Heparin's Shadow
Quote of the Week
"There are thousands of Bhopals waiting to happen in India."
R. BANNERJI, CEO, INDIA'S GUJARAT STATE DISASTER MANAGEMENT AUTHORITY – p. 26
May 16, 2011
In This Issue:
Jump to Table of Contents ↓
Highlights
Cover Story
Risk In The Supply Chain
Regulators and manufacturers are concerned about the growing risk of substandard or criminally adulterated ingredients entering the pharma supply chain. (pp. 11-15)
Government & Policy
Concern Grows Over Rare-Earths Supply (Member Content)
Government tries to respond to U.S. vulnerability in these critical materials. (pp. 28-29)
Science & Technology
Learning To Love The Cloud
Cloud computing could provide faster and cheaper solutions to some problems, but chemists remain wary. (pp. 34-35)
Table of Contents
Cover Story
Shock To The System pp. 11-15
Big questions about drug safety arise in the wake of rampant supply-chain globalization.
Battle For Europe: API Producers Make Headway In Brussels On Drug Safety Regulations p. 13
News Of The Week
Methane Fouls Well Water p. 5
Environment: Study confirms link to gas drilling, as a new panel is formed to study public safety.
Alkermes Buys Elan Business p. 6
Restructuring: Sale of drug formulation unit enables Elan to focus on neurology.
The Promise Of Renewables p. 6
Energy: Governments policies can speed up deployment, IPCC says.
Wiring A Single-Molecule Circuit p. 7
Electronics: Researchers link polymer nanowires to single molecules.
Japan's Chemical Profits Surge p. 7
Annual Results: Earthquake had minimal impact on 2010 results.
Unnatural Backbone Mimics α-Helix p. 8
Peptide Chemistry: γ-Amino acid stabilizes structural copycat.
Perfluorochemicals May Postpone Puberty p. 8
Industrial Pollutants: Children with high blood concentrations of the pollutants reach puberty later.
Waugh, Marks Win Big Prizes p. 9
Honors: John Waugh takes Welch Award, Tobin Marks nabs Dreyfus Prize.
DSM, Roquette Invest In Succinic Acid p. 9
Industrial Biotech: Companies plan Europe's largest facility for biobased production.
Business
Price Hikes Lift Chemical Profits pp. 18-20 (Member Content)
Higher prices and volumes yield strong first‑quarter earnings for chemical makers.
Big Pharma's Pipeline Promise pp. 22-23 (Member Content)
First-quarter results were steady, but drug companies see better times as new products approach commercialization.
Braskem's Push pp. 24-25 (Member Content)
Having consolidated the Brazilian petrochemical industry, firm looks to expand in Latin America and the U.S.
Gujarat Readies For Disaster p. 26 (Member Content)
Indian state beefs up capabilities of emergency response unit.
Business Concentrates pp. 16-17 (Member Content)
- Chemtrade To Buy Marsulex
- Canadian sulfuric acid producer Chemtrade Logistics is buying another Canadian producer of sulfur-based chemicals, Marsulex,...
- M&G Will Build Resin Capacity
- Mossi & Ghisolfi plans to build a 1 million-metric-ton-per-year polyethylene terephthalate (PET) resin plant and a plant to make...
- DuPont Expands Titanium Dioxide
- DuPont has unveiled expansions to boost its capacity of titanium dioxide by 350,000 metric tons per year...
- Tokuyama Augments Polysilicon Project
- Tokuyama will significantly boost the size of the polysilicon plant it is building in Sarawak, Malaysia...
- Germany’s Merck Restarts In Japan
- Merck KGaA resumed normal operations at its Onahama, Japan, production site on May 8...
- Wilmar Sets Alcohols At Huntsman Location
- Wilmar International, a Singaporean agribusiness firm, plans to build a natural alcohol plant at Huntsman Corp...
- Targray To Distribute New Dow Solar Films
- Targray Technology International, a materials supplier to the photovoltaic manufacturing industry, will be the exclusive distributor of Dow Chemical’s...
- DSM Is Buying Vitatene
- DSM will buy Vitatene, a León, Spain-based maker of natural carotenoids, from...
- Honeywell Hikes Blowing-Agent Output
- Honeywell has tripled capacity for hydrofluoroolefin (HFO)-1234ze at its Buffalo site over the past 18 months...
- Dow Expands Epoxies In Germany
- Dow Chemical is expanding liquid epoxy resin (LER) capacity at its plant in Stade, Germany, by 30,000 metric...
- Pfizer Returns Drug To Rigel
- As a result of its decision to trim the number of therapeutic areas in its research portfolio, Pfizer has returned the rights to the allergic asthma drug candidate R343...
