Science & Technology

December 20, 2010

Chemical Year In Review

(Dec 20, 2010 | Vol. 88 Issue 51 | pp. 13-17)

C&EN highlights the major research achievements of 2010.

C&EN Revisits 2000

(Dec 20, 2010 | Vol. 88 Issue 51 | pp. 18-20)

A decade ago, in its annual Chemistry Highlights feature, now called Chemical Year in Review, C&EN looked at some of that year's key research advances in chemistry. Now, C&EN reporters have revisited six of those highlighted discoveries to see what became of them.

Transforming Toxicology (Member Content)

(Dec 20, 2010 | Vol. 88 Issue 51 | pp. 37-39)

Consortium works to accelerate development of 21st-century toxicology.

C&EN Talks With Naomi Oreskes (Member Content)

(Dec 20, 2010 | Vol. 88 Issue 51 | p. 40)

A Science Historian takes on climate-change skeptics and fights off their attacks.

Chemists Gather For Pacifichem 2010

(Dec 20, 2010 | Vol. 88 Issue 51 | p. 7)

International Meetings: Hawaii once again hosts congress for Pacific Rim chemical societies.

Detecting An Elusive Modified DNA Base

(Dec 20, 2010 | Vol. 88 Issue 51 | p. 8)

Epigenetics: Method maps 5-hydroxymethylcytosine in genome.

Enzyme's Dual Nature Revealed

(Dec 20, 2010 | Vol. 88 Issue 51 | p. 9)

Enzymology: Structure shows taxadiene synthase contains domains from two enzyme classes.

Duke University Wraps Up Misconduct Inquiry

(Dec 20, 2010 | Vol. 88 Issue 51 | p. 9)

Investigation: School draws ire for not disclosing results of its probe of a faculty biochemist.

Science & Technology Concentrates (Member Content)

(Dec 20, 2010 | Vol. 88 Issue 51 | pp. 35-36)

• Soapy Separations
• Detergent film transports one enantiomer of a small molecule
• Nanocrystal Imaging Via X-ray Lasers
• Ultrashort light bursts predicted to outpace lattice damage
• RepeatedIcing Puts The Freeze On Ice-Repellent Surfaces
• Surface properties may limit anti-icing nature of superhydrophobic materials
• Nanoparticles Accumulate In Food Chain
• Gold becomes concentrated as it moves from plants to herbivores
• Long-Proposed Porphyrin Is Finally Made
• Near-infrared absorber may find use optics applications
• New Protein Modification Is Uncovered
• Posttranslational process adds succinyl group to lysine
• Black Carbon Declines With Diesel Emissions
• Stricter regulations in California yield quick results
• New Format For Atomic Weights
• Mass interval reflects natural variations in isotope abundances

December 13, 2010

Chemistry In The Spotlight

(Dec 13, 2010 | Vol. 88 Issue 50 | pp. 14-21)

National Chemistry Week demystifies the role of chemistry in movies and on television.

Our Microbial Selves

(Dec 13, 2010 | Vol. 88 Issue 50 | pp. 32-35)

Projects to tabulate communities of bacteria that cohabit our bodies reveal unexpected roles in health and disease.

For Gathering Storm, Clouds Ahead (Member Content)

(Dec 13, 2010 | Vol. 88 Issue 50 | pp. 36-37)

China must overcome significant challenges to become the innovative scientific powerhouse it wants to be.

Arsenic Bacteria Breed Backlash

(Dec 13, 2010 | Vol. 88 Issue 50 | p. 7)

Controversy: Claim that microbe weaves arsenic into its DNA comes under fire.

Peering Into A Battery

(Dec 13, 2010 | Vol. 88 Issue 50 | p. 9)

Materials Science: Technique enables direct look at electrode transformations during charging.

Cell-Mediated Computation

(Dec 13, 2010 | Vol. 88 Issue 50 | p. 11)

Synthetic Biology: Engineered cells can be combined into complex circuits, researchers show.

Science & Technology Concentrates (Member Content)

(Dec 13, 2010 | Vol. 88 Issue 50 | pp. 30-31)

• Model Self-Assembly
• Molecules that self-assemble form 2-D networks through a discrete series of intermediate stages
• Water Destabilizes Protein-Hydrophobic Ligand Complexes
• The first quantitative comparison of dissociation rates of solvated and nonsolvated complexes gives surprising results
• Chemical ‘Nanofuse’
• A conducting molecule that switches off when jolted with electricity functions as a molecular fuse
• Porous Compounds Prefer Paraffins
• Metal-organic frameworks can selectively separate paraffins from mixtures with olefins
• DESI Probes Reactive Intermediates
• Desorption electrospray ionization tracks reactions that are otherwise difficult to follow by mass spectrometry
• Drought Boosts Resveratrol In Cabernets
• A water deficit boosts production of one form of the beneficial compound resveratrol in wine grapes
• Metal-Free Selective Oxidations
• Boron-doped polymeric carbon nitride mediates oxidation of aliphatic C–H moieties under mild conditions
• One-Pot Sulfonylated Pyridines
• Process chemists report a concise synthesis of valuable building blocks used in medicinal and agricultural chemistry

December 6, 2010

New Fibers For Foods

(Dec 6, 2010 | Vol. 88 Issue 49 | pp. 38-40)

Researchers and food manufacturers are developing ingredients to address consumer nutritional needs.

