Vetting The Data
Quote of the Week
"We consider synthetic chemistry to be very outsourceable. Frankly, we don't do any of it in-house anymore."
KERRY L. SPEAR, VICE PRESIDENT OF MEDICINAL CHEMISTRY, SUNOVION PHARMACEUTICAL – p. 48
May 9, 2011
In This Issue:
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Highlights
Cover Story
New Health Research Frontiers
As new genome sequencing technology debuts, pharma researchers step up to challenge of data analysis, frequently in data-sharing consortia. (pp. 17-21)
Business
Top 50 U.S. Chemical Producers (Member Content)
With the recession behind it, U.S. chemical industry girds for growth. (pp. 26-29)
Science & Technology
Saving Space Suits
Conservators try to stop the degradation of NASA's outer space outfits. (pp. 40-41)
Table of Contents
Cover Story
The Next Generation In Genome Sequencing pp. 17-21
Advances in technology create new challenges in data analysis.
Research At The Heretical Edge pp. 22-23
Johnson & Johnson shares a cloud-hosted data management system with its brethren in big pharma.
News Of The Week
Jolting The Diels-Alderase Hunt p. 11
Biochemistry: Newly discovered enzyme could help chemists determine whether Diels-Alder reaction occurs in nature.
Albemarle To Make Lithium p. 12
New Technology: Company claims advance will allow recovery of lithium from Arkansas brine.
Appeals Court Overturns Stem Cell Research Injunction p. 12
Legal: Appeals court says federal funding may continue for work involving human embryonic stem cells while lower-court case proceeds.
Israel's Teva Will Acquire Cephalon p. 13
Pharmaceuticals: Generic drug giant to buy top biopharmaceutical firm.
Energy Department's Patent Sale p. 13
Agency offers deep discounts to spur start-ups to exploit technology developed by national labs.
Porous Polymer Captures CO2 p. 14
Materials: Tetrazole groups in new material selectively snag greenhouse gas.
Academy Elects New Members p. 14
Honors: Ninety scientists join the ranks of the National Academy of Sciences.
Firm Fined For Chemist's Death p. 15
Safety: Sepracor Canada admits lack of lab ventilation in worker fatality case.
Endosulfan Banned Worldwide p. 15
Persistent Pollutants: Certain uses of pesticide can continue until 2017.
Business
Top 50 U.S. Chemical Producers pp. 26-29 (Member Content)
With the recession behind it, U.S. chemical industry girds for growth.
Caveats Temper India's Promise pp. 30-31 (Member Content)
Chemical market grows strongly, but country remains a difficult place to do business.
The New Millipore p. 32 (Member Content)
Linked to Germany's Merck, laboratory tools maker expects to bolster services for the pharmaceutical industry.
Business Concentrates pp. 24-25 (Member Content)
- DuPont Ups Bid For Danisco
- After twice extending its $6.3 billion offer to buy Danisco, DuPont has made a “best and final offer” of $6.6 billion...
- Judge Dismisses Cancer Suit
- A Pennsylvania state court judge dismissed the first of 32 lawsuits charging that chemicals dumped by Dow Chemical’s Rohm and Haas subsidiary caused a number of McCullom Lake...
- LyondellBasell To Boost Ethylene
- LyondellBasell Industries is the latest chemical firm trying to take advantage of the shale gas boom in the U.S....
- Cereplast Building Italian Plant
- Cereplast, an El Segundo, Calif., compounder of biobased plastics, plans to build a 100,000-metric-ton-per-year plastic compounding plant...
- AkzoNobel To Split ICI Pakistan
- AkzoNobel plans to split ICI Pakistan into two separate companies. Its paint business...
- Bayer Plans Upgrades In Germany And U.S.
- Bayer is upgrading facilities at its Krefeld-Uerdingen site, Germany, and in Baytown, Texas...
- Hansen Named CEO At Dow Corning
- Robert D. Hansen, 50, president of Dow Corning, has been named CEO as of May 3...
- DuPont Opens China Auto Center
- DuPont has opened an automotive design and application development lab at its R&D center in Shanghai...
- BASF Licenses Fuel Additive Product
- BASF has acquired a license from Palox Ltd., based in Cyprus, to a new product called Kerojet Aquarius that binds water contained...
- Yale Enters Deals With Biotech Firms
- Yale University has signed two collaborations to help advance drug candidates in development...
