New Instrument Makers
Quote of the Week
"This is our fifth report where the annual change in female leadership remained flat. If this trend line represented a patient's pulse, she'd be dead."
ILENE H. LANG, PRESIDENT, CATALYST – p. 22
August 8, 2011
In This Issue:
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Highlights
Cover Story
Instrumental Efforts
Entrepreneurs take big risks to bring the latest scientific tools to market. (pp. 14-19)
» Repeat Start-Up: Entrepreneurial Scientist Perseveres Despite Setbacks.
Science & Technology
A Puzzle Named Bengü Sezen
A historic case of fraud in the chemistry community leaves many questions and issues unresolved. (pp. 40-43)
Science & Technology
Scrutinizing Sunscreens
Lotions containing inorganic nanoparticles draw attention of toxicologists and ire of some consumer groups. (pp. 44-46)
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Table of Contents
News Of The Week
Business Slows In Europe p. 9
Chemicals: Second-quarter results are better than last year's, but firms see demand softening.
More Merck Job Cuts p. 10
Pharmaceuticals: Drug maker heralds a second round of layoffs despite strong second quarter.
Prenylation With A Twist p. 10
Biochemistry: Enzyme catalyzes attachment of hydrophobic modifier to peptides in a new way.
Patenting Human Genes p. 11
Innovation: Appeals court overturns ban on gene patents; biotech industry scores victory.
Formosa Plastics Feels The Heat p. 11
Taiwan's government orders shutdown of group's fire-plagued Mailiao petrochemical facility.
Looking Past Yucca Mountain p. 12
Nuclear Waste: Blue-ribbon panel calls for interim storage of spent fuel.
Science And The Debt Deal p. 12
Politics: Compromise includes cuts that will hit science agencies over the next decade.
Graphene From Garbage p. 13
Materials: Low-value, impure carbon sources yield high-quality graphene.
Heavy-Metal Ring Bags Metal Atom p. 13
Inorganic Chemistry: Heterocycle traps an uncharged palladium atom in an odd host-guest interaction.
Business
Women in Industry pp. 22-23 (Member Content)
Women show marginal gains in this year’s edition of the C&EN survey of female executives.
Indian Firms Spread Their Wings pp. 24-27 (Member Content)
Acquisitions of Western assets demonstrate confidence on global stage.
Taking A Big Step In Virtual Space pp. 28-29 (Member Content)
Schrödinger counts on new investments to help it increase the impact of computational chemistry on drug discovery.
Business Concentrates pp. 20-21 (Member Content)
Expand
This Week Online
Proteins Reveal Their Secrets Under Pressure
NMR Spectroscopy: New device allows chemists to apply pressure to proteins during NMR experiments.
Beating Trypanosomes
Aaron Rowe describes promising drugs that attack trypanosomes, the protozoans responsible for Chagas, and the related disease sleeping sickness.
What's In A Name?
Carmen Drahl reveals the human side of chemistry through the stories of naming these elements and a few Nobel Prize-winning reactions.
MRI Machines Make Music
Transform the annoyingly loud banging of MRI machine noises into tunes like "Smoke on the Water."
Government & Policy
Barriers To Federal Tech Transfer pp. 32-34 (Member Content)
Regulations, policies impede commercialization of research from federal labs.
Commitments Are Running Out p. 36 (Member Content)
Possibilities for new global climate treaty are slim.
Government & Policy Concentrates p. 30 (Member Content)
Expand
» more government & policy news...
ACS Comment
Paying It Forward On Jobs: Members Helping Members p. 52 (Member Content)
ACS News
From The Lab To Capitol Hill pp. 54-55
ACS’s public policy fellows bring chemistry to Congress.
Awardees: ACS Welcomes New Congressional Fellows. p. 55
2011 ACS Fellows pp. 58-60
Society honors 213 members in the third year of its fellows program.
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
A Puzzle Named Bengü Sezen pp. 40-43
A historic case of fraud in the chemistry community leaves many questions and issues unresolved.
Scrutinizing Sunscreens pp. 44-46
Lotions containing inorganic nanoparticles draw attention of toxicologists and ire of some consumer groups.
Biopharma Joins The Doping Battle pp. 48-50 (Member Content)
Companies team up with international drug agency to curb athletes’ use of performance-enhancing drugs.
Science & Technology Concentrates pp. 38-39
- Speedier Enantiomeric Excess
- An achiral copper complex grabs an enantiomer and then undergoes a distinctive rotation to quickly give a positive ID
- DESI Tackles Large Proteins
- Mass spec technique known for analyzing small molecules can now be used to analyze proteins as large as 150 kilodaltons
- Solar-Cell Layer Comes Into View
- Microscopy method reveals the location and morphology of electron donor, acceptor, and blended regions in photoactive layers
- Death Isn’t Sweet For Tumor Cells
- Selectively blocking glucose transport kills kidney cancer cells in mice while leaving normal cells intact
- Ion Channel Guides Blood-Seeking Bats
- Vampire bats decide where to sink their teeth into prey with the help of a heat-sensitive ion channel protein
- Model Cluster Yields Clues On Calcium's Water-Splitting Role
- CA2+ in the Mn-Ca cluster of photosystem II appears to set up Mn4+ to oxidize water
- Screening Drugs for Antimalarials
- High-throughput screening and gene profiling of existing drugs help identify new drug combinations to combat malaria
- Molecular Balances Measure Aliphatic CH-π Interactions
- A family of conformationally flexible molecules gives chemists a means for measuring weak interactions in solution
» more science & technology news...
Meetings
Final Program: 242nd ACS National Meeting
Denver, Aug. 28–Sept. 1.
2011 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
Editor's Page
Sezen, Sames, and Columbia p. 5
The Departments
Letters pp. 6-7
Newscripts p. 96
Backyard Gas, Crafty Chemistry
C&EN Archives
Now the history of the chemical enterprise is instantly accessible online. C&EN Archives holds the complete collection of C&EN issues dated back from 1923, covering world chemical events, breakthroughs in research, technological advances, business and marketing ventures, government policy, career and education trends, and ACS milestones. With more than 500,000 pages of content, C&EN Archives is instantly accessible and fully searchable, allowing you to discover how the chemical enterprise developed into what it is today.
Head here to discover the past via the C&EN Archives, go to http://pubs.acs.org/cen-archives
Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
» News, notes, and musings from C&EN
Check out some of the recent posts from C&EN's blog, "C&ENtral Science"
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