What's In A Food? Defining And Testing For Fiber

(Dec 6, 2010 | Vol. 88 Issue 49 | p. 39)

Researchers and food manufacturers are developing ingredients to address consumer nutritional needs.

Cracking An Interstellar Mystery (Member Content)

(Dec 6, 2010 | Vol. 88 Issue 49 | pp. 41-42)

Chemists identify a possible first molecule in diffuse interstellar bands.

Meta Reaction Revisited (Member Content)

(Dec 6, 2010 | Vol. 88 Issue 49 | pp. 43-44)

Scientists reassess copper's role in a reaction on aromatic rings.

Sezen Found Guilty Of Fraud

(Dec 6, 2010 | Vol. 88 Issue 49 | p. 10)

Scientific Misconduct: Columbia University case is one of the worst for chemistry.

Tuning Up For A Breakdown

(Dec 6, 2010 | Vol. 88 Issue 49 | p. 11)

Biomaterials: Acid-sensitive polymers permit tight control over degradation for in vivo drug delivery.

Coal Ash Spill In Tennessee Still A Problem

(Dec 6, 2010 | Vol. 88 Issue 49 | p. 13)

Environmental Disaster: High levels of arsenic linger downstream of the site of a 2008 accident.

New Rubber Beats Heat And Cold

(Dec 6, 2010 | Vol. 88 Issue 49 | p. 13)

Materials: Nanotube rubber maintains its viscoelasticity in extreme temperatures.

Science & Technology Concentrates (Member Content)

(Dec 6, 2010 | Vol. 88 Issue 49 | pp. 36-37)

• Microbe Thrives on Arsenic
• Discovery indicates that more than six elements might be able to sustain life
• Citrate Stabilizes Bone Apatite
• Apatite nanocrystals that give bone its desirable mechanical properties draw unexpected support from citrate molecules
• Experimental Evidence For ‘Hyperaromaticity’
• Scientists report the first definitive evidence for aromaticity in benzenium and other arenium ions
• Aptamer-Graphene Combos Pull Analytic Double Duty
• Small-molecule-binding nucleic acids conjugated to graphene oxide improve detection of cocaine and other analytes
• Finding Fluoride Via Electron Transfer
• An unusual anion-π orbital interaction is the basis of a chemical sensor that changes color in the presence of fluoride
• Metal-Methane Insertion Milestone
• Microwave spectroscopists have captured the first detailed structure of a transition metal inserted into a C–H bond of methane
• Kinase’s Oscillatory Behavior Controls Cell Signaling
• Protein kinase A forms an oscillatory signaling circuit that represents a new mechanism of signal transmission in cells
• Water Influences Amyloid And Prion Aggregation Rates
• Peptide aggregation in aqueous solution depends on the rate of formation of a dry interface between the biomolecules

November 29, 2010

Close Quarters

(Nov 29, 2010 | Vol. 88 Issue 48 | pp. 9-13)

Crowded conditions such as those in cells can affect proteins' structure, function, and activity.

Online Outreach (Member Content)

(Nov 29, 2010 | Vol. 88 Issue 48 | pp. 34-35)

Chemists are taking to web tools to fulfill 'broader impact' requirement in NSF grants.

Mismatch Route To Targeted Therapy (Member Content)

(Nov 29, 2010 | Vol. 88 Issue 48 | p. 36)

RNA with less than perfect complementarity blocks expression of Huntington's Disease gene sequence.

Imaging Molecules On Living Cells

(Nov 29, 2010 | Vol. 88 Issue 48 | p. 37)

Click-chemistry technique provides a nontoxic way to visualize biomolecules on cell surfaces in vivo.

Yeast Ribosome Structure Solved

(Nov 29, 2010 | Vol. 88 Issue 48 | p. 5)

Crystallography: Details of translation machinery could help elucidate mechanism, regulation.

In Search Of Cysteines

(Nov 29, 2010 | Vol. 88 Issue 48 | p. 8)

Chemical Biology: New technique finds superreactive cysteines in proteins.

Science & Technology Concentrates (Member Content)

(Nov 29, 2010 | Vol. 88 Issue 48 | p. 33)

• Hollow Graphene Spheres
• Layer-by-layer deposition over a polystyrene bead template leads to a new type of graphene structure
• Building Boggsite
• Phosphazenes help guide the formation of pores and channels for synthesizing the rare zeolite mineral
• Popcorn Lung Triggers Laid Bare
• Scientists present the first structural glimpse of diacetyl-arginine adducts, which could help determine diacetyl toxicity
• Imaging Pinpoints Nanoparticle Atoms
• Combining TEM and computer simulations provides an intimate analysis of bimetallic cluster catalysts
• Hartley 2 Reveals More Surprises
• The comet’s tail is composed largely of CO₂, but its nucleus is surrounded by “dandelion puffs” of water ice

November 22, 2010

Rechargeable Metal-Air Batteries (Member Content)

(Nov 22, 2010 | Vol. 88 Issue 47 | pp. 29-31)

Electrochemical cells offer big payout, but production is years away.

