Contract Research

Quote of the Week
"Lab mice have been bred for 300 to 400 generations on the basis of two selection criteria: One is that they don't bite the technician, and the other is that they happily have sex with their siblings."
ROBERT J. BEYNON, PROTEIN CHEMIST, UNIVERSITY OF LIVERPOOL – p. 36
October 3, 2011
In This Issue:
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Highlights

Cover Story
Bridging The Gap
As big pharma exits early-stage drug development, contract research firms are serving the nonprofit and government institutions that are taking it on . (pp. 14-19)

Government & Policy
Under Siege: DOE's Loan Guarantees(Member Content)
Solyndra's bankruptcy triggers congressional investigation of Energy Department's clean energy policies. (pp. 28-29)

Science & Technology
With Mice, Urine Powers Social Networking(Member Content)
Researchers are learning the secrets of mouse chemical communication by peering into their pee. (pp. 36-37)
Table of Contents
News Of The Week
DOE Plans Shift In R&D Direction p. 9
Review: Transportation-related R&D, electric vehicle development to grow.
White House Honors Scientists p. 10
Awards: Winners of National Medals of Science and of Technology & Innovation include chemical scientists.
Tronox Will Merge With Ore Supplier p. 10
Inorganics: Company says Exxaro unit will enable it to expand to meet demand.
Tweezing Apart Amyloids p. 11
Therapeutics: Small molecule sticks to lysine to unglue protein aggregates.
Drug Discovery p. 11
Expanded initiative will bridge Lilly's internal, philanthropic R&D efforts.
Huntsman Shrinks Its Swiss Presence p. 12
Textile Dyes: Industry migration to Asia continue.
House Takes Aim At Clean Air Act p. 12
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Untangling Polymer Flow p. 13
Modeling: New algorithm closely describes dynamics of polymer melt. With Videos
Catalyst Calculus p. 13
Organic Chemistry: Math teases out ideal balance of catalyst qualities.
Business

Adding Electrolytes pp. 22-23 (Member Content)
New players follow in the footsteps of lithium-ion battery makers to meet surging U.S. demand.
A Media-Savvy Firm p. 24 (Member Content)
SAFC looks beyond fine chemicals to cell culture media for growth.
Business Concentrates pp. 20-21 (Member Content)
- BASF Fertilizer Business Going To Russia’s EuroChem
- BASF has agreed to sell most of its fertilizer business to Moscow-based EuroChem for about $950 million...
- Evonik Pulls Back IPO, Invests In R&D
- Evonik Industries has once again shelved an initial public offering (IPO) of stock. In April, RAG Foundation, which owns about 75% of the firm...
- Ticona Starts Up Polymer Plant
- Celanese’s Ticona unit has started up a new polyoxymethylene (POM) plant at the Frankfurt Hoechst Industrial Park in Germany...
- DuPont Plans China Fluoropolymer Venture With 3F
- DuPont and Shanghai 3F New Materials have signed a letter of intent for a 50-50 joint venture that will make fluoropolymers in Changshu...
- Amyris And Michelin To Pursue Isoprene
- Amyris has signed an agreement to collaborate with tire maker Michelin on the development of isoprene from plant-based sugars...
- Fulcrum Bioenergy Readies Stock Offer
- Garbage-to-ethanol start-up Fulcrum BioEnergy has filed for an initial public offering of stock worth up to $115 million...
- Renmatix Unveils Biomass Technology
- Renmatix has unveiled details of its Plantrose supercritical hydrolysis process for making industrial sugars from plant biomass...
- China Tightens Rare-Earth Controls
- China’s Ministry of Land & Resources plans to increase its oversight of rare-earth metals production...
- California Gets Lithium Carbonate
- Simbol Materials has begun operations at a 500-metric-ton-per-year high-purity lithium carbonate facility near the Salton Sea in California...
- Kureha Debuts Polyglycolic Acid
- Japan’s Kureha has opened the world’s first commercial-scale polyglycolic acid (PGA) facility at DuPont’s site in Belle, W.Va...
- Rusnano Invests In Cleveland BioLabs
- Cleveland BioLabs will launch an oncology-focused subsidiary called Panacela Labs with support from the Russian Corporation of Nanotechnologies...
- Enzon, NeuroSearch To Slash Jobs
- Enzon Pharmaceuticals is slashing its workforce almost in half and cutting its operating costs to better align resources with its R&D activities...
- BMS, Ambrx Partner On Biotherapies
- Bristol-Myers Squibb is acquiring worldwide rights to research, develop, and commercialize biologics based on Ambrx’ Fibroblast Growth Factor 21 (FGF-21)...
- Business Roundup
- LyondellBasell, PPG Industries, Siluria, Zeachem, Colombiana, Lanxess, Monsanto, Teva Pharmaceutical Industries, RXi Pharmaceuticals ...
ACS Comment
ACS: The Professional Home For Grad Students And Postdocs p. 43 (Member Content)
Education
Grad School On The Big Screen pp. 39-40
Higher education goes under the microscope in new 'Piled Higher and Deeper' movie.
Minimalist Chemistry pp. 41-42
Through small-scale experiments, Asian educators increase access to, and safety of, hands-on lab experience. With Videos
This Week Online

