Scanning
the code for combichem(268 KB)
Kevin Braeckmans, Stefaan C. De Smedt, Marc Leblans,
Chris Roelant, Rudi Pauwels, and Joseph Demeester
Multiplex technologies, which enable researchers to carry
out millions of synthetic reactions and biological tests in parallel
on a miniature scale, are useful in fields such as clinical and genetic
analyses and diagnostics. One approach to multiplexing is bead-based
fiber-optic arrays, which use microspheres encoded with fluorescent
dyes. When excitation light is sent through the fibers, the emerging
fluorescence of the beads is captured by the same fibers and sent to
a charge-coupled device camera with optical filters to obtain an image
of the microwell array. Each bead is subsequently identified through
its optical signature.
The virtual patient(148 KB)
by Randall C. Willis
Researchers have developed biomedical Pinocchios on whom
compounds can be tested. Using these computational puppets, or virtual
people, scientists hope to fine-tune real-world assays and, ideally,
eliminate dead-end leads from trials before they are even synthesized.
To that end, model systems have been developed that mimic the various
healthy and diseased states against which the drug candidate is to
be tested.
Content in Context Agincourt(29 KB)
by James F. Ryan
The
Time Line Developing
diuretics(67 KB)
by Richard A. Pizzi
From mercurials to the thiazides, these urine promoters
have proved to be some of the most prescribed therapeutics.
Applications
NoteBook HapMapping
the genome(77 KB)
by David Bradley
International teams of researchers are correlating SNPs with gene locations.
The Business Page Patents
and Property(58 KB)
by David Filmore
Diverse opportunities for patent protection help drive combichem technology.
The Tool Box A
work in process(73 KB)
by Tim N. Warner and Sam Nochumson
Membrane-based chromatography is paving the way for high-throughput
biopharmaceutical processing.