Hydrogen Bond Reformulation (Member Content)

(Nov 22, 2010 | Vol. 88 Issue 47 | pp. 32-33)

Proposed new definition broadens the qualifying chemical associations.

Ultrasensitive Detection (Member Content)

(Nov 22, 2010 | Vol. 88 Issue 47 | p. 36)

Three groups use absorption to detect single molecules at room temperature.

Ice Repellent

(Nov 22, 2010 | Vol. 88 Issue 47 | p. 6)

Nanotechnology: Small structures keep water off supercooled surfaces.

Bedding Down Stem Cells

(Nov 22, 2010 | Vol. 88 Issue 47 | p. 7)

Chemical Biology: Fully synthetic structure supports growth of human pluripotent stem cells.

Dopamine Show-And-Tell

(Nov 22, 2010 | Vol. 88 Issue 47 | p. 8)

Structural Biology: First close-up of a dopamine receptor could aid drug discovery.

Growth Laws Call Shots

(Nov 22, 2010 | Vol. 88 Issue 47 | p. 8)

Synthetic Biology: Linear relationships explain cell response during fermentation.

Science & Technology Concentrates (Member Content)

(Nov 22, 2010 | Vol. 88 Issue 47 | pp. 27-28)

• Speedier Electron Transfer
• By strengthening the interface between two proteins, researchers quicken the pace of long-range electron transfer
• Cyclobutadiene Controversy
• Some researchers are questioning last summer’s report on the first X-ray crystal structure of the molecule
• Rubber Additive Forms Potent Skin Allergens
• Enzymes in human skin convert a neoprene processing compound into irritating metabolites
• Astronomers Crack Spectral Mystery
• Astrochemists might have identified the first molecule in the sea of compounds that permeate diffuse interstellar space
• Method Preps Neurotoxic Oligomers For Study In Vitro …
• Researchers use peptide oligomers as seeds to reproducibly generate tau protein aggregates for studying brain diseases
• … And Designed Ligands Target Metal-Amyloid-β Species
• Small molecules could help probe the role of metals in the formation and neurotoxicity of Alzheimer’s protein aggregates
• Light Drives Colorful MOF Modification
• The chemical nature of a metal-organic framework is altered by photochemically removing protecting groups
• Nickel Complex Boosts Hydrogen Oxidation
• An improved nickel diphosphine complex speeds up key fuel-cell reaction

November 15, 2010

Battling Bat Fungus

(Nov 15, 2010 | Vol. 88 Issue 46 | pp. 39-41)

Scientists search for answers to an epidemic that is wiping out bats.

Quantum Cascade Lasers (Member Content)

(Nov 15, 2010 | Vol. 88 Issue 46 | pp. 42-43)

Young technology is the next big thing in molecular spectroscopy.

Perspective: Intangible Rewards

(Nov 15, 2010 | Vol. 88 Issue 46 | pp. 44-45)

Engaging with chemists of the developing world is a responsibility that brings deep satisfaction.

Eurasia-11

(Nov 15, 2010 | Vol. 88 Issue 46 | Web Exclusive)

Behind the scenes with Amal Al-Aboudi.

Elusive Enzyme Species Trapped

(Nov 15, 2010 | Vol. 88 Issue 46 | p. 7)

Enzymology: Independent teams characterize key intermediates in cellular oxidations.

Chlorinated Flame Retardant Travels The Globe

(Nov 15, 2010 | Vol. 88 Issue 46 | p. 8)

Toxic Substances: Evidence arises that Dechlorane Plus can be transported to the poles.

Reactome Retraction

(Nov 15, 2010 | Vol. 88 Issue 46 | p. 11)

Interdisciplinary Research: Authors of controversial array work withdraw paper from Science.

Science & Technology Concentrates (Member Content)

(Nov 15, 2010 | Vol. 88 Issue 46 | pp. 36-37)

• Idle Time For Solar Cells
• Harvard’s Clean Energy Project harnesses computer downtime to screen candidate organic photovoltaic materials
• BN-Fused Indole Debuts
• Chemists have created a variant of the ubiquitous and synthetically important molecule indole
• Venus Flytrap’s Eating Habits
• The plant uses a pair of chemicals to ensure that potential prey is indeed ruffling the trigger hairs in its mouth
• Transdermal BPA Exposure Confirmed
• Studies show that BPA is absorbed through the skin and that cashiers who constantly handle receipts have higher exposure
• RNA Editing Enhances DNA Repair
• Researchers discover a reaction that may play a role in repairing DNA damaged by an inflammatory response
• Ruthenium’s Turn For Z-Selectivity
• Ruthenium olefin cross-metathesis catalysts join molybdenum versions that improve selectivity for functionalized Z alkenes
• Solid Carbon Sources Lead To Graphene
• Method converts table sugar, polymers, and other organic compounds to monolayer carbon films
• Trifecta Chemistry Fashions Prebiotic Purine Precursors
• A three-component reaction suggests a pathway by which all four RNA building blocks might have arisen

November 8, 2010

Celebrating Science And Engineering

(Nov 8, 2010 | Vol. 88 Issue 45 | pp. 50-51)

National festival personalizes scientists and engineers and puts their work in the public spotlight.

