Transmembrane Proteins
Quote of the Week
"Processes in nature have decades to evolve—we don't have that luxury. If you're lucky, you have a four-year grant."
R. DAVID HOLBROOK, CHEMICAL ENGINEER, NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGY – p. 44
March 14, 2011
In This Issue:
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Highlights
Cover Story
From Picture To Pill
Debut of G-protein-coupled receptors will bolster drugmakers' tool kits. (pp. 15-21)
» Meet The Structure Specialists
Science & Technology
Inflammation Stokes Cancer (Member Content)
When it goes awry, this defense mechanism can contribute to all stages of cancer progression. (pp. 40-43)
ACS News
Starting Salaries
Chemistry and chemical engineering graduates in 2009 faced a tough job market and falling median salaries. (pp. 49-53)
» To A Degree: Chemical engineering and chemistry grads
Table of Contents
News Of The Week
House Panel Votes To Halt Climate Rules p. 9
Environment: Republicans push antiregulatory agenda.
China Outlines Path Forward p. 10
People's Congress: Business leaders see opportunity in country's next five-year plan.
Nanodiamonds Fight Cancer p. 10
Chemotherapy: Faceted nanomaterials deliver drugs to tumor cells.
Oil Spill's Air Effects Probed p. 11
Deepwater Horizon: Aircraft data show how accident's emissions affected Gulf of Mexico atmosphere.
Gates Foundation Backs Liquidia p. 11
Philanthropy makes its first biotech equity investment.
Senate Rejects House Budget Cuts p. 12
Congress: Legislators remain divided about how much to reduce fiscal 2011 spending.
Poised To React p. 12
Nanoscience: Tethering molecules to gold surface forces reaction.
First Hit For A Cancer Target p. 13
Drug Discovery: Academic collaboration leads to nanomolar inhibitor for phosphatase methylesterase-1.
Crop Protection p. 13
India's Jubilant to commercialize new route to key insecticide intermediate.
Business
Transformed DSM Targets Growth pp. 24-27 (Member Content)
After restructuring, CEO Feike Sijbesma has a four-pronged strategy for expansion.
Stem Cell Surge pp. 28-29 (Member Content)
Cellular Dynamics, a pioneer in induced pluripotent stem cells, is creating a new services sector.
Business Concentrates pp. 22-23 (Member Content)
- Major Kuwait-China Venture Takes Shape
- A $9 billion project to build a refinery and petrochemical complex will likely go ahead in Zhanjiang...
- Oxea Will Boost Carboxylic Acids
- Oxea plans to build a new carboxylic acid plant at its headquarters site in Oberhausen, Germany...
- Albemarle Expanding Bromine Venture
- Jordan Bromine, a Safi, Jordan-based joint venture between Albemarle and Arab Potash, plans to double capacity next year...
- BASF And Evolva Join For Synthetic Biology
- BASF has signed a joint research agreement with Swiss synthetic biology firm Evolva...
- Solvay Hiking Polymer Capacity
- Solvay plans to expand capacity for its Solef polyvinylidene fluoride line at its Tavaux, France...
- BASF Again Mulls Brazilian Acrylics
- BASF is starting a feasibility study for a complex in Brazil that would make acrylic acid...
- GSK Ends Pact With Targacept
- GlaxoSmithKline and Targacept have ended their research collaboration, which was established in 2007...
- Cadila, Holtzman Invest In Rwanda
- Cadila Pharmaceuticals of Ahmedabad, India, and U.S.-based Holtzman Group have formed a pharmaceutical manufacturing joint venture...
- Neste Completes Diesel Plant
- Finland’s Neste Oil has opened the world’s largest renewable diesel plant...
- BMS And WuXi Team Up For Testing
- China’s largest contract research organization, WuXi PharmaTech, will set up a lab in Shanghai...
- Renovo Slashes jobs After Trial Failure
- Renovo is reducing its staff by more than 100 people after negative Phase III clinical trial results for Juvista...
