Drug Development
Quote of the Week
"EPA has its foot firmly on the throat of our economic recovery."
REP. FRED UPTON (R-MICH.) – p. 26
January 17, 2011
In This Issue:
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Highlights
Cover Story
Technology Renews A Basic Approach
Dried blood spots offer advantages, but also challenges, for pharmaceutical analysis. (pp. 13-17)
Business
Ethylene From Methane (Member Content)
Researchers take a new look at an old problem. (pp. 20-21)
Government & Policy
Congressional Outlook For 2011 (Member Content)
Energy, environment, and drug safety oversight hearings are likely to dominate first session. (pp. 26-31)
Table of Contents
News Of The Week
DuPont Snaps Up Danisco p. 7
Industrial Biotech: $6.3 billion deal will strengthen DuPont's business in alternative fuels and food ingredients.
CO2 Helps Crystals Change Shape p. 8
Pharmaceutical Chemistry: Polymorphs convert under mild conditions.
EPA Acts On Fluoride p. 8
Regulations: Agency moves to reduce children's exposure to fluoride.
Firms, Feds Blamed For Gulf Oil Spill p. 9
Investigation: Government panel faults lax oversight, poor industry practices for disaster.
Merck Will Revamp Former Schering-Plough Headquarters. p. 9
Pharmaceuticals: Shift of biotech research to Kenilworth will result in 580 manufacturing job cuts.
A New Feat For Gold Catalysts p. 10
Catalysis: Gold-palladium nanoparticles exclusively transform primary C–H bonds.
Europe's Dioxin Scare Widens p. 10
Food Safety: German eggs, poultry, pork are under scrutiny for contamination.
Drug Companies Poised For Growth p. 11
Outlook: Firms at J. P. Morgan conference shift conversation from restructuring to results.
Hungary's Red Mud Catastrophe Packs A Punch On Plants p. 11
Industrial Accident: Sodium salt, more than heavy metals, from the bauxite reservoir spill may hurt crops.
Business
Ethylene From Methane pp. 20-21 (Member Content)
Researchers take a new look at an old problem.
Concentrating On Chemistry p. 23 (Member Content)
Contract pharmaceutical chemicals maker CiVentiChem enjoys steady growth in the U.S. and India.
Business Concentrates pp. 18-19 (Member Content)
- Cleantech Venture Deals Set Record In 2010
- Venture capital investors made 715 deals with cleantech start-ups in 2010, setting a new record for number of deals...
- China’s Bluestar Buying Norway’s Elkem
- The Norwegian firm Orkla has agreed to sell its Elkem subsidiary to China National Bluestar for $2 billion...
- Oxford Spin-Off To Print Solar Cells
- Oxford Photovoltaics, a recent spin-off from Oxford University, has developed printable solar cells...
- Eastman To Sell Methanol Plant
- Eastman Chemical has agreed to sell an idle methanol and ammonia plant in Beaumont, Texas, to Pandora Methanol....
- Showa Denko To Make LCD Cleaning Gas
- Showa Denko has started construction of a 400-metric-ton-per-year plant to produce environmentally friendly carbonyl fluoride (COF2) gas for use in manufacturing liquid-crystal displays...
- Rhodia Expands Guar Derivatives
- Rhodia is buying the guar derivatives unit of Suzhou HiPro Polymers, based in Zhangjiagang, China...
- Linde, Air Products Start HCl Venture
- Linde and Air Products & Chemicals will build a joint-venture facility at Dow Chemical’s Freeport, Texas...
- Italy’s Euticals Will Acquire Archimica
- The Italian pharmaceutical chemicals company Euticals is acquiring Archimica from TowerBrook Capital Partners for an undisclosed sum...
- Enlight Biosciences Creates Entrega
- Enlight Biosciences, a Boston-based firm established by PureTech Ventures and backed by several major pharmaceutical companies, has created an independent company called Entrega...
- Epizyme Signs With Glaxo Drug Program
- Epizyme and GlaxoSmithKline formed an alliance to discover, develop, and market novel small-molecule therapeutics targeting histone methyltransferases (HMTs)...
- Argonne Licenses Cathodes To LG
- Argonne National Laboratory has licensed a composite cathode material to LG Chem for use in General Motors’ new...
- Lilly, Boehringer Partner In Diabetes
- Eli Lilly & Co. and Boehringer Ingelheim will jointly develop a portfolio of diabetes compounds that are in or nearing late-stage development...
- Aurobindo To Sell Unit To Sinopharm
- India-based Aurobindo Pharma will sell Aurobindo Bio-Pharma...
- Business Roundup
- Lanxess, Süd-Chemie, FMC, Evonik Industries, Air Products & Chemicals, Ineos, Qteros, Valero Energy, DSM BioSolutions...
Books
Sowing Seeds Of Doubt pp. 38-39
How some scientists can twist the facts to suit ends other than scientific truth.