Building Bridges (Member Content)

(Nov 8, 2010 | Vol. 88 Issue 45 | p. 52)

Leading Chinese and U.S. analytical chemists gather for community building.

What's That Stuff? Hair Straighteners

(Nov 8, 2010 | Vol. 88 Issue 45 | p. 54)

Cross-linkers, redox chemistry, or high pH, all in the name of beauty.

Holographic Video

(Nov 8, 2010 | Vol. 88 Issue 45 | p. 10)

Materials Science: Photorefractive polymer enables 3-D video.

Jack-Of-All-Trades Detergents

(Nov 8, 2010 | Vol. 88 Issue 45 | p. 12)

Biochemistry: Versatile molecules aid multiple stages of membrane-protein structure determination.

Halogenation In The Garden

(Nov 8, 2010 | Vol. 88 Issue 45 | p. 13)

Synthetic Biology: Chemists integrate carbon-halogen bond formation into plant metabolism.

Science & Technology Concentrates (Member Content)

(Nov 8, 2010 | Vol. 88 Issue 45 | pp. 48-49)

• Dyeing For Green Textiles
• By incorporating a chromophore into an aluminum polymerization catalyst, chemists can now prepare colored polymers in just one step
• Scientists Confirm BPA Levels In Food
• The first data on bisphenol A (BPA) levels in U.S. food to appear in a peer-reviewed journal have been published in Environmental Science & Technology
• Thin Films Made Easy
• Transparent thin films of conducting polymer nanofibers can be deposited onto various materials by means of a solution-based procedure that is simpler, less expensive, and quicker than common deposition methods
• Polymer Films Bend In The Spotlight
• A polymer film that bends in response to light may provide engineers with a new class of soft materials for artificial muscles and other three-dimensional devices
• New Cell-Death Pathway Found
• Disease-related misfolded proteins trigger a previously unknown apoptotic pathway, researchers report
• Spinning Both Ways
• Using a flash of light, a bit of base, and principles of molecular chirality, researchers led by Ben L. Feringa of the University of Groningen, in the Netherlands, have designed a rotating molecular motor
• Stopping Gut Microbe SideSteps Cancer Drug’s Side Effect
• Blocking a bacterial enzyme alleviates a dangerous side effect of a colon cancer drug in mice, according to a multi-institutional research team
• Amyloid Fibrils Grow Asymmetrically
• Structural models have predicted that amyloid fibrils, which are associated with and may help cause conditions such as Alzheimer’s disease, grow symmetrically at both ends

November 1, 2010

The GPU Revolution

(November 1, 2010 | Vol. 88 Issue 44 | pp. 27-29)

Designed for video games, graphics processing units bring once-impossible simulations within reach for chemists.

Fertilization Formula

(November 1, 2010 | Vol. 88 Issue 44 | pp. 30-31)

Researchers step closer to the molecular mechanism behind the sperm and egg union.

And The Winners Are...

(November 1, 2010 | Vol. 88 Issue 44 | pp. 32-33)

Photo contest draws lively response and cool images from C&EN readers.

Forging Ligands

(November 1, 2010 | Vol. 88 Issue 44 | p. 6)

Organometallics: Custom hybrid chelating system could have many uses.

Don't Blame The Pill

(November 1, 2010 | Vol. 88 Issue 44 | p. 6)

Water Pollution: Only a small fraction of the estrogen pollution found in waterways comes from oral contraceptives.

Revealing How Plants Breathe

(November 1, 2010 | Vol. 88 Issue 44 | p. 7)

Structural Biology: An ion channel that controls opening, closing of pores in leaves has a rare protein fold.

Probing Human Genetic Variation

(November 1, 2010 | Vol. 88 Issue 44 | p. 8)

Genome Sequencing: Consortium improves catalog of human DNA differences.

Carbon Capture By Soli

(November 1, 2010 | Vol. 88 Issue 44 | p. 9)

Porous Crystals: Study uncovers details of CO2-binding sites in framework compounds.

Science & Technology Concentrates (Member Content)

(November 1, 2010 | Vol. 88 Issue 44 | pp. 25-26)

• Ligands Dial In Ring Size
• Varying the ligand in a particular palladium-catalyzed cyclization reaction gives chemists access to four different types of heterocycles
• Atmospheric Nitric Acid Rate Constant Clarified
• The reaction of hydroxyl radicals with nitrogen dioxide to form gaseous nitric acid is critical in atmospheric chemistry because it sequesters the reagents and slows the catalytic cycle
• Pentacenes Exhibit Unsymmetrical Side
• A synthetic strategy that produces previously rare unsymmetrical pentacene derivatives has been developed, broadening the chemical repertoire of this industrially useful class of compounds
• Turning Up The Heat On DNA Methylation
• A simple melting test can detect DNA methylation at the genomic level, a development that could bolster the study of gene expression and epigeneticsr
• Parrot Pigments Preserve Pretty Plumage …
• Parrot feather pigments appear to have properties that promote resistance to bacterial degradation
• … And Red Alga Pigments Stand The Test Of Time
• An unusual class of boron-containing organic pigments, dubbed borolithochromes, is responsible for the pink color of a fossilized Jurassic-period red alga
• Prion Aggregate Size Affects Transmissibility
• In work that could aid understanding of protein-misfolding diseases, researchers have found that the size of prion aggregates affects their ability to induce further aggregation and cause illness
• Gradient Core-Shell Quantum Dots
• Colloidal quantum dots with core-shell structures in which both components feature alloyed gradient compositions have been prepared by researchers in Israel

October 25, 2010

The Un-Rankings

(October 25, 2010 | Vol. 88 Issue 43 | pp. 12-17)

Chemistry graduate programs seek meaning in long-awaited assessment.

