Issue

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Highlights

Cover Story

From Picture To Pill

Debut of G-protein-coupled receptors will bolster drugmakers' tool kits. (pp. 15-21)

» Meet The Structure Specialists
Science & Technology

Inflammation Stokes Cancer (Member Content)

When it goes awry, this defense mechanism can contribute to all stages of cancer progression. (pp. 40-43)

ACS News

Starting Salaries

Chemistry and chemical engineering graduates in 2009 faced a tough job market and falling median salaries. (pp. 49-53)

» To A Degree: Chemical engineering and chemistry grads
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Table of Contents

News Of The Week

House Panel Votes To Halt Climate Rules p. 9

Environment: Republicans push antiregulatory agenda.

China Outlines Path Forward p. 10

People's Congress: Business leaders see opportunity in country's next five-year plan.

Nanodiamonds Fight Cancer p. 10

Chemotherapy: Faceted nanomaterials deliver drugs to tumor cells.

Oil Spill's Air Effects Probed p. 11

Deepwater Horizon: Aircraft data show how accident's emissions affected Gulf of Mexico atmosphere.

Gates Foundation Backs Liquidia p. 11

Philanthropy makes its first biotech equity investment.

Senate Rejects House Budget Cuts p. 12

Congress: Legislators remain divided about how much to reduce fiscal 2011 spending.

Poised To React p. 12

Nanoscience: Tethering molecules to gold surface forces reaction.

First Hit For A Cancer Target p. 13

Drug Discovery: Academic collaboration leads to nanomolar inhibitor for phosphatase methylesterase-1.

Crop Protection p. 13

India's Jubilant to commercialize new route to key insecticide intermediate.

Business

Transformed DSM Targets Growth pp. 24-27 (Member Content)

After restructuring, CEO Feike Sijbesma has a four-pronged strategy for expansion.

Stem Cell Surge pp. 28-29 (Member Content)

Cellular Dynamics, a pioneer in induced pluripotent stem cells, is creating a new services sector.

Business Concentrates pp. 22-23 (Member Content)

ACS News

Starting Salaries pp. 49-53

Chemistry and chemical engineering graduates in 2009 faced a tough job market and falling median salaries.

To A Degree: A Brief comparison of chemical engineering and chemistry grads p. 52

Council Preview pp. 54-55

Election of candidates will be main order of business at ACS National meeting in Anaheim, Calif.

Dance For IYC In Anaheim p. 55

Nominations Open For ACS Fellows p. 55

This Week Online

Government & Policy

ARPA-E Confab Draws Unusual Supporters pp. 32-33 (Member Content)

Key Republican Party leaders back clean energy R&D program.

Biosensors On The Fast Track pp. 34-35

Regulators join forces with developers to speed up approval of transformative devices.

Strengthening Science Abroad p. 36 (Member Content)

U.S. federal agencies examine their role in capacity building in developing countries.

Government & Policy Concentrates p. 30 (Member Content)

Facebook

Social Networking And C&EN

Social Networking And C&EN

You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.

Science & Technology

Inflammation Stokes Cancer pp. 40-43 (Member Content)

When it goes awry, this defense mechanism can contribute to all stages of cancer progression.

Moving Up The Food Chain pp. 44-46 (Member Content)

As they transfer to higher organisms in a food web, nanomaterials can increase in concentration, new studies show.

Plastics Release Estrogenic Chemicals p. 48

Study finds that even BPA-free products leach potentially problematic compounds.

Science & Technology Concentrates pp. 38-39 (Member Content)

Meetings

42nd Middle Atlantic Regional Meeting pp. 56-57 (Member Content)

ACS Hosts Public Relations Workshop p. 57 (Member Content)

2011 C&EN Calendar Web Exclusive

C&EN's latest list of meetings and events of interest to those in the chemical community.

The Departments

Letters pp. 5-6

Newscripts p. 64

Commemorative Chemistry Stamps

C&EN Archives

C&EN Archives

Now the history of the chemical enterprise is instantly accessible online. C&EN Archives holds the complete collection of C&EN issues dated back from 1923, covering world chemical events, breakthroughs in research, technological advances, business and marketing ventures, government policy, career and education trends, and ACS milestones. With more than 500,000 pages of content, C&EN Archives is instantly accessible and fully searchable, allowing you to discover how the chemical enterprise developed into what it is today.

Head here to discover the past via the C&EN Archives, go to http://pubs.acs.org/cen-archives

Environmental SCENE News

Fertilizer May Help Bacteria Slip Into Groundwater

Water Safety: High phosphate levels allow deadly microbes to pass through soil.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Sunlight Is An Effective Disinfectant

Public Health: Field work shows that a cheap water treatment method improves children's health.

House Takes Aim At Clean Air Act

Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.

Analytical SCENE News

New Method Isolates Membrane Proteins

Protein Purification: Technique separates proteins on a lipid bilayer.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Mapping Drugs In Human Tissue

Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.

Skeletons Come To Light

Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.

Analyzing Nuclear Processes

ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.

JACS Research In C&EN

Indole Changeup Yields Elusive Alkaloid

ACS Meeting News: Cyclization and nitrene insertion star in synthesis.

Prefab Synthesis Moves Ahead

Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.

Multiple Bradykinin States Revealed

The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.

Scaling Up The Axinellamines

A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.

A Revamped Vancomycin

Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.

CENtral Science

» News, notes, and musings from C&EN

Check out some of the recent posts from C&EN's blog, "C&ENtral Science"


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