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Special Reports

2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998

October 24, 2011

Coverstory: Bryostatins Retain Promise

New results in total synthesis reinvigorate a 40-year-old field of research. (pp. 10-17)

October 17, 2011

Coverstory: Emerging Strategies

Faced with change, pharmaceutical firms shift business mix to generics and emerging markets. (pp. 15-20)

Coverstory: Shifting Generics To The Super Side

Some generic drug makers aim to innovate and create differentiated products in a competitive market. (pp. 22-26)

October 10, 2011

Coverstory: Lipids Take Charge

Mass spectrometry propels the field of lipidomics. (pp. 15-20)

October 3, 2011

Coverstory: Bridging The Gap

As big pharma exits early-stage drug development, contract research firms are serving the nonprofit and government institutions that are taking it on. (pp. 14-19)

September 26, 2011

Coverstory: Getting The Steel Out

Automakers push ahead on energy-saving carbon fiber composites despite questions of economic viability. (pp. 10-14)

September 19, 2011

Coverstory: Breaking In The New

Developers of new polymers are trying to avoid the hazards that have made success difficult for many of their predecessors. (p. 14)

September 12, 2011

Coverstory: High School Science

C&EN examines the impact of dedicated teachers and volunteers, as well as revisions to AP chemistry. (p. 47)

Coverstory: Inspiring Students To Achieve

High school chemistry teachers show that the best way to teach is often by example. (pp. 48-50)

Coverstory: Science Coaches

Under the ACS pilot program, members partner with teachers to fortify their curriculum, inspire students. (pp. 51-53)

Coverstory: Renewing Advanced Placement

The College Board is overhauling the AP chemistry curriculum and exam to focus on conceptual understanding. (pp. 54-55)

September 5, 2011

Coverstory: Covalent Drugs Form Long-Lived Ties

Irreversible inhibitors may provide unique benefits in drug development. (pp. 19-26)

August 29, 2011

Coverstory: Retardant Debate

Sparks fly over the environmental effects of fire retardants used by the U.S. Forest Service. (pp. 11-15)

August 22, 2011

Coverstory: Anesthesia's Awakening

Chemistry informs the quest to understand anesthetics and make them better. (pp. 13-20)

August 15, 2011

Coverstory: Examining Biofuels Policy

Government mandates have shaped the market but not always for the best. (pp. 10-15)

August 8, 2011

Coverstory: Instrumental Efforts

Entrepreneurs take big risks to bring the latest scientific tools to market. (pp. 14-19)

August 1, 2011

Coverstory: Taking It Back

Material makers will have to adapt to help consumer goods firms fulfill product stewardship goals. (pp. 12-15)

Coverstory: Don't Toss It!: Resources abound to help consumers and manufacturers enable responsible reuse and recycling

July 25, 2011

Coverstory: Global Top 50

Chemical producers show surprisingly good profits soon after the recession. (pp. 12-15)

July 18, 2011

Coverstory: Testing Gulf Seafood

After the oil spill, analytical protocols to assess contaminants in seafood found few problems, but the public and some scientists are not reassured. (p. 9)

Coverstory: Instrumentation: Firms Help Meet Demand For Equipment

(pp. 14-15)

July 11, 2011

Coverstory: Electronic Chemicals

Behind the scenes, materials suppliers help make electronics faster, brighter, smaller, cheaper. (p. 9)

Coverstory: Materials Enable Memory Advances

Development of emerging memory architectures relies on material innovations. (pp. 10-13)

Coverstory: A Tiny Problem

Lithography industry extends old technique in face of setbacks with new one. (pp. 14-16)

Coverstory: Bright Outlook For LED Precursor

Large new applications are behind boom in the trimethylgallium business. (pp. 17-18)

July 4, 2011

Coverstory: Facts & Figures Of The Chemical Industry

A leaner chemical industry made the most of a shallow recovery. (p. 33)

Coverstory: A Long Year of Demand Recovery

Cost cutting boosted finances, but it took four quarters for sales volumes to return. (pp. 34-49)

