Pharmaceuticals
Quote of the Week
"History shows that America is at its best when we innovate."
ARUN MAJUMDAR, DIRECTOR, ADVANVED RESEARCH PROJECTS AGENCY-ENERGY – p. 51
October 17, 2011
In This Issue:
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Highlights
Cover Story
Generics On The Rise
As conventional markets wane, pharma firms branch into generic drugs, emerging markets, and so-called supergenerics. (pp. 15-26)
Business
A Sense of Urgency(Member Content)
Call for drug safety pushes the mundane art of supply chain management to the front burner. (pp. 30-32)
Career & Employment
Leaving Home(Member Content)
High unemployment forces young European chemists to seek positions in foreign countries . (pp. 71-73)
Table of Contents
Cover Story
Emerging Strategies pp. 15-20
Faced with change, pharmaceutical firms shift business mix to generics and emerging markets.
Shifting Generics To The Super Side pp. 22-26
Some generic drug makers aim to innovate and create differentiated products in a competitive market.
News Of The Week
Rules For Design p. 9
Materials Science: Guidelines predict structures formed by nanoparticles and DNA linkers.
AstraZeneca Shifts Operations p. 10
Pharmaceuticals: Firm will add manufacturing in China while cutting jobs in the U.S..
Congress Passes Trade Agreements p. 10
Exports: Pacts will help open markets and create manufacturing jobs, advocates say.
Identifying Modified Cells p. 11
Molecular Biology: Technique tags and enriches cells genetically altered by nucleases.
Investment Deterrent p. 11
Venture capital firms say FDA regulations hamper their support of biopharma companies.
Linker-Free Molecular Wires p. 12
Electronics: Metal-carbon bonds increase electrical conductance.
DOE Demands Solar Patents p. 12
Intellectual Property: Bankrupt solar firm developed its manufacturing technology with government grant.
Asymmetry From A Guest p. 13
Stereochemistry: Enzymelike pocket that hosts chiral species controls catalyst's enantioselectivity.
Trade Group's About-Face On BPA p. 13
American Chemistry Council asks FDA to ban bisphenol A in baby bottles and sippy cups.
Business
A Sense of Urgency pp. 30-32 (Member Content)
Call for drug safety pushes the mundane art of supply chain management to the front burner.
Growing Businesses The Scottish Way pp. 33-35 (Member Content)
Development authorities seek to harness industry‑academia cooperation in the life sciences.
An Update On Dow pp. 36-38 (Member Content)
CEO Andrew N. Liveris believes the major pieces are in place to continue the company’s transformation.
Business Concentrates pp. 28-29 (Member Content)
- Cleantech Investment Is Up
- Global venture capital investments in clean technology companies totaled $2.23 billion in the third quarter of this year, rising 12% from the second quarter and...
- PTT Acquires stake in NatureWorks
- Thailand’s PTT Chemical is investing $150 million in polylactic acid (PLA) plastics and fiber maker NatureWorks...
- Solutia To Buy Southwall
- Solutia has inked an agreement to acquire Southwall Technologies for $133 million. Southwall makes films for solar-resistant glass...
- Firms Form Fluorochemical Pact
- Honeywell and Sinochem have formed a 50-50 joint venture to make and sell blowing agents for energy-efficient foam insulation in China...
- Arkema Debuts Glass Alternative
- Arkema has launched a nanostructured acrylic sheet that it says is a lighter alternative to glass for use in cars, photovoltaic panels, and aerospace applications...
- Sibur, Sinopec To Collaborate
- Russia’s Sibur and China’s Sinopec have signed a “memorandum of extended cooperation” for the formation of two new nitrile rubber joint ventures...
- Production Resumes At China Solar Plant
- JinkoSolar Holding has restarted a plant in eastern China that it closed last month when an accidental leak of fluoride waste into an adjacent creek...
- Kuraray Boosts Film for LCDS
- Kuraray will spend $170 million to increase capacity for polyvinyl acetate film at its plant in Ehime, Japan....
- DuPont Starts Up Kevlar Capacity
- DuPont has started up its $500 million Cooper River Kevlar p-aramid fiber facility near Charleston, S.C. ...
- Sumitomo Adds To Electronic Materials
- Sumitomo Chemical will spend about $50 million to double production of gallium arsenide epitaxial wafers at its Chiba Works...
- Roche Secures DNA-Sequencing License
- Roche has licensed technology developed by collaborators Stuart Lindsay of Arizona State University’s...
- Ligand Licenses Drug To Chiva
- Ligand Pharmaceuticals and Chiva Pharmaceuticals, a Chinese biopharmaceutical firm, have entered a global licensing agreement for Fablyn...
- Pfizer Inks Deal With GlycoMimetics
- Pfizer has licensed GlycoMimetics’ GMI-1070 molecule, which FDA has designated an orphan drug and given fast-track status...
- Business Roundup
- AkzoNobel, Dow Chemical China, Haier Group, Milliken & Co., Chemtura, Mitsubishi Rayon, ArborGen, Hybrigenics, Pfizer, Exonhit, Boehringer Ingelheim, Gilead Sciences...
