Anesthetic Drugs
Quote of the Week
"Some people seem to have gotten amnesia of Deepwater Horizon and the horrific BP spill. I don't have amnesia."
KENNETH L. SALAZAR, SECRETARY, DEPARTMENT OF THE INTERIOR – p. 31
August 22, 2011
In This Issue:
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Highlights
Cover Story
Anesthesia's Awakening
Chemistry informs the quest to understand anesthetics and make them better. (pp. 13-20)
» Video: A Different Animal
Government & Policy
Congress Stalls On Oil-Spill Response(Member Content)
Efforts to pass offshore drilling safety legislation have sputtered over the past year. (pp. 31-33)
Science & Technology
Unnaturally Productive(Member Content)
Companies advance development of protein drugs containing unnatural amino acids. (pp. 40-42)
Table of Contents
News Of The Week
Disease Protein's Mistaken Identity p. 7
Biochemistry: Biologists thought α-synuclein was an unfolded monomer, but new research reveals a tetramer. With Video
Cargill Beefs Up Animal Nutrition p. 8
Feed Additives: Firm bests chemical maker DSM with deal for Provimi.
Race And Federal Grants p. 8
Research: Black applicants have lower NIH funding success rates.
A Revamped Vancomycin p. 9
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
Renewable Energy p. 9
Two solar panel manufacturers shutter U.S. operations.
Kicking The Coffee-Ring Habit p. 10
Fluid Mechanics: Shift in particle shape suppresses vexing effect. With Video
Pfizer Wards Off Viagra Challenge p. 10
Pharmaceuticals: Ruling protects exclusivity for blockbuster drug until 2019.
Protests Force Chemical Plant Closure In China p. 11
Environment: Authorities to shut independent aromatics producer.
ACS Wins $1 Million NSF Grant p. 11
Public Outreach: Funds will be used to communicate chemistry's excitement and value to society.
Business
Asia Advances Biosimilars pp. 24-25 (Member Content)
Companies in South Korea, China, and India are scrambling to market generic biopharmaceuticals.
Codexis Undergoes Its Own Evolution pp. 26-28 (Member Content)
The firm is bringing its biocatalyst engineering to industrial processes beyond pharmaceuticals.
Deals Dwindle p. 29 (Member Content)
Chemical deal-making has hit a soft patch, though observers say it is probably only temporary.
Business Concentrates pp. 22-23 (Member Content)
- Sunoco Sale Completes Exit From Chemicals
- Sunoco has agreed to sell its Haverhill, Ohio, phenol plant to Goradia Capital...
- Arkema And CJ Pick Methionine Site
- Arkema and CJ Cheil-Jedang have chosen a site in Kerteh, Malaysia, to build their previously announced complex for a biobased version of...
- PPG Renews Zoo Commitment
- PPG will provide a grant of $6.9 million to the Pittsburgh Zoo & PPG Aquarium over the next 10 years...
- Linde Receives Energy Department Grant
- The U.S. Department of Energy has awarded German industrial gas firm Linde $15 million for research into carbon capture technologies...
- AstraZeneca, Heptares Huddle On GPCR
- AstraZeneca and Heptares have launched a four-year collaboration focused on discovery and development of therapies targeting...
- Chrysler, ZeaChem To Collaborate
- Biofuel firm ZeaChem has signed a memorandum of understanding with the automaker Chrysler to speed up the development of cellulosic ethanol...
- Momentive Adds Proppant Capacity
- Momentive Specialty Chemicals will expand capacity for resin-coated proppants, used in hydraulic fracturing in the oil and gas industry...
- U.S. Imposes Sanctions On Belarusian Firms
- The U.S. government has imposed sanctions on four Belarusian firms owned by Belneftekhim Concern, which the U.S. Department of Treasury says...
- Ampac Fine Chemicals Signs Biodefense Deal
- Ampac Fine Chemicals (AFC)has finalized an agreement with Chimerix to advance commercial-scale manufacturing of the active ingredient in Chimerix’ CMX001...
- Polymer Enables Synthetic Trachea
- A synthetic trachea based on a composite of POSS and PCU—polyhedral oligomeric silsesquioxane and poly(carbonate-urea) urethane...
- Swedish Regulators Seek Drug Standards
- Sweden’s Medical Products Agency(MPA) is calling for stronger environmental standards for the manufacturing of pharmaceuticals that are sold in Europe...
- Roche Invests In Canadian Site
- Roche will spend more than $190 million over the next five years on a pharmaceutical development center in Mississauga, Ontario...
- Cytos Biotech Slashes Staff, Research
- Cytos Biotechnology will reduce its workforce from 82 to about 10, and it is abandoning work on early-stage projects to focus its resources on CYT003-QbG10...
