Covalent Drugs
Quote of the Week
"Through patent reform, we can cut the red tape that stops too many inventors and entrepreneurs from quickly turning new ideas into thriving businesses—which holds our whole economy back."
PRESIDENT BARACK OBAMA – p. 44
September 5, 2011
In This Issue:
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Highlights
Cover Story
Covalent Drugs Form Long-Lived Ties
Irreversible inhibitors may provide unique benefits in drug development (pp. 19-26)
Business
Striving For Secure Supply(Member Content)
Custom manufacturers of controlled substances confront unique challenges in a drug market niche. (pp. 30-33)
Science & Technology
Water For Oil(Member Content)
Alberta's oil sands are a vast energy resource, but tapping them comes at the expense of a lot of water. (pp. 56-59)
Table of Contents
News Of The Week
Chemists Convene In Denver p. 11
ACS Meeting News: Chemistry of air, space, and water was meeting theme.
U.S.-Backed Solar Panel Maker Folds p. 12
Bankruptcy: Solyndra got loan guarantee but can't make a profit.
Pfizer Advances Its Pipeline p. 12
Drug Discovery: An approval and key late-stage data restore confidence in the firm's R&D engine.
Modifying Graphene Via A Classic Route p. 13
ACS Meeting News: Textbook reaction offers customized, covalent functionalization of carbon material's properties.
Regulatory Roadblock p. 13
Republicans in Congress promise to block new environmental, labor, and health regulations.
Entrepreneurial Focus Key To Job Creation p. 14
ACS Task Force: Recommendations could lead to 100,000 new jobs in 20 years.
BioAmber Will Expand Succinic Acid Production p. 14
Scale-up: Firm selects Ontario site for intermediate chemical made by fermentation.
Making Greener Flame Retardants p. 15
ACS Meeting News: Environmentally friendly films protect cotton and foam from flames and heat.
Dioxin Report Delayed Again p. 15
EPA splits up the study, meant to guide regulation, and promises a rollout starting next year.
Indole Changeup Yields Elusive Alkaloid p. 16
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
From Dust To Snow p. 16
ACS Meeting News: Study of atmospheric dust may herald changes in weather and climate forecasting.
Business
Striving For Secure Supply pp. 30-33 (Member Content)
Custom manufacturers of controlled substances confront unique challenges in a drug market niche.
Regulations: Agencies Keep Tight Limits On Makers Of Controlled Substances pp. 30-33 (Member Content)
Waters Follows A Narrow Course pp. 34-37 (Member Content)
Scientific instrument maker vows to stick with the separations and analysis businesses it knows best.
Heat-Seeking Division: TA Instruments Leverages Small Buyouts For Growth p. 37 (Member Content)
Proppant Progress
A workhorse for oil and gas extraction sees material advances amid growing demand.
Business Concentrates pp. 28-29 (Member Content)
- Chemical Mergers Advance
- Belgian chemical maker Solvay has almost completed its acquisition of Rhodia, having obtained close to 95% of the French firm’s shares from shareholders...
- Mitsui Changes Route To Isopropyl Alcohol
- Mitsui Chemicals will spend about $40 million to rebuild and expand its isopropyl alcohol facility in Osaka...
- Invista Resolves Butanediol Lawsuit
- Invista has resolved a lawsuit against Frontech and its owner, Ming Wan...
- Lanxess Oxide Helps London See Red
- Buckingham Palace is looking picture-perfect these days thanks in part to an iron oxide pigment manufactured by Germany’s Lanxess...
- Evonik Expands Methyl Methacrylate
- Evonik Industries is planning a series of improvement projects around the world that will expand its annual methyl methacrylate (Michael McCoyA) capacity ...
- Sika Buys Brazilian Adhesives Maker
- Sika will acquire Colauto Adesivos e Massas, a nearly 50-year-old Brazilian maker of adhesives, sealants, and acoustic damping materials...
- UOP Builds Hawaii Biorefinery
- Honeywell’s UOP subsidiary has begun construction on a biofuels demonstration facility at the Tesoro refinery in Kapolei...
- DSM, Sinochem Seal Antibiotics Deal
- DSM and Sinochem have completed a 50-50 joint venture that will own DSM’s anti-infectives business...
- Cyalume Purchases JFC Technologies
- Cyalume Technologies has acquired JFC Technologies, a fine and specialty chemical producer based in Bound Brook, N.J....
- Merck Millipore Will Acquire Amnis
- Merck Millipore, the life sciences division of Germany’s Merck KGaA, will acquire Amnis...
- Biogen, Novo Tap Adimab Technology
- Adimab has added partners looking to exploit its yeast-based antibody discovery technology...