Greening Up Process Chemistry (Member Content)

(October 25, 2010 | Vol. 88 Issue 43 | pp. 45-47)

Advances in biocatalysis, taming hazardous reactions help improve pharmaceutical and fine chemicals production.

Brain Glucose, Drop By Drop

(October 25, 2010 | Vol. 88 Issue 43 | pp. 48-49)

Microfluidic device reveals link between glucose and patient outcome in brain injury.

Recycling Red Mud (Member Content)

(October 25, 2010 | Vol. 88 Issue 43 | pp. 50-51)

Researchers seek ways to recycle the alumina refining waste that caused catastrophe in Hungary.

Moon Crater's Icy Character

(October 25, 2010 | Vol. 88 Issue 43 | p. 7)

Astrochemistry: Lunar impactor may have struck a site of previous comet impacts.

Nanodiamond Driver

(October 25, 2010 | Vol. 88 Issue 43 | p. 9)

Hybrid catalyst mediates steam-free dehydrogenation of ethylbenzene to styrene.

Sensing Peroxide Explosives

(October 25, 2010 | Vol. 88 Issue 43 | p. 11)

Antiterrorism: Sensor array detects triacetone triperoxide at part-per-billion levels.

Science & Technology Concentrates (Member Content)

(October 25, 2010 | Vol. 88 Issue 43 | pp. 43-44)

• Steady Fix For Alzheimer's
• Epothilone D could be useful for stabilizing the microtubules critical for transporting molecules in neurons
• Trifluoroselenoacetic Acid Makes Its Debut
• Chemists report the first synthesis of CF₃C(O)SeH, a previously unknown strong acid with synthetic potential
• Plants Make A Big Grab For VOCs
• Tree leaves may take up more volatile organic compounds from the atmosphere than previously recognized
• Luminescent Glow Measures Temperature
• Bimetallic lanthanide-based materials can function as a high-precision nanoscale sensor
• Liquid Crystals Extend Electrophoresis
• Employing a liquid crystalline fluid phase opens up electrophoresis to separating symmetrical or uncharged particles
• Walking Molecule Follows The Light
• Small molecules that "walk" now have a new skill––the ability to controllably change direction when zapped by light
• Better Sampling Captures Ubiquitous Methylsiloxanes
• An improved method measures trace amounts of the pollutant without sample cross-contamination
• Easily Recycled Coupling Catalysts
• A new family of phosphane ligands could help bring down the high cost of palladium-catalyzed coupling reactions

October 18, 2010

Metallocenes Rise Again

(October 18, 2010 | Vol. 88 Issue 42 | pp. 10-16)

The advanced polymer catalysts got off to a slower than expected start, but momentum in the marketplace is now steady.

Handing Down Hope (Member Content)

(October 18, 2010 | Vol. 88 Issue 42 | pp. 28-30)

Through equipment donations, Seeding Labs helps cultivate relationships between scientists in the U.S. and the developing world.

Broadcasting Science

(October 18, 2010 | Vol. 88 Issue 42 | p. 31)

Deepwater Horizon spill shows how the Internet accelerates reporting of the science of disasters.

Anton Supercomputer Proves Its Mettle

(October 18, 2010 | Vol. 88 Issue 42 | p. 5)

Protein Dynamics: Machine simulates millisecond-scale protein motions, but some note system has limitations.

Cystine Imposters Curb Crystallization

(October 18, 2010 | Vol. 88 Issue 42 | p. 7)

Crystal Engineering: Molecular mimics suggest therapeutic strategy for rare kidney disease.

Coupling Hydrazine

(October 18, 2010 | Vol. 88 Issue 42 | p. 8)

Organic Synthesis: Palladium-catalyzed reaction offers new route to heterocycles.

Science & Technology Concentrates (Member Content)

(October 18, 2010 | Vol. 88 Issue 42 | pp. 26-27)

• Smoking Fingerprint
• Of the thousands of molecules released when someone lights up a cigarette, 2,5-dimethylfuran has been deemed the best “smoking gun
• Carbon Dioxide As Earth’s Temperature ‘Control Knob’
• Of all the greenhouse gases in Earth’s atmosphere, including water vapor, carbon dioxide exerts the most control on climate
• Ring Size adjusts Carbene Reactivity
• The first N,Nʹ-diamidocarbene (DAC) with a seven-membered ring has been synthesized by chemists at the University of Texas, Austin
• Organic Aerosols Form Solid Particles
• Atmospheric aerosol particles formed from volatile organic compounds most likely exist as glassy, amorphous solids, rather than as liquid droplets
• Side Chains Insulate Polythiophene Wires
• By sheathing polythiophene with its own cyclic side chains, chemists in Japan have created an insulated molecular wire that’s free from structural defects
• DNA-Based Matrix Tunes Cell Properties
• A new type of DNA-based artificial extracellular matrix permits the tuning of cellular morphology for tissue engineering
• Hyperhalogens Amp Up Electronegativity
• Chemists have synthesized a class of gold-and-boron-based molecules that have ultrahigh electronegativities
• ‘Chiral Fluoride’ Separates Alcohols
• Thanks to the unusual combination of a crown ether moiety and a chiral organocatalyst, chemists in South Korea have developed a simple method for separating enantiomers of silyl-protected secondary alcohols

October 11, 2010

Fighting Friction

(October 11, 2010 | Vol. 88 Issue 41 | pp. 14-17)

In the battle to overcome resistance between surfaces, performance materials improve energy efficiency and help critical components last longer.