Coverstory: Chemical Sector's Jobless Recovery

A wobbly rebound, high productivity, and pharma mergers prevented employment growth. (pp. 50-51)

Coverstory: Output Ramps Up In All Regions

Chemical production increased markedly over that in 2009, thanks to demand from developing economies. (pp. 55-63)

Coverstory: Growing Economies Pump Up Commerce

Jump in trade was a measure of recovery for the chemical industry. (pp. 64-67)

June 27, 2011

Coverstory: International Year of Chemistry

Chemistry's contributions to the well-being of humanity are being celebrated in 2011. (p. 39)

Coverstory: Chemistry Boosts Global Sustainable Development

Food, environmental, green, and industrial chemistry sectors promote development and education in Africa, worldwide. (pp. 41-45)

Coverstory: Maximizing The Benefits Of Food

With the help of chemistry, we are eating safer, healthier, and more sustainable food than ever before. (pp. 46-51)

Coverstory: Plant Medicines Key to Global Health

Paradigm shifts could improve quality, availability, and sustainability of traditional and nontraditional medicines. (pp. 52-56)

Coverstory: Medicine Quality Faces Challenges

Access, innovation, and globalization: opportunities and hurdles in providing high-quality drugs to the world's population. (pp. 58-61)

Coverstory: Twenty Years OF Green Chemistry

Chemists have worked hard to build awareness of and reduce hazardous chemical use over the past two decades. (pp. 62-65)

Coverstory: Marie Curie

First female chemistry Nobelist owes much of her success to fierce professional and personal determination. (pp. 66-70)

June 20, 2011

Coverstory: After The Break-Up

The end of a partnership with big pharma brings both opportunity and challenge for biotech firms. (pp. 15-20)

June 13, 2011

Coverstory: Building Small

Nanotechnology makes inroads in the construction industry. (pp. 12-17)

June 6, 2011

Coverstory: Bisphenol A

A rift persists between safety assessments of the man-made estrogen mimic. (p. 13)

Coverstory: Debating BPA's Toxicity

The precautionary principle serves as a dividing line in arguments over the safety of bisphenol A. (pp. 14-19)

Coverstory: Exposure Routes Confound BPA Debate

Beyond bisphenol A in food and drink containers, people face many sources of endocrine disrupters in everyday life. (pp. 20-22)

Coverstory: BPA Is Indispensible For Making Plastics

Chemists struggle to find endocrine-disrupter-free alternatives that match bisphenol A's cost and performance. (Web Exclusive)

Coverstory: BPA Chronology

Dozens of &EN articles published since 2007 have covered the BPA story. (Web Exclusive)

May 30, 2011

Coverstory: Improving Peptides

Small firms develop better peptide drug candidates to expand this pharmaceutical class and attract big pharma partners. (pp. 13-20)

Coverstory: Making Peptides At Large Scale

Efficient synthesis is helping to renew interest in the peptide drug market. (pp. 21-25)

May 23, 2011

Coverstory: Japan Rebuilds

Two months after a devastating earthquake and tsunami, Japan's chemical enterprise is on a determined path to recovery. (p. 13)

Recovering Research

Japanese universities, scientific facilities damaged in quake face up to a year to rebuild. (pp. 14-16)

Japan's Chemical Industry Rebounds

Companies are rapidly rehabilitating their facilities but will face power shortages in coming months. (pp. 17-18)

U.S. Boosts Scrutiny Of Nuclear Reactors

Officials say lessons learned from Japan will make nuclear power safer in future. (pp. 19-20)

May 16, 2011

Coverstory: Shock To The System

Big questions about drug safety arise in the wake of rampant supply-chain globalization. (pp. 11-15)

Battle For Europe: API Producers Make Headway In Brussels On Drug Safety Regulations

(p. 13)

May 9, 2011

Coverstory: The Next Generation In Genome Sequencing

Advances in technology create new challenges in data analysis. (pp. 17-21)