- Fareva To Buy Pfizer Consumer Goods Plant
- Fareva, a contract manufacturer with headquarters in Luxembourg, has agreed to acquire Pfizer’s consumer products facility near Richmond, Va...
- Merck Licenses Zymeworks Process
- Merck & Co. will pay up to $187 million for access to bispecific antibody development technology from privately held Zymeworks....
- Business Roundup
- ADA-ES, Air Products & Chemicals, DMV-Fonterra, J. M. Huber, FMC, Pfizer Nutrition, Mission Therapeutics, Santhera Pharmaceuticals, Tekmira Pharmaceuticals...
Education
A Whiff Of Chemistry pp. 64-65
Camp helps blind teens study science by tapping into their other senses.
This Week Online
Owl Eggs Reveal Complex Pollutant Patterns
Persistent Pollutants: Pollutant levels in owl eggs fluctuate with changes in climate and food sources.
Cheap, Simple Test Spots Protein-Protein Interactions
Biological Assay: Using graphene oxide, a new method could help researchers find peptide-based drugs.
New Device Monitors Oxygen Levels During Surgery
Medical Imaging: By measuring a proxy for blood flow, surgeons could make more-informed decisions.
Special Delivery For A Synthesis Victory
John Wood sent Garg's team a hand-made congratulatory gift: beer glasses with the retrosynthetic scheme etched onto the side.
Government & Policy
Senate To Revisit Patent Reform pp. 44-46 (Member Content)
Bipartisan effort targets overhaul of U.S. patent system.
NIH Grants Show Racial Divide pp. 47-49 (Member Content)
Agency to investigate accessibility to mentoring programs, potential bias in peer review process.
CO2 Sets Record pp. 50-52 (Member Content)
Yearly gain in carbon dioxide emissions for 2010 tops U.S. GDP growth for first time in more than two decades.
Government & Policy Concentrates p. 42 (Member Content)
- Space Station Future In Question
- All six crew members aboard the International Space Station (ISS) may be called back to Earth, leaving the multi-billion-dollar international lab to be controlled remotely...
- Vaccines Linked To Few Health Problems
- A literature review by the Institute of Medicine (IOM) concluded that very few health problems can be clearly associated with vaccines...
- Earthquake Triggers Nuclear Plant Review
- The Nuclear Regulatory Commission last week dispatched a six-member technical inspection team to the twin-reactor North Anna nuclear power station, in central Virginia...
- Army Quickens Pace Of Weapons Disposal
- The Army says its Umatilla Chemical Agent Disposal Depot in northeast Oregon has accelerated the pace at which it is incinerating obsolete mustard blister agent....
- Companies To Add Engineering Interns
- The White House announced last week that 45 corporations have pledged to double the number of engineering internships available at their companies in 2012...
» more government & policy news...
ACS Comments
Chemists Care About Jobs p. 66
Awards
ACS 2012 National Award Winners pp. 69-70 (Member Content)
Funding Available For Green Chemistry Research p. 70 (Member Content)
NAS Seeks Nominations For Awards p. 70 (Member Content)
People
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
Water For Oil pp. 56-59 (Member Content)
Alberta's oil sands are a vast energy resource, but tapping them comes at the expense of a lot of water.
Healing Viruses pp. 61-62
Researchers take cancer-fighting viruses from bench to bedside.
Science & Technology Concentrates pp. 54-55
- Biobased, BPA-Free Epoxies
- ACS Meeting News: Chemists build biobased resins from vegetable oil
- Method Separates Hybrid Nanoparticles
- ACS Meeting News: Chromatographic method purifies complex magnetic nanostructures
- Mass Spec May Bring ‘Bath Salts’ Bust
- ACS Meeting News: Isotope ratio analysis traces feedstock fingerprints in drug syntheses
- Nitric Oxide-Emitting Nanomaterials Kill Microbes
- ACS Meeting News: Silica nanorods hold promise for fighting antibiotic-resistant pathogens
- Molecular Velcro Stems Bloodflow
- ACS Meeting News: Hydrophobically modified chitosan latches onto blood cells and assembles them into a gel
- One Label, Five Microscopies
- ACS Meeting News: Metal nanoparticles can be used as universal probe for many imaging methods
- Understanding Oil- Paint Brittleness
- ACS Meeting News: Metal soaps may be key to why zinc white turns brittle faster than lead White
- Toxins Inspire Drug Delivery Concept
- ACS Meeting News: Copolymers carry RNA therapeutics into cells and release them from cell organelles
» more science & technology news...
Editor's Page
Climate Schizophrenia p. 5
Meetings
2011 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
The Departments
Letters pp. 6-9
Newscripts p. 80
Human Jell-O, Chemical Bananas, Iceberg Transport With Video
C&EN Archives
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Head here to discover the past via the C&EN Archives, go to http://pubs.acs.org/cen-archives
Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
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