- Eisai Realigns U.S. Operations
- Eisai Inc., the U.S. pharmaceutical subsidiary of Japan’s Eisai Co., is reorganizing its operations...
- Business Roundup
- Bridgestone, Nova Chemicals, Lanxess, Celanese, Amprius, Monsanto, Dow Chemical, Anacor Pharmaceuticals....
ACS News
Starting Salaries pp. 49-53
Chemistry and chemical engineering graduates in 2009 faced a tough job market and falling median salaries.
To A Degree: A Brief comparison of chemical engineering and chemistry grads p. 52
Council Preview pp. 54-55
Election of candidates will be main order of business at ACS National meeting in Anaheim, Calif.
Dance For IYC In Anaheim p. 55
Nominations Open For ACS Fellows p. 55
This Week Online
Government & Policy
ARPA-E Confab Draws Unusual Supporters pp. 32-33 (Member Content)
Key Republican Party leaders back clean energy R&D program.
Biosensors On The Fast Track pp. 34-35
Regulators join forces with developers to speed up approval of transformative devices.
Strengthening Science Abroad p. 36 (Member Content)
U.S. federal agencies examine their role in capacity building in developing countries.
Government & Policy Concentrates p. 30 (Member Content)
- Senate Approves Patent Reform Bill
- The Senate last week gave overwhelming approval to legislation that would overhaul the U.S. patent system for the first time since 1952...
- House Pesticide Bill Advances
- The House of Representatives Agriculture Committee has approved a bill that would amend federal pesticide and water pollution laws...
- Launch of Aerosol-Observing Satellite Fails
- A NASA satellite, Glory, carrying instruments to monitor atmospheric aerosol particles and solar irradiance crashed...
- Chemical Industry Backs Antiterrorism Legislation
- Chemical industry officials welcome the introduction of bills in the Senate and the House of Representatives that would extend the current federal...
- Actions Urged On Deemed Exports
- The Government Accountability Office says that the U.S. needs to better control the issuing of licenses to foreign companies...
» more government & policy news...
Social Networking And C&EN
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Science & Technology
Inflammation Stokes Cancer pp. 40-43 (Member Content)
When it goes awry, this defense mechanism can contribute to all stages of cancer progression.
Moving Up The Food Chain pp. 44-46 (Member Content)
As they transfer to higher organisms in a food web, nanomaterials can increase in concentration, new studies show.
Plastics Release Estrogenic Chemicals p. 48
Study finds that even BPA-free products leach potentially problematic compounds.
Science & Technology Concentrates pp. 38-39 (Member Content)
- Fluoride Blocks For Enzyme
- Blocked active site allows scientists to visualize enzyme-inhibitor complexes that couldn’t be seen before
- Study Suggests New Criteria For Electrocatalysts
- Theoretical findings on O2 reduction energetics should help the selection of better-performing fuel-cell catalysts
- Rhodium-Catalyzed Reaction Pinned Down
- Calculations suggest the C–H activation/Cope rearrangement combo can be customized to deliver multiple chiral products
- Mycobacteria Have A System For Acquiring Iron From Heme
- In addition to using iron-chelating siderophores, the tuberculosis microbe uses a heme-binding protein to grab iron
- … And Can Now Enter The Spotlight For In-Cell Detection
- Scientists unveil the first molecular probe for live, in-cell detection of the pathogenic bacterium
- Nanotube Confinement Boosts Catalysis
- Platinum nanoparticles inside carbon nanotubes are effective catalysts for asymmetric hydrogenations
- Laser-Induced Shock Wave Chromatography
- Proteins and quantum dots can be separated for analysis by the impact induced by a laser shock wave
- Forster Reaction Delivers Generic Drug
- A novel synthetic route to make a hyperparathyroidism drug uses a century-old, unexplored method
» more science & technology news...
Meetings
42nd Middle Atlantic Regional Meeting pp. 56-57 (Member Content)
ACS Hosts Public Relations Workshop p. 57 (Member Content)
2011 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
The Departments
Letters pp. 5-6
Newscripts p. 64
Commemorative Chemistry Stamps
C&EN Archives
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Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
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