Ubiquitins Are Finally United (Member Content)

(October 11, 2010 | Vol. 88 Issue 41 | pp. 36-37)

New synthetic approaches put a long-sought end to ubiquitin proteins' unchained melody.

What's That Stuff? Fix-A-Flat

(October 11, 2010 | Vol. 88 Issue 41 | p. 39)

A combination of liquefied propellant and tire sealant helps stranded motorists.

Nobel Prize In Chemistry

(October 11, 2010 | Vol. 88 Issue 41 | p. 7)

Awards: Three chemists share prize for palladium-catalyzed cross-couplings.

Nobel Prize In Physics

(October 11, 2010 | Vol. 88 Issue 41 | p. 8)

Awards: Andre Geim and Konstantin Novoselov land prize for discovering graphene.

Celebrating Chemistry

(October 11, 2010 | Vol. 88 Issue 41 | p. 8)

National Chemistry Week, slated for Oct. 17-23, looks at the chemistry of entertainment.

Nobel Prize In Physiology Or Medicine

(October 11, 2010 | Vol. 88 Issue 41 | p. 9)

Awards: Robert Edwards gets nod for developing in vitro fertilization.

New Window On Phosphorylation

(October 11, 2010 | Vol. 88 Issue 41 | p. 10)

Protein Chemistry: Structural mimics provide a handle on tough-to-capture modification.

Toxic Spill in Hungary Kills Four

(October 11, 2010 | Vol. 88 Issue 41 | p. 11)

Environment: Breached reservoir sends poisonous waste through villages.

Celebrating Science & Engineering

(October 11, 2010 | Vol. 88 Issue 41 | p. 12)

Science & Society: First national festival aims to better connect the public with science and engineering.

Science & Technology Concentrates (Member Content)

(October 11, 2010 | Vol. 88 Issue 41 | pp. 34-35)

• Two Carbenes Better Than One
• The first N-heterocyclic carbene with two carbene centers, instead of the usual one, has been synthesized
• Laser Deposition Method Lays Down Ionic Liquids
• Study extends controlled-deposition techniques to low-vapor-pressure, hard-to-manipulate materials
• Explosive Carbonyl Diazide Safely Made
• A team of chemists has developed a safe way to prepare and handle OC(N₃)₂, a potentially useful reagent
• Phosphorylation And Acetylation In Action
• NMR technique allows researchers to simultaneously detect posttranslational modifications taking place
• Copper-Nitrosyl Complex Unveiled
• Chemists characterize a key intermediate in the reduction of NO₂– to NO by the enzyme copper nitrite reductase
• Tracking mRNA Particles
• 3-D optical imaging is used to follow mRNA particles inside yeast cells with nanometer-scale precision
• Following The Flow In Microchannels
• Remote-detection MRI and NMR yield detailed information about chemistry and fluid flow within microscopic structures
• Peanut Bouquet Molecules Identified
• Food chemists figure out the subset of molecules emanating from raw and roasted peanuts that make them so enticing

October 4, 2010

Sustainable R&D

(October 4, 2010 | Vol. 88 Issue 40 | pp. 36-37)

The Warner Babcock Institute brings business savvy to green chemistry research.

Green Outreach: The Beyond Benign Foundation

(October 4, 2010 | Vol. 88 Issue 40 | p. 37)

Lab In A Mine (Member Content)

(October 4, 2010 | Vol. 88 Issue 40 | pp. 38-39)

Construction of facility for physics and other experiments in former gold mine might start in 2014.

Long-Awaited Ph.D. Program Rankings Released

(October 4, 2010 | Vol. 88 Issue 40 | p. 5)

Graduate Schools: National Research Council evaluates doctoral programs for first time since 1995.

Boosting Taxol Production

(October 4, 2010 | Vol. 88 Issue 40 | p. 6)

Natural Products: Engineered bacteria churn out cancer drug precursors.

Earth Gets A Doppelganger

(October 4, 2010 | Vol. 88 Issue 40 | p. 6)

Exoplanets: Astronomers discover habitable planet orbiting nearby star.

Switchable Catalysts

(October 4, 2010 | Vol. 88 Issue 40 | p. 8)

Materials Chemistry: Synthetic compounds mimic enzymes' on-off property.

Perturbing A Cancer Reader

(October 4, 2010 | Vol. 88 Issue 40 | p. 8)

Chemical Biology: Blocking a protein that recognizes markers on chromatin shrinks tumors in mice.

