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Quote of the Week

"You can't hire a team of scientists to do your shopping for you."
JESSICA ALBA; CELEBRITY SPOKESWOMAN; SAFER CHEMICALS, HEALTHY FAMILIESp. 10

May 30, 2011

In This Issue:

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October 24, 2011 Issue
October 17, 2011 Issue
October 10, 2011 Issue
October 3, 2011 Issue

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Highlights

Cover Story

Peptide Therapeutics

Drug class's stock rises as firms solve the problems of stability, delivery, and manufacture. (pp. 13-20, 21-25)

» More on this story
Government & Policy

Whither Sustainable Development? (Member Content)

Recent failure of UN talks raises concerns over likelihood of success of efforts to create a green economy. (pp. 39-41)

Science & Technology

Woodward's Unfinished Work (Member Content)

More than 30 years after his death, a selection of R. B. Woodward’s notes on conducting materials is published. (pp. 46-49)

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Table of Contents

Cover Story

Improving Peptides pp. 13-20

Small firms develop better peptide drug candidates to expand this pharmaceutical class and attract big pharma partners.

Making Peptides At Large Scale pp. 21-25

Efficient synthesis is helping to renew interest in the peptide drug market.

News Of The Week

Ubiquitins In Four-Part Harmony p. 7

Biomacromolecular Synthesis: Tetraubiquitin is the longest protein made chemically.

Streamlining Regulation p. 8

Government: Agencies offer plans for cutting costs, paperwork for businesses.

Vertex Hepatitis Drug Is Approved p. 8

Pharmaceuticals: Stage is set for a heated competition between Vertex and Merck.

Metals Recycling Falls Short p. 9

Sustainability: Recycling rates must rise to conserve, maintain resources, UN report says.

Pharmaceuticals p. 9

Lilly creates new company to assume U.S. rights for sepsis drug.

Watery Magma From The Moon p. 10

Moon's Origin: High levels of water found in ancient lunar magma bubbles add twist to giant-impact theory.

Star Power p. 10

TSCA Reform: Jessica Alba joins push to revise federal chemical law.

Business

Phthalates Face Murky Future pp. 28-31 (Member Content)

As Europe moves toward a ban on some phthalates, producers of the plasticizers look to diversify.

Indena Steps Up pp. 32-34 (Member Content)

Extracts and API producer makes its own drug discoveries to keep ahead of competitors.

Rubber Is Booming In Southeast Asia pp. 35-36 (Member Content)

Elastomer producers set up shop in Singapore and Thailand.

Business Concentrates pp. 26-27 (Member Content)

This Week Online

Old Paint Increases Lead Bioavailability In Dust

Heavy Metals: Survey of Canadian household dust suggests people are unaware of safe methods to remove lead paint.

Microfluidic Chip Identifies Microbes

Clinical Diagnostics: New chip both purifies viruses and detects their DNA.

Conserving Canada's Valuables

Canada may not be rife with Roman ruins and Rembrandt masterpieces, but the country's art and artifacts keep scientists busy at the Canadian Conservation Institute.

Severe Bleeding: When Clotting Isn't Enough

At this month's Mid-Atlantic Regional Meeting of the American Chemical Society, news came of a novel technology to fight profuse bleeding.

Government & Policy

Whither Sustainable Development? pp. 39-41 (Member Content)

Recent failure of UN talks raises concerns over likelihood of success of efforts to create a green economy.

Resources: Boosting Efficiency While Curbing Environmental Harm p. 40 (Member Content)

Capturing Carbon Dioxide p. 42 (Member Content)

Senators question cost, lack of applications for greenhouse gas storage plans.

C&EN Talks With John Schwab p. 43 (Member Content)

An advocate for mentoring young organic chemists will retire from NIH this month.

Government & Policy Concentrates p. 38 (Member Content)

ACS Comment

Redefining The Kilogram And Mole p. 58 (Member Content)

ACS News

IYC Profile: Moldova pp. 59

Chemistry professor Vasile Gutsanu has lived through Soviet and independent rule.

Facebook

Social Networking And C&EN

Social Networking And C&EN

You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.

Science & Technology

Woodward's Unfinished Work pp. 46-49 (Member Content)

More than 30 years after his death, a selection of R. B. Woodward's notes on conducting materials is published.

Synthesis Sees Inflationary Push pp. 50-52 (Member Content)

Historical analysis of inflated yield and purity data in organic synthesis papers points to pressure to produce high-impact results.

Improving Vaccines Aimed At Cancer pp. 53-57 (Member Content)

Scientists use various ways to strengthen immune response to carbohydrate cancer antigens.

Science & Technology Concentrates pp. 44-45

Meetings

2011 C&EN Calendar Web Exclusive

C&EN's latest list of meetings and events of interest to those in the chemical community.

Editor's Page

The Value Of R&D p.5

The Departments

Letters p. 4

Newscripts p. 64

Rogue Robot, Energetic Picnicking, Fire Walking In Sync

C&EN Archives

C&EN Archives

Now the history of the chemical enterprise is instantly accessible online. C&EN Archives holds the complete collection of C&EN issues dated back from 1923, covering world chemical events, breakthroughs in research, technological advances, business and marketing ventures, government policy, career and education trends, and ACS milestones. With more than 500,000 pages of content, C&EN Archives is instantly accessible and fully searchable, allowing you to discover how the chemical enterprise developed into what it is today.

Head here to discover the past via the C&EN Archives, go to http://pubs.acs.org/cen-archives

Environmental SCENE News

Fertilizer May Help Bacteria Slip Into Groundwater

Water Safety: High phosphate levels allow deadly microbes to pass through soil.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Sunlight Is An Effective Disinfectant

Public Health: Field work shows that a cheap water treatment method improves children's health.

House Takes Aim At Clean Air Act

Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.

Analytical SCENE News

New Method Isolates Membrane Proteins

Protein Purification: Technique separates proteins on a lipid bilayer.

Bisphenol A Is Ubiquitous In Receipts

Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.

Mapping Drugs In Human Tissue

Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.

Skeletons Come To Light

Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.

Analyzing Nuclear Processes

ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.

JACS Research In C&EN

Indole Changeup Yields Elusive Alkaloid

ACS Meeting News: Cyclization and nitrene insertion star in synthesis.

Prefab Synthesis Moves Ahead

Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.

Multiple Bradykinin States Revealed

The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.

Scaling Up The Axinellamines

A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.

A Revamped Vancomycin

Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.

CENtral Science

» News, notes, and musings from C&EN

Check out some of the recent posts from C&EN's blog, "C&ENtral Science"


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