Awards
Awards: January 17 pp. 44-50 (Member Content)
- James Bryant Conant Award In High School Chemistry Teaching
- ACS Award In Theoretical Chemistry
- E. V. Murphree Award In Industrial & Engineering Chemistry
- ACS Award For Creative Work In Synthetic Organic Chemistry
- ACS Award In Applied Polymer Science
- ACS Award For Encouraging Women Into Careers In The Chemical Sciences
- Nakanishi Prize
- ACS Award In Separations Science & Technology
- Chemists Receive Presidential Honors
- Collins And vom Saal Win Heinz Awards
- Geochemistry Award to John Tossell
- James Stevens Garners Houdry Award
- Zare And Levine Receive Bernstein Award
- Boudart Award To James Dumesic
- Public Service Award To Jeremy Berg
- Norris Award Seeks Applicants
- Gregory Stephanopoulos Wins BIO Award
- Parravano Award To Guo-Shuh Lee
- Visiting Professor Award To Richard Gross
- Special Recognition
Government & Policy
Congressional Outlook For 2011 pp. 26-31 (Member Content)
Energy, environment, and drug safety oversight hearings are likely to dominate first session.
- Energy & Environment: Controlling CO2 Emissions Remains A Divisive Issue
- Homeland Security: Chemical Plant Regulations are Still Up For Debate
- Consumer Protection: Expect Action On Product, Drug Safety
- Chemical Regulation: TSCA Reform Takes A Backseat
- Patent Reform: Revived Subcommittee To Focus On Intellectual Property
- Trade: Expect Early Approval Of South Korean Trade Deal
- Rail Transportation: Update To Freight Rail Competition Policy Is In The Works
- Science Policy: Oversight And Reauthorization Will Dominate Activity
Government & Policy Concentrates p. 24 (Member Content)
- Bayer Vows To Drop Methyl Isocyanate
- The Bayer CropScience pesticide plant near Charleston, W.Va., will phase out production of methyl isocyanate (MIC) over the next 18 months...
- Army Destroys Chemical Munitions At Anniston
- The Anniston Chemical Agent Disposal Facility in Alabama has completed the elimination of mustard-agent-filled mortars stored at the installation...
- EPA Defers Permits For Biomass Burning
- Electricity generators that burn biomass, such as wood, will get a partial three-year reprieve from new regulatory requirements for large industrial facilities that emit greenhouse gases....
- NIH Urged To Address More Conflicts
- Institutions that receive NIH funding should be required to develop policies and procedures that address institutional financial conflicts of interest...
- Senators Clarify Biosimilars Law
- In a Jan. 7 letter to FDA Commissioner Margaret A. Hamburg, Sens. Michael B. Enzi (R-Wyo.), Kay R. Hagan (D-N.C.), Orrin G. Hatch (R-Utah), and John F. Kerry (D-Mass.) reminded...
» more government & policy news...
ACS Comment
The Power Of Collaboration p. 40 (Member Content)
ACS News
ACS Board Elects Chair, Executive Committee Members pp. 42-43 (Member Content)
Leaders elected and strategic issues considered at December meeting of society's top governance body.
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
IR Spectroscopy With Superbright Light pp. 34-35 (Member Content)
Pacifichem News: Synchrotron beams enable spectroscopists to observe the biochemistry of cells.
Cataracts Via Protein Interactions pp. 36 (Member Content)
Experimental, theoretical tools reveal a new route to the eye disease.
Science & Technology Concentrates pp. 32-33 (Member Content)
- 3-D Nanoscale Chemical Maps Of Teeth
- Tomography analysis reveals compositional differences in microscopic tooth structures
- Interfacial Properties Boost Lasing by Quantum Dots
- Two-monolayer-thin alloy layer in core-shell nanocrystals aids optics applications
- Amoebas Found In Treated Drinking Water Worldwide
- Water Treatment: Free-living amoebas that evade common disinfection treatments can host Legionella and other hazardous microorganisms
- Natural Product Sidesteps Drug Resistance In Yeast
- Enzyme inhibitor could lead to new pharmaceuticals
- Red Blood Cell Mimics Circulate Longer When Flexible
- Cross-linking chemistry imparts bio-like property to hydrogel microparticles
- Arsenate-Phosphate Debate Continues
- Review suggests controversy should stimulate interest in studies of enzyme promiscuity
- Gaseous Carbonic Acid Trapped And Analyzed
- Elusive molecule shown to exist in monomeric and dimeric forms
- One-Pot Method Produces Pyrroles
- Reaction converts aromatic alkynes to heterocycles in presence of palladium catalyst
» more science & technology news...
Meetings
Joseph Francisco Speaks To Saudi Arabian Chapter p. 51 (Member Content)
Faculty Workshops Available p. 51 (Member Content)
Chemistry Symposia At The AAAS Meeting p. 51 (Member Content)
Rubber Expo Details Announced p. 51 (Member Content)
2010–11 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
Editor's Page
Welcome To IYC 2011 p. 3
The Departments
Letters pp. 4-6
Newscripts p. 40
Desert Downpours, Swimming Giraffes, Chemical-Free Smells
This Week Online
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Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
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