Science & Technology Concentrates (Member Content)

(October 4, 2010 | Vol. 88 Issue 40 | pp. 34-35)

• One Mouth Microbe Regulates Another
• Mutanobactin A made by one bacterium inhibits the growth of another microorganism—in people
• Polymer Sustainability Metrics Compared
• Biopolymers rank high for green design, but petroleum-based polyolefins rank higher in overall life-cycle assessments
• Ultrasound makes big Crystals of Mercury Thiolates
• Sonicating liquid mercury-alkanethiol mixtures leads to large, high-quality crystals of electronics chemicals
• Solar Cell Captures Multiple Excitations
• Quantum-dot-based system converts high-energy photons into multiple electrons to boost photovoltaic efficiency
• Free Heme Promotes Severe Sepsis
• Blood's iron-toting compound heme is key to the body's systemic inflammatory response to an infection
• Shifty Manipulation Of Microdroplets
• Microfluidic device allows easy formation, storage, and retrieval of water droplets for biomedical applications
• 'Artificial Leaf' Produces Electricity
• A water-based gel impregnated with photosensitive molecules serves as a new type of biomimetic solar cell
• New Simple CO₂ Sensor
• Analytical Techniques: Easy-to-read chemosensor requires little power and does not pick up signals from other gases

September 27, 2010

Putting DNA In A Bind (Member Content)

(September 27, 2010 | Vol. 88 Issue 39 | pp. 50-53)

ACS Meeting News: Small molecules that interact with DNA are bound to regulate gene expression.

How Foods And Drugs Collide (Member Content)

(September 27, 2010 | Vol. 88 Issue 39 | pp. 55-57)

ACS Meeting News: Interactions between medications, foods, and supplements take many forms.

Tenofovir For The Developing World (Member Content)

(September 27, 2010 | Vol. 88 Issue 39 | pp. 58-59)

ACS Meeting News: Process chemists rework synthesis of anti-HIV drug to lower its cost.

Industry In The Ivory Tower (Member Content)

(September 27, 2010 | Vol. 88 Issue 39 | pp. 60-61)

Ronald Breslow, a lifelong academic, garners the chemical industry's big prize, the Perkin Medal.

Probing the Key Vision Event

(September 27, 2010 | Vol. 88 Issue 39 | p. 11)

Ultrafast Spectroscopy: Rhodopsin isomerization owes speed to conical intersection between electronic states.

Light Controls Surface-Charging

(September 27, 2010 | Vol. 88 Issue 39 | p. 13)

Electrostatics: Method could reveal mechanism of ubiquitous phenomenon behind static cling, copy machines.

More Linda Buck Retractions

(September 27, 2010 | Vol. 88 Issue 39 | p. 13)

Nobelist retracts two more studies on olfaction that could not be reproduced.

Oil Spill's Size Swells

(September 27, 2010 | Vol. 88 Issue 39 | p. 14)

Deepwater Horizon: Magnitude of Gulf accident is far larger than previous estimates.

Assay For Key Ghrelin Enzyme

(September 27, 2010 | Vol. 88 Issue 39 | p. 15)

Click Chemistry: Approach could help researchers find antiobesity drug leads.

Science & Technology Concentrates (Member Content)

(September 27, 2010 | Vol. 88 Issue 39 | pp. 48-50)

• Alkali Metal Aids Catalysis
• The water-gas shift reaction can be catalyzed at lower cost by platinum aided by an alkali-metal promoter
• Silver Nanoparticles Transform In Sewers
• Silver in our cosmetics and clothes can end up as silver sulfide nanoparticles in sewer sludge
• Unnatural Amino Acid Spurs Polymer Growth
• A synthetic amino acid containing a polymerization initiator promotes formation of protein-polymer bioconjugates
• Toxicity Risk Reduced For Isothiazole Drug
• Scientists take advantage of toxicity data to modify an anticancer drug to avoid the toxicity without altering efficacy
• Gut Gas Gives Salmonella A Boost
• The pathogenic bacterium gets energy from tetrathionate produced from gut inflammation that the bacterium causes
• Shorter Route To Strychnine Unveiled
• A surprising SmI2-mediated cascade reaction is at the heart of the shortest route to the poisonous natural product
• X-Ray Imaging Method Boosts Contrast Of Biological Features
• High-resolution 3-D technique resolves nanometer-sized structures with unprecedented clarity
• Low-Cost Phosphite Ligands Improve Metathesis Catalysts
• Phosphite ligands offer advantages over current catalysts for some challenging reactions

September 20, 2010

Raman Heads For The Clinic

(September 20, 2010 | Vol. 88 Issue 38 | pp. 8-12)

Vibrational spectroscopy technique may someday be used to diagnose a variety of diseases.

Drive-By Conservation (Member Content)

(September 20, 2010 | Vol. 88 Issue 38 | pp. 26-28)

Mobile laboratory treks across Europe to study cultural masterpieces.

Monitoring Cellular Metals (Member Content)

(September 20, 2010 | Vol. 88 Issue 38 | pp. 29-30)

ACS Meeting News: Techniques are being developed to probe the location and concentration of essential metal species in cells.

Synthetic Skin Gets A Soft Touch

(September 20, 2010 | Vol. 88 Issue 38 | p. 3)

Materials Science: Pressure sensors give artificial skin a sense of touch.