- Dow, Oregon State To Alter Tree Genetics
- Scientists at Dow AgroSciences and Oregon State University will work together on advancing tree biotechnology...
- Myriad Will Acquire Rules-Based Medicine
- Myriad Genetics has agreed to acquire Rules-Based Medicine for $80 million in cash...
- Business Roundup
- IHS, SK Capital, Perstorp, Lanxess, BioAmber, Cobalt Technologies, Total, Grifols, AstraZeneca...
This Week Online
Simplifying Pigment Detective Work
Art Conservation: Scientists remove a strong acid treatment in a Raman spectroscopy technique for measuring paint composition.
Watching Garlic Slay Bacteria
Food Science: Spectroscopy reveals bacterial downfall at the hands of garlic.
What Is Chemical Biology?
CENtral Science blogger Sidechain Bob starts a series of posts about the many faces of chemical biology with a look at peptidomimetics.
Examining Anesthetics
Scientists are just beginning to understand the molecular details of anesthesia, which puts an obstacle in the hunt for new and better anesthetic drugs.
Government & Policy
Industry Touts Free-Trade Deals pp. 35-36 (Member Content)
Pact with Colombia would immediately remove tariffs on most U.S. chemical exports.
EPA-Favored Cleaning Products p. 37 (Member Content)
Disclosure is now part of requirements for use of agency's logo on product labels.
Government & Policy Concentrates p. 34 (Member Content)
- Antiterrorism Bill Advances
- A House of Representatives Energy & Commerce subcommittee approved legislation by voice vote last week that would extend through fiscal 2017...
- Endocrine Disrupter Program’s Troubles
- To get timely results from its Endocrine Disruptor Screening Program (EDSP), EPA needs to beef up its management...
- NIST Tallies Tech Transfer Efforts
- An evaluation of government technology transfer activity indicates that from 2005 to 2009, collaborations at federal labs...
- Budget Cuts Impact NIH Grants
- Researchers who are funded by NIH will see their grants decrease by 1% in fiscal 2011...
- EPA Tightens Rules For Lead Smelters
- EPA is proposing stricter emissions standards for secondary lead smelters...
» more government & policy news...
Education
C&EN Talks With David J. Asai p. 44
HHMI education director discusses coming changes in institute’s education funding.
Meetings
42nd Central Regional Meeting pp. 45-46 (Member Content)
Western Regional Meeting Call For Papers p. 47 (Member Content)
2011 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
Saving Space Suits pp. 40-41
Conservators try to stop the degradation of NASA's outer space outfits. With Photo Gallery
Making Connections At NOBCChE pp. 42-43
Two students seek answers to career questions at annual meeting of black chemists and chemical engineers. With Photo Gallery
NOBCChE's 2011 Science Bowl And Fair Web Exclusive
Middle and high school students from Michigan dominate competitions at this year's meeting. With Photo Gallery And Video
Science & Technology Concentrates pp. 38-39
- Tuning In To Microbe Chatter
- Method detects protein receptors involved in detecting chemical words bacteria use to communicate
- Custom Doped Thermoelectrics
- Material with tailored electronic structure exhibits record-setting thermoelectric effect
- Rock Slime Harbors Endocrine Disrupters
- Water Pollution: Slippery scum on stream beds might accumulate hormone mimics
- A Clearer Picture Of Cell Secretion
- Scientists combine electrochemical and optical measurements to study exocytosis
- Dendrimer Treats Joint Inflammation
- Highly branched polymer relieves rheumatoid arthritis symptoms in mice
- Sweetening The Search For Breast Cancer Biomarkers
- Clinical Diagnostics: New method could help reveal cancer-related changes in protein sugar modifications
- Inorganic Caps Give Nanocrystals A Boost
- Replacing organic ligands with inorganic ones selectively boosts electron transport
- Ketenes Finally Give In To Cycloadditions
- Compounds finally join list of unsaturated substrates used in transition-metal-catalyzed cycloadditions
» more science & technology news...
Career & Employment
Managing Outsourcing pp. 48-51
In drug and biotech firms, chemists are working to get more bang out of the CRO buck.
Editor's Page
Nuclear Power p. 5
The Departments
Letters pp. 6-9
Newscripts p. 56
Fresher Urinals, Cancer-Sniffing Dog
C&EN Archives
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Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
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