Education
Microscopy For Undergrad Chemists pp. 62-63
New program offers advanced training and first four-year degree in chemical microscopy.
This Week Online
New Brominated Chemicals Detected In Gull Eggs
Environmental Pollutants: The contaminants may be degradation products of flame retardants.
Spying On Single Cells
Microfluidics: A test detects the activity of single enzymes associated with drug resistance in cancer cells.
The Chemistry Of Sepia Photographs
In today's digital world, a single Photoshop click can give a photo a sepia look—the warm, brownish tint found in old photos.
Help CENtral Science Help Students
Join C&EN’s blogging team in a fundraising campaign for public schools in need of chemistry resources. Through DonorsChoose.org. you can contribute money to several schools.
Government & Policy
Modernizing Drug Safety Laws pp. 44-46 (Member Content)
Import concerns, drug shortages enter into debate on reauthorization of user fees.
Unfriendly Skies pp. 48-50 (Member Content)
U.S. carriers challenge EU law controlling airlines' greenhouse gas emissions.
A Flood Of Energy Awards pp. 51-52 (Member Content)
Energy Department marks end of fiscal 2011 with key clean energy loan guarantees, grants.
Government & Policy Concentrates p. 42 (Member Content)
- EPA Revises Interstate Air Pollution Rule
- EPA is proposing to ease air pollution restrictions from a regulation it issued in July....
- OSTP Actions Violated Law
- The White House Office of Science & Technology Policy (OSTP) broke the law when it interacted with Chinese officials earlier this year...
- Senate Passes China Currency Sanctions Bill
- The Senate approved legislation (S. 1619) last week that would require the U.S. to impose punitive tariffs on imports from countries found to be subsidizing...
- NSF Selects Innovation Teams
- The inaugural class of NSF Innovation Corps (I-Corps) awardees was announced on Oct. 6. ....
- Biodefense Plans Progress Slowly
- A new evaluation from the Bipartisan WMD Terrorism Research Center concerning U.S. preparations to respond to a major biological attack finds that...
» more government & policy news...
ACS Comment
Chemistry And The Premedical Curriculum p. 65 (Member Content)
ACS News
ACS Honors Heroes Of Chemistry 2011 p. 67
AstraZeneca and DuPont chemists applauded for breakthroughs.
Obituaries
pp. 68-69 (Member Content)
Social Networking And C&EN
You can now follow C&EN on Facebook. Become a fan and track the latest news and discussions at facebook.com/CENews.
Science & Technology
Improving Shop Safety pp. 56-57
Yale updates policies on machine shop use after student death.
Cleaning Acrylics pp. 58-59
Conservation scientists seek new ways to keep modern paintings looking their best.
Detecting H2S In Vivo p. 60 (Member Content)
Studies could lead to sensitive and selective analyses for tiny signaling agent.
Science & Technology Concentrates pp. 54-56
» more science & technology news...
Career & Employment
Leaving Home pp. 71-73
High unemployment forces young European chemists to seek positions in foreign countries.
Career Development: Demystifying European Professional Designations p. 72
Editor's Page
Throw In The Towel? p. 5
Meetings
2011 C&EN Calendar Web Exclusive
C&EN's latest list of meetings and events of interest to those in the chemical community.
The Departments
Letters pp. 6-7 (Member Content)
Newscripts p. 80
Arsenic Sells, Molecules Tickle The Funny Bone.
C&EN Archives
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Environmental SCENE News
Fertilizer May Help Bacteria Slip Into Groundwater
Water Safety: High phosphate levels allow deadly microbes to pass through soil.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Sunlight Is An Effective Disinfectant
Public Health: Field work shows that a cheap water treatment method improves children's health.
House Takes Aim At Clean Air Act
Pollution: Industry backs cost-benefit analyses of EPA rules, but critics fear assault on public health.
Analytical SCENE News
New Method Isolates Membrane Proteins
Protein Purification: Technique separates proteins on a lipid bilayer.
Bisphenol A Is Ubiquitous In Receipts
Endocrine Disrupters: Researchers detect BPA in every receipt that they collected from seven U.S. cities.
Mapping Drugs In Human Tissue
Clinical Chemistry: Mass spectrometry imaging provides view of an inhaled drug in human lung tissue.
Skeletons Come To Light
Fluorescence Imaging: Monitoring cells as they dissolve bone may lead to disease treatments.
Analyzing Nuclear Processes
ACS Meeting News: Analytical chemists devise ways to watch radioactive streams.
JACS Research In C&EN
Indole Changeup Yields Elusive Alkaloid
ACS Meeting News: Cyclization and nitrene insertion star in synthesis.
Prefab Synthesis Moves Ahead
Organic Chemistry: First stable alpha-boryl aldehydes ease preparation of complex small molecules.
Multiple Bradykinin States Revealed
The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized.
Scaling Up The Axinellamines
A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses.
A Revamped Vancomycin
Medicinal Chemistry: Modified compound shows promise against hard-to-treat bacteria.
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