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Quote of the Week

"Lab mice have been bred for 300 to 400 generations on the basis of two selection criteria: One is that they don't bite the technician, and the other is that they happily have sex with their siblings."
ROBERT J. BEYNON, PROTEIN CHEMIST, UNIVERSITY OF LIVERPOOLp. 36

October 3, 2011

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Highlights

Cover Story

Bridging The Gap

As big pharma exits early-stage drug development, contract research firms are serving the nonprofit and government institutions that are taking it on . (pp. 14-19)

Government & Policy

Under Siege: DOE's Loan Guarantees(Member Content)

Solyndra's bankruptcy triggers congressional investigation of Energy Department's clean energy policies. (pp. 28-29)

Science & Technology

With Mice, Urine Powers Social Networking(Member Content)

Researchers are learning the secrets of mouse chemical communication by peering into their pee. (pp. 36-37)

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Table of Contents

News Of The Week

DOE Plans Shift In R&D Direction Huntsman Shrinks Its Swiss Presence House Takes Aim At Clean Air Act Untangling Polymer Flow

DOE Plans Shift In R&D Direction p. 9

Review: Transportation-related R&D, electric vehicle development to grow.

White House Honors Scientists p. 10

Awards: Winners of National Medals of Science and of Technology & Innovation include chemical scientists.

Tronox Will Merge With Ore Supplier p. 10

Inorganics: Company says Exxaro unit will enable it to expand to meet demand.

Tweezing Apart Amyloids p. 11

Therapeutics: Small molecule sticks to lysine to unglue protein aggregates.

Drug Discovery p. 11

Expanded initiative will bridge Lilly's internal, philanthropic R&D efforts.

Huntsman Shrinks Its Swiss Presence p. 12

Textile Dyes: Industry migration to Asia continue.

House Takes Aim At Clean Air Act p. 12

Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.

Untangling Polymer Flow p. 13

Modeling: New algorithm closely describes dynamics of polymer melt. With Videos

Catalyst Calculus p. 13

Organic Chemistry: Math teases out ideal balance of catalyst qualities.

Business

Adding Electrolytes pp. 22-23 (Member Content)

New players follow in the footsteps of lithium-ion battery makers to meet surging U.S. demand.

A Media-Savvy Firm p. 24 (Member Content)

SAFC looks beyond fine chemicals to cell culture media for growth.

Business Concentrates pp. 20-21 (Member Content)

ACS Comment

ACS: The Professional Home For Grad Students And Postdocs p. 43 (Member Content)

 

Education

Grad School On The Big Screen pp. 39-40

Higher education goes under the microscope in new 'Piled Higher and Deeper' movie.

Minimalist Chemistry pp. 41-42

Through small-scale experiments, Asian educators increase access to, and safety of, hands-on lab experience. With Videos

This Week Online

Designing Lithium-Ion Batteries To Last

Cathode Materials: Encasing sulfur in nanofibers could help high-energy batteries survive repeated recharging.

Sunlight Is An Effective Disinfectant

Public Health: Field work shows that a cheap water treatment method improves children's health.

Two Drugs Team Up To Slow Breast Cancer

Alone, Pfizer's Aromasin struggles to combat resistant forms of breast cancer. But with the help of Novartis' Afinitor, the drug can slow disease progression, according to new clinical data.

Untangling Polymer Flow

In videos generated by a new computer model, molten low-density polyethylene flows out of a tube and through a narrow gap, spreading rapidly and colorfully.

Government & Policy

Under Siege: DOE's Loan Guarantees pp. 28-29 (Member Content)

Solyndra's bankruptcy triggers congressional investigation of Energy Department's clean energy policies.

Reactive Nitrogen And Climate Change pp. 30-31 (Member Content)

ACS meeting news: Intricacy of nitrogen cycle complicates emissions regulation.

States Continue To Ban Chemicals p. 32 (Member Content)

New laws target bisphenol A, tris (2-chloroethyl) phosphate.

Government & Policy Concentrates p. 26 (Member Content)

Awards

p. 44 (Member Content)

People

Promotions p. 45 (Member Content)

Obituaries

pp. 46-47 (Member Content)

Facebook

Social Networking And C&EN

Social Networking And C&EN

You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.

Science & Technology

With Mice, Urine Powers Social Networking pp. 36-37 (Member Content)

Researchers are learning the secrets of mouse chemical communication by peering into their pee.

Anti-HIV Trojan Horse p. 38 (Member Content)

Agent invites itself into the brain and then inhibits HIV enzyme.

Science & Technology Concentrates pp. 34-35

Editor's Page

Climate Sensitivity p. 5

Meetings

2011 C&EN Calendar Web Exclusive

C&EN's latest list of meetings and events of interest to those in the chemical community.

The Departments

Letters p. 6 (Member Content)

Newscripts p. 56

2011 Ig Nobel Prizes

C&EN Archives

C&EN Archives

Now the history of the chemical enterprise is instantly accessible online. C&EN Archives holds the complete collection of C&EN issues dated back from 1923, covering world chemical events, breakthroughs in research, technological advances, business and marketing ventures, government policy, career and education trends, and ACS milestones. With more than 500,000 pages of content, C&EN Archives is instantly accessible and fully searchable, allowing you to discover how the chemical enterprise developed into what it is today.

Head here to discover the past via the C&EN Archives, go to http://pubs.acs.org/cen-archives

Environmental SCENE News

Fertilizer May Help Bacteria Slip Into Groundwater

Water Safety: High phosphate levels allow deadly microbes to pass through soil.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Sunlight Is An Effective Disinfectant

Public Health: Field work shows that a cheap water treatment method improves children's health.

House Takes Aim At Clean Air Act

Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.

Analytical SCENE News

New Method Isolates Membrane Proteins

Protein Purification: Technique separates proteins on a lipid bilayer.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Mapping Drugs In Human Tissue

Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.

Skeletons Come To Light

Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.

Analyzing Nuclear Processes

ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.

JACS Research In C&EN

Indole Changeup Yields Elusive Alkaloid

ACS Meeting News: Cyclization and nitrene insertion star in synthesis.

Prefab Synthesis Moves Ahead

Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.

Multiple Bradykinin States Revealed

The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.

Scaling Up The Axinellamines

A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.

A Revamped Vancomycin

Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.

CENtral Science

» News, notes, and musings from C&EN

Check out some of the recent posts from C&EN's blog, "C&ENtral Science"


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