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PI3K inhibitors
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Quote of the Week

"Al-Qaeda and other terrorist groups are active in Africa, and it is imperative that deadly pathogens stored in labs there are secure. This is a threat we cannot ignore."
SEN. RICHARD G. LUGAR (R-IND.), RANKING MEMBER AND FORMER CHAIRMAN, SENATE FOREIGN RELATIONS COMMITTEE.p. 30

April 11, 2011

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Highlights

Cover Story

PI3K At The Clinical Crossroads

After a frenzy to develop better and more selective PI3K inhibitors, companies now must figure out how to use them in cancer patients. (pp. 15-19)

Business

Petrochemicals Rise Again

Strong Asian growth has reinvigorated the global petrochemical industry. (pp. 22-23)

Government & Policy

Biosecurity Effort Expands To Africa

U.S. seeks to secure deadly pathogens to prevent their use in bioterror attacks. (pp. 30-32)

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Table of Contents

News Of The Week

Solvay To Buy France's Rhodia p. 9

Specialty Chemicals: $4.8 billion acquisition will create a global powerhouse.

Government Stalls p. 10

Congress: Partisan struggle to set the fiscal 2011 federal budget moves agencies toward closing.

Carbenes Map Protein Surface p. 10

Structural Biology: Highly reactive species nonselectively label amino acids.

Safer Carbonylations p. 11

Synthesis: New approach could ease small-scale carbon monoxide reactions.

Merck Boosts Eye Care Business p. 11

Deal to acquire Inspire Pharmaceuticals underscores specialties merger activity.

Congress Splits On EPA CO2 Bill p. 12

Climate Change: Senate blocks, House backs legislation to ban EPA controls on greenhouse gases.

New Route To Graphene Devices p. 12

Nanoelectronics: Procedure draws on industry-compatible methods and materials.

Business

Petrochemicals Rise Again pp. 22-23 (Member Content)

Strong Asian growth has reinvigorated the global petrochemical industry.

China: New Report Describes Continued Petrochemical Expansion pp. 22-23 (Member Content)

Signed, Sealed, Stored, Delivered pp. 24-25 (Member Content)

BioFocus is pioneering the compound management business.

Pipeline Pitfalls p. 26 (Member Content)

Big pharma's R&D revamping is hitting biotech company partners.

Business Concentrates pp. 20-21 (Member Content)

This Week Online

Probing Probiotic Cheese

Food Science: NMR generates metabolic profiles of probiotic cheeses.

A Faster Way To Diagnose Celiac Disease

Medical Diagnostics: A new biosensor detects celiac antibodies in human serum.

An Emerging Pollutant Circles The Globe

Air Pollution: The first global study finds widespread distribution in air of compounds used in personal care products.

SNP Doesn't Mix With Beer

Chugging large amounts of beer isn't healthy for anyone.

Government & Policy

Biosecurity Effort Expands To Africa pp. 30-32

U.S. seeks to secure deadly pathogens to prevent their use in bioterror attacks.

Government & Policy Concentrates p. 28 (Member Content)

ACS News

ACS In Anaheim pp. 42-43

Photos from the spring national meeting.

ACS Honors Its 50-Year Members p. 44-51

The American Chemical Society and its local sections are honoring those who have been members for 50 years in 2011.

People

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Social Networking And C&EN

Social Networking And C&EN

You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.

Science & Technology

Retooling A Bacterial Biofuel Factory pp. 36-37

ACS Meeting News: Gene swaps tweak kinetics and equilibrium to increase output.

Probing Nanotube Photochemical Properties p. 39

ACS Meeting News: Surprising results question key assumptions about effectiveness of nanotubes in solar cells.

Chiral Route To Key Anticancer Agent p. 41 (Member Content)

First enantioselective synthesis of nutlin-3 could lead to analogs for cancer studies.

Science & Technology Concentrates pp. 34-35

Meetings

2011 C&EN Calendar Web Exclusive

C&EN's latest list of meetings and events of interest to those in the chemical community.

The Departments

Letters pp. 3-4, 6-8

Newscripts p. 56

The Daring World Of Old-School Science

C&EN Archives

C&EN Archives

Now the history of the chemical enterprise is instantly accessible online. C&EN Archives holds the complete collection of C&EN issues dated back from 1923, covering world chemical events, breakthroughs in research, technological advances, business and marketing ventures, government policy, career and education trends, and ACS milestones. With more than 500,000 pages of content, C&EN Archives is instantly accessible and fully searchable, allowing you to discover how the chemical enterprise developed into what it is today.

Head here to discover the past via the C&EN Archives, go to http://pubs.acs.org/cen-archives

Environmental SCENE News

Fertilizer May Help Bacteria Slip Into Groundwater

Water Safety: High phosphate levels allow deadly microbes to pass through soil.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Sunlight Is An Effective Disinfectant

Public Health: Field work shows that a cheap water treatment method improves children's health.

House Takes Aim At Clean Air Act

Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.

Analytical SCENE News

New Method Isolates Membrane Proteins

Protein Purification: Technique separates proteins on a lipid bilayer.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Mapping Drugs In Human Tissue

Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.

Skeletons Come To Light

Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.

Analyzing Nuclear Processes

ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.

JACS Research In C&EN

Indole Changeup Yields Elusive Alkaloid

ACS Meeting News: Cyclization and nitrene insertion star in synthesis.

Prefab Synthesis Moves Ahead

Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.

Multiple Bradykinin States Revealed

The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.

Scaling Up The Axinellamines

A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.

A Revamped Vancomycin

Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.

CENtral Science

» News, notes, and musings from C&EN

Check out some of the recent posts from C&EN's blog, "C&ENtral Science"


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