Research At The Heretical Edge

Johnson & Johnson shares a cloud-hosted data management system with its brethren in big pharma. (pp. 22-23)

May 2, 2011

Coverstory: Storm Over Silicones

Some cosmetic ingredient makers defend cyclic methylsiloxanes as competitors tout substitutes. (pp. 10-13)

April 25, 2011

Coverstory: Top Instrument Firms

Mergers and acquisitions alter the landscape in C&EN's ranking of leading analytical and life sciences instrumentation companies. (pp. 13-19)

April 18, 2011

Coverstory: Germinating Pesticides

Chemical firms change course in the search for new products for agriculture. (pp. 13-17)

Life After Roundup

Weed Science: The emergence of glyphosate-resistant weeds has put agriculture in a quandary. (Web Exclusive)

Going Mainstream: Biopesticide Producers Look Beyond Organic Growers

(p. 16)

April 11, 2011

Coverstory: PI3K At The Clinical Crossroads

After a frenzy to develop better and more selective PI3K inhibitors, companies now must figure out how to use them in cancer patients. (pp. 15-19)

April 4, 2011

Coverstory: Pittcon 2011

Year of recovery brings increases in conference attendance, mergers and acquisitions, and instrumentation sales. (pp. 37-40)

Coverstory: Analyze This: Mass Spec And Spot Analysis Highlighted At C&EN Pittcon Luncheon

(p. 40)

Coverstory: Carbon-Based Microdevices

Materials from the semiconductor industry allow scientists to 'machine' carbon. (pp. 41-42)

New And Notable At Pittcon

Scientific Instrumentation And More. (pp. 43-46)

New And Notable At Pittcon: Pittcon Editors' Award Winners

(pp. 43-44)

New And Notable At Pittcon: Analytical Instrumentation

(p. 44)

New And Notable At Pittcon: Lab Optimization

(pp. 44-45)

New And Notable At Pittcon: Chromatography & Separations

(p. 46)

New And Notable At Pittcon: Pittcon Potpourri

Thermo Fisher Displays Multiple New Instruments And Bruker Showcases Product Line. (pp. 45-46)

March 28, 2011

Coverstory: Scientist-Diplomat Extraordinaire

Straddling the U.S. and Middle East, Priestley Medalist Ahmed H. Zewail thrives at the interface of science, culture, and international affairs. (pp. 12-16)

Coverstory: Dreaming The Future

(pp. 17-21)

March 21, 2011

Coverstory: Pharma Outsourcing

Successful chemistry outsourcing service providers bring an intellectual contribution to the projects they carry out for their drug company partners. (p. 15)

Coverstory: Giving New Life To An Old Molecule

Case Study #1: Novasep helps Provepharm quickly scale up to make a better pharmaceutical ingredient. (pp. 16-17)

Coverstory: Betting On Boron

Case Study #2: Naeja helps Anacor realize its goal of boron-containing pharmaceuticals. (pp. 18-19)

Coverstory: Rethinking A Renin Inhibitor

Case Study #3: Vitae turns to Solvias for a new synthetic route as well as Phase II clinical production. (pp. 20-21)

March 14, 2011

Coverstory: From Picture To Pill

Debut of G-protein-coupled receptors will bolster drugmakers' tool kits. (pp. 13-18)

Spin-offs: Meet The Structure Specialists

(pp. 18-19)

March 7, 2011

Coverstory: Battling The Bedbug Epidemic

Chemical controls, government action, and personal vigilance are all required to tame the outbreak. (pp. 13-18)

February 28, 2011

Coverstory: More Support For Science

President's 2012 budget proposal provides continued growth for science. (pp. 13-25)

NSF: President Keeps Agency On Doubling Track

NIH: Agency Growth Matches Biomedical Inflation Rate

Defense: Science And Technology Funding Is Down

DHS: Additional Funds For National Security R&D

Energy: Support Up For Renewable Energy

Commerce: Request Provides Gains For Laboratory Services

NASA: Funding Is Flat, But Earth Science Programs Grow

Agriculture: Research Funds Are Down

EPA: Budget Cut, But Gains In Select Areas

Interagency Initiatives: Education, Climate Science, And Nanotech All Grow

February 21, 2011

Coverstory: Big Pharma's Last Shot

Firms hope they can overcome decadelong drop in productivity through efficient innovation. (pp. 12-16)