- Lonza To Boost Cytotoxic Capacity
- Lonza will invest $27 million to expand cytotoxic manufacturing capabilities at its fine chemicals plant in Visp, Switzerland...
- MicroPhage Staph Test Wins FDA Approval
- FDA has granted clearance to a blood culture test from MicroPhage that detects methicillin-antibiotic-resistant Staphylococcus aureus (MRSA)...
- Business Roundup
- Unigel, Albemarle, PerkinElmer, BASF, Navin Fluorine, Chemtura, Verdezyne, Pfizer...
This Week Online
Dolphins Bear Heavy Loads Of Pollutants
Persistent Pollutants: Some dolphins near Georgia coast carry highest recorded levels of organic pollutants in living marine mammals.
Salmonella Outbreak Linked To Laboratories
Seventy-three people in 35 states recently fell ill from a strain of Salmonella associated with clinical and teaching laboratories, according to a report from the Centers for Disease Control & Prevention.
Introducing Artful Science
C&EN Senior Editor Sarah Everts delves into museum scientists' work to conserve cultural artifacts.
Ozone: Still A Chemical—Or Is It?
C&EN Associate Editor Carmen Drahl tweeted about a curious project that made it to the semifinals of the Google Science Fair: a "chemical-free" way to disinfect hands using ozone.
Government & Policy
Concern Grows Over Rare-Earths Supply pp. 28-29 (Member Content)
Government tries to respond to U.S. vulnerability in these critical materials.
NUFO Gains A Voice pp. 30-31 (Member Content)
The National User Facility Organization advocates for scientists who use federal labs.
Government & Policy Concentrates p. 27 (Member Content)
- FDA Seeks Input On Fees For Biosimilars
- FDA has proposed a user fee program to pay for the agency’s review of the safety and efficacy of biosimilars...
- Switch To Safer Chemicals Could Expand Employment
- Shifting to production of safer substances, buttressed by reform of the federal chemical control law, can boost employment in the U.S....
- Industry Opposes Tax Credit Bill
- The chemical industry is cautioning lawmakers against supporting legislation that would provide an array of tax credits to encourage the production and use of vehicles powered by...
- Chemical Disclosure Sought In Europe
- The European Chemicals Agency (ECHA) is being sued by two nongovernmental organizations for the agency’s failure to release the names of...
- DOE, USDA Biofuel Projects Get A Boost
- The Departments of Agriculture and Energy will invest a total of $47 million over three years in eight R&D projects...
» more government & policy news...
ACS Comment
Globalization, Opportunities, Readiness, And ACS: ACS International Center p. 38 (Member Content)
People
Obituaries pp. 42-43 (Member Content)
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
Learning To Love The Cloud pp. 34-35 (Member Content)
Cloud computing could provide faster and cheaper solutions to some problems, but chemists remain wary.
A Giant Leap For Cell Analysis p. 36 (Member Content)
Mass cytometry boosts the number of single-cell parameters that can be measured simultaneously.
Science & Technology Concentrates pp. 32-33
- Big Squeeze Clears Out Protein Garbage
- A mega cellular enzymatic machine undergoes a large conformational change to spit out its waste
- Chemical Fix For Rare Muscular Dystrophy Flaw
- Compound restores key missing protein to cells taken from a muscular dystrophy patient
- Methane Yields To Supercritical CO2
- Carbon dioxide solvent, coupled with a silver catalyst, provides the right conditions for a successful C–H functionalization
- Deep-Sea Vents Dispense Nutritious Pyrite Nanoparticles
- Iron from pyrite (FeS2) particles delivered over long distances helps feed oceanic bacteria and plankton
- Telomerase Pseudoknots Needed For Catalysis
- The structural feature is determined to be necessary for the RNA portion of this enzyme to be catalytically active
- Dust Removes Ozone From Indoor Air
- Squalene and cholesterol, as major components in dust, react with ozone to help remediate household air
- Cisplatin To Blame For Zinc Deficiency
- When the anticancer drug binds albumin, it blocks the protein’s zinc binding site, causing the chemotherapy side effect
- Supercapacitors Made From Super Carbon
- Carbon material with a 3-D porous structure has exceptional surface area and electrical properties
» more science & technology news...
Meetings
Mass Spectrometry Meeting In Denver p. 39 (Member Content)
June conference will draw 6,500 scientists to Colorado.
2011 Northwest Regional Meeting pp. 40-41 (Member Content)
Midwest/Great Lakes Regional Meeting Call For Papers p. 41 (Member Content)
2011 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
Editor's Page
Celebrate Great Teachers p. 3
The Departments
Letters p. 4
Newscripts p. 48
Pity The Poor Mosquito, Sunscreen Bug Repellant
C&EN Archives
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Head here to discover the past via the C&EN Archives, go to http://pubs.acs.org/cen-archives
Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
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