Designing Lithium-Ion Batteries To Last
Cathode Materials: Encasing sulfur in nanofibers could help high-energy batteries survive repeated recharging.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
Two Drugs Team Up To Slow Breast Cancer
Alone, Pfizer's Aromasin struggles to combat resistant forms of breast cancer. But with the help of Novartis' Afinitor, the drug can slow disease progression, according to new clinical data.
Untangling Polymer Flow
In videos generated by a new computer model, molten low-density polyethylene flows out of a tube and through a narrow gap, spreading rapidly and colorfully.
Government & Policy

Under Siege: DOE's Loan Guarantees pp. 28-29 (Member Content)
Solyndra's bankruptcy triggers congressional investigation of Energy Department's clean energy policies.
Reactive Nitrogen And Climate Change pp. 30-31 (Member Content)
ACS meeting news: Intricacy of nitrogen cycle complicates emissions regulation.
States Continue To Ban Chemicals p. 32 (Member Content)
New laws target bisphenol A, tris (2-chloroethyl) phosphate.
Government & Policy Concentrates p. 26 (Member Content)
- Trichloroethylene Is Carcinogenic, EPA Says
- The widely used solvent trichloroethylene (TCE) is carcinogenic to humans, EPA concludes in a scientific assessment...
- NSF Promotes More Workplace Flexibility
- NSF announced a new 10-year plan to provide greater work-related flexibility to women and men in research careers who receive grants from the agency...
- Chemical Stockpile Destroyed At Anniston
- The Army says it has completed the destruction of the chemical weapons stockpile at its disposal facility in Anniston, Ala....
- U.S. Agrees To Take Ukraine’s Uranium
- The U.S. and Ukraine signed a memorandum of understanding on Sept. 26 designed to prevent nuclear proliferation...
- NRC Revises Manual On Scientific Evidence
- The National Research Council (NRC) released the third edition of its “Reference Manual on Scientific Evidence,”...
» more government & policy news...
Awards
p. 44 (Member Content)
People
Promotions p. 45 (Member Content)
Obituaries
pp. 46-47 (Member Content)

Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology

With Mice, Urine Powers Social Networking pp. 36-37 (Member Content)
Researchers are learning the secrets of mouse chemical communication by peering into their pee.
Anti-HIV Trojan Horse p. 38 (Member Content)
Agent invites itself into the brain and then inhibits HIV enzyme.
Science & Technology Concentrates pp. 34-35
- Protein Signaling In Motion
- Mass spectrometry uncovers a crucial tugging action involved in G protein activation
- Silanediols Debut As New Catalyst Class
- Hydrogen bond donor compounds join other metal-free catalysts in the organic synthesis tool box
- Millipede Glow Deters Would-Be Predators
- For the first time, field tests show bioluminescence can function as a warning signal
- Nanostructures Sop Up Radioactive Ions
- Tiny titanate tubes and fibers could remediate contaminated water
- Sour-To-Sweet Miracle Mechanism Revealed
- Japanese researchers learn how African red berry’s glycoprotein alters human taste
- Hybrid Photocatalyst Produces H2Rapidly
- Coupling photosystem I and a cobalt complex yields an inexpensive yet active catalyst
- Enantiomeric Effects Of Pain Drugs Unfold
- Arctic Ozone Loss Qualifies As A Hole
- Ozone depletion in the stratosphere over the Arctic deepens, matching that of the Antarctic
» more science & technology news...
Editor's Page
Climate Sensitivity p. 5
Meetings
2011 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
The Departments
Letters p. 6 (Member Content)

Newscripts p. 56
2011 Ig Nobel Prizes
C&EN Archives

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Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
CENtral Science
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