Kendrew used the technique to solve myoglobin; hemoglobin yielded shortly thereafter. And thus began a new field of research. Throughout the 1960s, the structures of carboxypeptidase, papain, chymotrypsin, and ribonuclease began to appear from old and new protein structure labs, while Perutz and Kendrew obtained increasingly better resolution structures of hemoglobin and myoglobin.
by Sarah Everts | September 09, 2013
As far as safety is concerned, the National Institutes of Health has made no distinction between recombinant and synthetic techniques under its research guidelines (C&EN, Aug. 3, 2009, page 23). That’s not to say the public doesn’t want oversight. About 45% of adults said the federal government should regulate synthetic biology research, and 43% said government should develop voluntary research guidelines jointly with industry.
by Ann M. Thayer | June 24, 2013
Muir “” Known for inventing techniques to synthesize unusual proteins that cannot be made genetically, Thomas W. Muir has established himself in the fields of chemistry and chemical biology during his 20-year career. A chemist by training, Muir studies biological signaling processes through the lens of chemistry.
by Sophia L. Cai | March 04, 2013
A new amplification method smooths out sequence biases that hamper the bulk techniques to achieve uniform single-cell genome coverage. X. Sunney Xie, Chenghang Zong, Sijia Lu, and Alec R. Chapman of Harvard University developed the technique they call MALBAC, for multiple annealing and looping-based amplification cycles (Science, DOI: 10.1126/science.1229164).
by Celia Henry Arnaud | December 24, 2012
—An Advance In Directed Evolution “Synthetic Biology: Technique can now be carried out entirely in yeast” Researchers have, for the first time, developed a technique for directed evolution that works completely in yeast. Because yeast cells are eukaryotic, like human cells, the approach could be a powerful new way to engineer humanlike proteins and cell pathways.
by Stu Borman | October 29, 2012
“The ability to generate enzymes is the most powerful technique for providing industrial catalysis today,” says David Dodds, a private consultant who previously directed fermentation and biocatalysis development at Bristol-Myers Squibb. Prior to that, Dodds led Schering-Plough’s biotransformations group.
by Ann M. Thayer | May 28, 2012
Studies on how the animals age and projects that develop analytical techniques to detect why they’re sick will also aid other marine mammals, whether they reside at SeaWorld or out in the wild. Furthermore, investigations of the marine mammals’ wound-healing abilities, as well as unique metabolic diseases they’re afflicted with and novel ocean pathogens they pick up, could eventually benefit human health.
by Lauren K. Wolf | May 07, 2012
At Dow, researchers used traditional and molecular breeding techniques, though they focused on the same pathway, according to David Dzisiak, commercial leader for grains and oils at Dow AgroSciences. “Our plant breeders used two key variations—one was very high in monounsaturates, and they found some experimental canola that has very low levels of linoleic acid.
by Melody M. Bomgardner | March 12, 2012
That’s because conventional techniques for producing the protein and labeling it with phosphate can’t be controlled site-specifically. Hackenberger’s group has now used expressed protein ligation to achieve the first synthesis of tau protein containing a single phosphorylated site on its C-terminus (Chem.
by Lauren K. Wolf | January 23, 2012
These standards will not be legally binding on MAb manufacturers but instead are intended to provide worldwide best practice guidance, says Anthony Mire-Sluis, corporate vice president for product and device quality at Amgen and chair of the USP Recombinant Therapeutic Monoclonal Antibodies Expert Panel, which is developing the standards.
by Jyllian Kemsley | January 16, 2012