February 14, 2011

Coverstory: Race To The Pump

Biofuel technologies vie to provide a sustainable supply of transportation fuels. (pp. 11-17)

C&EN Talks With Bruce Dale

Michigan State chemical engineer takes a critical look at the pluses and minuses of biofuels. (WEB EXCLUSIVE)

February 7, 2011

Coverstory: Monitoring The Skies

Field campaigns target the chemistry behind air quality and climate. (pp. 11-15)

Destined For Orbit: Satellite Will Eye Earth's Aerosols

Instrumentation: Aerodyne Spectrometers Ease Particle Research

January 31, 2011

Coverstory: Custom Chemicals

Slowly recovering in 2010, contract manufacturers envision a path toward growth by responding to marketplace shifts. (pp. 13-19)

Coverstory: Fulfilling Capacity

Despite industry-wide consolidation, pharmaceutical companies continue to offer contract manufacturing. (pp. 21-26)

January 24, 2011

Coverstory: Goodbye, Phosphates

Struggling automatic dishwasher detergent manufacturers turn to chemical industry for help with phosphate-free formulas. (pp. 12-17)

January 17, 2011

Coverstory: Technology Renews A Basic Approach

Dried blood spots offer advantages, but also challenges, for pharmaceutical analysis. (pp. 13-17)

January 10, 2011

Coverstory: World Chemical Outlook

The chemical industry predicts better times in 2010. (pp. 9-17)


Cleantech: Venture Capitalists Seek To Lower Risk

Electronic Materials: Growth Will Decelerate After Bumper Year

Finance: Chemical Firms Have Cash To Spend But Are Wary Of Large Investments

Fine Chemicals: Executives See An 'Okay' Year Ahead

Inorganics: After A Rough Spell, Steadier Times Lie Ahead

Instrumentation: Year Ahead Will Test Robustness Of The Recovery

Paints And Coatings: Recovery Will Come Slowly In Developed Economies

Petrochemicals: North American Firms Are Pleasantly Surprised By A Robust Market

Pharmaceuticals: Small, Targeted Deals Will Continue In 2011

Specialties: World Demand Will Grow, Fueled By Asia And South America


Asia: Growth Is Strong, But Clouds Loom

Canada: Chemical Firms Look South And Seek Government Incentives For Growth

Europe: Slower Growth To Follow Strong But Varied Rebound In 2011

Latin America: Buoyant Chemical Companies Keep A Cautious Eye On The Rest Of The World

Middle East: The Region Wants To Beat Its Cracker Addiction

U.S. Weak Domestic Demand Will Be Offset By Strong Exports, Low Natural Gas Prices

January 3, 2011

Coverstory: President's Message

ACS President Nancy Jackson lays out her plan for 2011, the International Year of Chemistry. (pp. 2-4)

» News, notes, and musings from C&EN

Check out some of the recent posts from C&EN's blog, "C&ENtral Science"

» Latest Multimedia

» Videos

June 28, 2010

Nanostructure Dynamics

Imaging: Time-resolved electron tomography provides 3-D views on ultrafast timescale.

May 24, 2010

Dendrimersomes Debut

Supramolecular Chemistry: Self-assembled dendrimer-based structures could deliver drugs, other substances.

May 24, 2010

Dendrimersomes Debut

Supramolecular Chemistry: Self-assembled dendrimer-based structures could deliver drugs, other substances.

May 10, 2010

Lisa P. Jackson

EPA administrator is blazing trails, from regulating greenhouse gas emissions to reforming chemical management policies.

May 24, 2010

Gussman Talks Grub

Sgt. Neil Gussman demonstrates the differences between the military rations of the 1970s and today's Meals, Ready-To-Eat (MREs).