- Business Roundup
- BASF, Dow Chemical, Evonik Industries, Orica’s, GE Healthcare, Amyris, Pfizer and Qiagen, Human Genome Sciences...
ACS News
Helen Free Looks Back pp. 50-52
Recently honored for helping develop diagnostic test strip technology, the vibrant chemist reflects on her career.
This Week Online
Mussels May Strong-Arm Nutrients In Great Lakes
Water Quality: Invasive mussels may disrupt phosphorus flow in Lake Huron.
ACS National Meeting Picks
Want the scoop on newsworthy sessions at the national meeting in Denver? Check out C&EN Picks.
Tadpoles Help Hunt For Better Anesthetics
To help discover new anesthetics with fewer side effects, researchers want to find the proteins that the drugs target.
Some Gulf Spill Hydrocarbons Remain Underwater
Workplace Safety: Soluble hydrocarbons dissolved in ocean, but questions of worker safety, and the fate of less soluble compounds debated.
Government & Policy
Congress Stalls On Oil-Spill Response pp. 31-33 (Member Content)
Efforts to pass offshore drilling safety legislation have sputtered over the past year.
Technology: Oil Firms Develop New Methods To Avoid Another BP Spill p. 32 (Member Content)
British Chemists Are Fuming pp. 34-35
U.K.'s main funding body angers researchers over budget-tightening policies.
Living With Radon p. 36 (Member Content)
Insights: EPA's efforts to save people from radioactivity in their homes have accomplished little.
Government & Policy Concentrates p. 30 (Member Content)
- Scientific Integrity Plans Make Headway
- All federal agencies have submitted, or will soon submit, new scientific integrity policies in final or draft form...
- Carbon Monoxide Standards Retained
- The existing national air quality standards for carbon monoxide adequately protect public health and the environment...
- NSF Launches Four Engineering Centers
- To advance interdisciplinary research and education in collaboration with industry, NSF launched four new Engineering Research Centers last week...
- Administration Pushes Biofuels Production
- President Barack Obama announced a plan last week in which the Departments of Agriculture, Energy, and Navy....
- NIH Moves Genomics Into Clinical Care
- NIH’s National Human Genome Research Institute (NHGRI) will provide $25 million over the next four years to researchers...
» more government & policy news...
ACS Comments
Ensuring The Financial Sustainability And Growth Of ACS p. 48
Step Up And Speak Up For Science p. 49
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
Unnaturally Productive pp. 40-42 (Member Content)
Companies advance development of protein drugs containing unnatural amino acids.
Handheld IR In The Hangar pp. 43-45 (Member Content)
Boeing uses spectroscopy to monitor airplanes made of carbon-based composites.
Heat Defense: Navy Uses IR To Assess Heat Damage To Planes p. 44 (Member Content)
Electronic Skin pp. 46-47 (Member Content)
Ultrathin devices cling to skin like temporary tattoos. With Video
Science & Technology Concentrates pp. 38-39
- Nucleobases From Space
- Exotic purines present the strongest evidence yet that meteorites could have delivered DNA building blocks to Earth
- Anomeric Study Reinterpreted
- A computational study counters the interpretation of previous work describing differences between sugar isomers
- Nanoelectrochemical Maps Make A Debut
- A scanning probe microscopy method helps visualize electrochemical hotspots on electrode surfaces
- Fukushima’s Drifting Isotopes Monitored
- Globally dispersed radioactive iodine and sulfate from the Japanese nuclear reactor don’t appear to pose a health risk.
- Ocean Acidification’s Decalcifying Effects Explained In Detail
- Study provides clearer data on the impact of atmospheric CO2 on the calcium carbonates of coral and shellfish
- Antibiotic Diversity Can Be Controlled On Multiple Levels
- Chemists demonstrate the ability to harness three genetic controls for the selective biosynthesis of antibiotics
- Molecular Gels Sport New Phase Transition
- Solvent molecules expelled from or incorporated into molecular gel networks control the material’s opaqueness.
- Ginseng Compound Curbs Chemo Effects
- Panaxytriol analog helps alleviate the weight loss and nerve damage associated with cancer treatments in mice
» more science & technology news...
Meetings
Spring 2012 ACS National Meeting pp. 53-57 (Member Content)
Divisions issue calls for papers for the March 25–29 meeting in San Diego.
2011 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
The Departments
Letters pp. 5-6
Newscripts p. 64
High-Tech Crop Circles, Rutherford's Atomic Anniversary
C&EN Archives
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Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
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Check out some of the recent posts from C&EN's blog, "C&ENtral Science"
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