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FEATURES |
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Bioinformatics battles breast cancer
Mona Mort
Years of research show that genetic mutations, whether caused by exposure to environmental mutagens or inherited as defective gene copies, are inherent to the onset of cancer. Only about 5% of all incidences of breast cancer can be attributed to defective BRCA1 or BRCA2 genes. Determining the cause of breast cancer in the cases that are not hereditary and searching for other genetic defects leading to breast cancer require large-scale screening of tumor tissue from all types of breast cancer cases, and not just in high-risk families. Producing large quantities of information on cancer genes, and their expression, is a challenge in cataloging the information and making it available. |
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Are drugs for sepsis the "impossible dream"?
Evelyn Strauss
More than 700,000 people in the United States become septic every year and the incidence has been climbing for at least the past 20 years. Decades of research and more than 40 clinical trials have yielded no treatment for sepsis. Despite these failures, researchers' assault on this deadly foe is anything but quixotic. |
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Intuitive data analysis: The next generation
Bill Ladd
High-throughput technology has resulted in the warp-speed production of data. Turning that data into usable information requires an analysis environment that offers access to disparate data sources, visual data displays that promote multidimensional reasoning, and flexible ways to publish data in a collaborative work-group environment. |
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Compound collections get focused
Edward Hodgkin and Kathe Andrews-Cramer
As genomics identifies increasing numbers of novel targets, HTS resources will be in high demand. The ability to screen small, well-designed compound libraries for certain targets will free large-scale HTS for other targets for which a knowledge-based approach is not appropriate.
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DEPARTMENTS |
7 |
Content in Context
Stalwart support
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9 |
Feedback from our readers
- Ferreting out the flu
- Liver replacements
- The cow cure
- Prostate cancer's attraction to bone
- And other topics
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19 |
Insight andAnalysis
The trouble with training |
23 |
To Your Health
Dealing with diabetes |
64 |
Money Matters: Personal
Real estate: The REIT way to invest |
68 |
The Tool Box
Software supports "the scientific conversation" |
71 |
The Time Line Chemist's Bookshelf
Lithium and depression |
75 |
Sites and Software
The importance of being "dotcom" |
79 |
Ready to Read
- Using Antibodies, A Laboratory Manual
- Time to Heal: American Medical Education from the Turn of the Century to the Era of Managed Care
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81 |
New Product Notes |
85 |
On the Calendar |
88 |
Diseases and Disorders
Malaria: Life cycle of a killer |
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