March 22, 2010

An Impasse Grows In Thailand

Political instability stops construction at chemical plants worth billions of dollars.

March 15, 2010

Stirring Liquid Metals Without A Stir Bar

Heat and a magnetic field lead liquid lithium to swirl on its own, like a whirlpool.

March 8, 2010

Carbon-Fixing Enzymes Line Up

Blue-green algae arrange carbon fixation enzyme compartments for maximum efficiency.

March 1, 2010

A World View At India's Dishman

Smart acquisitions and a knack for retaining foreign employees propel growth of drug ingredients producer.

February 8, 2010

Lights, Camera, Chemistry

Learning how to make lab demonstration videos can pay off for instructors and students.

February 8, 2010

Lights, Camera, Chemistry

Learning how to make lab demonstration videos can pay off for instructors and students.

February 5, 2010

Reaction-Driven Mixing

Fluid Dynamics: Chemical interactions drive convection and stirring.

January 15, 2010


Acidic droplet solves maze.

January 11, 2010

Templating A Molecular Donut

Nanotechnology: Molybdenum oxide cluster provides seeding ground to form donut-shaped structure.

» Photo Galleries

April 26, 2010

Gypsy Moths Keep Fluttering

ACS Meeting News: Chemical treatments to rein in invasive pest have evolved, but it's still expanding its range.

April 12, 2010

Marine Life

Photos from a trip to Little Cayman in the British West Indies.

March 22, 2010

An Impasse Grows In Thailand

Political instability stops construction at chemical plants worth billions of dollars.

October 5, 2009

Materials For Adventure

New fibers and membranes make outdoor gear lighter and more comfortable.

September 28, 2009

Getting By On Little Water

Advances in breeding and basic science confer drought tolerance to crops.

April 6, 2009

Scenes From The ACS Meeting In Salt Lake City

A photo spread and slideshow of the 237th National Meeting.

March 23, 2009

Boron Dreams

Priestley Medalist M. Frederick Hawthorne has some unfinished business

February 23, 2009

Pittcon: A Real Cover Story

February 2, 2009

Leather From Another Era

In the Hazaribagh district of Dhaka, Bangladesh, archaic tanneries put workers and the environment at ris

December 15, 2008

Having A Ball With National Chemistry Week

Through hands-on activities, demonstrations, and competitions, kids connect chemistry to sports

» Audio/Podcasts

April 26, 2010

Francis S. Collins

NIH director discusses challenges, opportunities driven by health care reform, stimulus spending, and fast pace of scientific discovery.

March 8, 2010

Skyward View

Five decades of laser technology shine light on chemistry fundamentals.

March 8, 2010

Molecular Dynamics In Real Time

Five decades of laser technology shine light on chemistry fundamentals.

March 8, 2010

Molecules At Surfaces And Interfaces

Five decades of laser technology shine light on chemistry fundamentals.

March 8, 2010

Electron Dynamics

Five decades of laser technology shine light on chemistry fundamentals.

October 5, 2009

Rebecca Kamen

A sculptor nurtures an elemental garden.

March 9, 2009

On The Bubble

Cleantech start-ups and investors weigh the odds of growing during a downturn

February 2, 2009

New Leader Takes Over At NIEHS

Toxicologist Linda Birnbaum charts course for NIH institute

November 17, 2008

Chemistry, Culture, and Camaraderie

The international chemistry olympiad offers an experience worth its weight in gold

November 17, 2008

Happy Birthday, Love Canal

It's been 30 years since the neighborhood surrounding America's most famous toxic waste dump was evacuated, yet its legacy is still unfolding

» Other Multimedia

April 27, 2009

Cellulosic Scale-Up

DOE-backed ethanol producers encounter difficulties converting waste streams to commercially viable fuel.

June 11, 2007

CAS Timeline

100 years of progress from volunteers and index cards to cutting edge computers, see the progress of CAS.

June 11, 2007

The Incredible Vastness of Data

In the hands of CAS, a morass of data points ends up telling epic research stories, page by page.

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