Boosting Solid-State NMR

(September 20, 2010 | Vol. 88 Issue 38 | p. 6)

Surface Science: Signal-enhancing technique makes NMR a powerful probe of surfaces.

Paper-Thin Batteries

(September 20, 2010 | Vol. 88 Issue 38 | p. 6)

Lithium layers over nanotube films, separated by paper, create ultrathin power source.

Science & Technology Concentrates (Member Content)

(September 20, 2010 | Vol. 88 Issue 38 | pp. 24-25)

• Mass Spec Variability Hinders Biomarker Analysis
• Ions used to identify biomarkers in metabolite profiling can vary from one instrument to the next
• Modified Luciferin Boosts Light Emission
• Replacing a functional group in the firefly molecule pumps up the luminescence intensity
• Nanohorse Hampered By Its Gait
• A "bipedal" molecule does a better job than a "four-legged" molecule moving across a surface
• Microbes Got A Boost From Oil-Leak Propane
• Bacteria feeding off hydrocarbons in the Gulf of Mexico were initially stimulated by a natural-gas appetizer
• Fluorescence Method Detects Stem Cells
• The first fluorescent probe for detecting embryonic and induced pluripotent stem cells has been developed
• Formate Energizes Microbes
• Some species of archaea can survive with only formate providing for their energy needs
• A Hint Of Carbyne
• End-capping strategy paves the way for a potential synthesis of the elusive carbon allotrope
• Graphene-Molecule Hybrid Structures
• Graphene and organic molecules form nanowires via a back-and-forth self-assembly process

September 13, 2010

Nuclear Efficiency (Member Content)

(September 13, 2010 | Vol. 88 Issue 37 | pp. 29-31)

With new fuel formulations, reactors could extract more energy, reduce hazardous waste.

Full-Steam Ahead For Organometallics (Member Content)

(September 13, 2010 | Vol. 88 Issue 37 | pp. 33-35)

ACS Meeting News: Chemists pay tribute to a respected editor and look to the future of the field.

Frogs Inspire New Antimicrobials (Member Content)

(September 13, 2010 | Vol. 88 Issue 37 | pp. 36-37)

ACS Meeeting News: Amino acid substitutions boost natural peptides' germ-killing abilities and reduce side effects.

Jordan Conference Stirs Controversy

(September 13, 2010 | Vol. 88 Issue 37 | p. 38)

International: Nobel Laureates suspect sinister motives in absence of Israeli scientists; many others disagree.

Ion-Initiated Cross-Talk

(September 13, 2010 | Vol. 88 Issue 37 | p. 5)

Supramolecular Chemistry: Electron transfer in complex begins with ionic interactions.

Melanoma Drug's Structure Revealed

(September 13, 2010 | Vol. 88 Issue 37 | p. 7)

Drug Development: Promising skin cancer therapy targets a rogue kinase.

A Bleak View For Curbing CO₂

(September 13, 2010 | Vol. 88 Issue 37 | p. 8)

Environment: Breaking the world's fossil-fuel addiction will be difficult at best, study suggests.

Science & Technology Concentrates (Member Content)

(September 13, 2010 | Vol. 88 Issue 37 | pp. 26-27)

• Spying On Fleeting Proteins
• NMR-based method allows scientists to catch a rare glimpse of protein-folding intermediates
• Electrons Zap Clean Nanotube Sensors
• Simply applying an electric current to the tubes quickly and effectively jolts off adsorbed molecules
• Flash Of Phosphorus Chemistry Innovation
• Chlorine-free strategy for making organophosphorus compounds takes advantage of UV light
• Silicon Nanowire Detects Explosives
• Ultrasensitive arrays of silane-functionalized nanowires outsniff dogs in selectively detecting TNT
• Genetic Risk Factor Found For Migraines
• Study results should add impetus to the development of treatments that inhibit glutamate signaling
• Going The Distance
• Structural Biology: Switchable fluorescence technique measures multiple distances in single molecules.
• Universal Cis-Trans Aziridinations
• Swapping functional groups switches an aziridination reaction's diastereoselectivity from cis to trans
• 'Nindigo': A New Ligand Architecture
• Treating the dye molecule indigo with substituted anilines leads to two diketimine binding sites in one ligand

September 6, 2010

When Science Went International

(September 6, 2010 | Vol. 88 Issue 36 | pp. 60-62)

Looking back 150 years at the conference that led to the assembly of the periodic table.

Behind A Metal Makeover

(September 6, 2010 | Vol. 88 Issue 36 | pp. 63-64)

ACS Meeting News: To ensure their survival, pathogenic bacteria turn to manganese, not iron, when making an essential metalloenzyme.

Transition State Captured By Force (Member Content)

(September 6, 2010 | Vol. 88 Issue 36 | pp. 65-66)

Stretching a polymer changes the way it isomerizes.

What's That Stuff? Road Markings

(September 6, 2010 | Vol. 88 Issue 36 | p. 67)

Pigments, polymers, and reflective spheres help keep you safe on the road.

Covering Up For A Clear View

(September 6, 2010 | Vol. 88 Issue 36 | p. 11)

Surface Science: A blanket of graphene helps reveal the structure of water lying underneath.

Technique Combo Beats NMR Solo

(September 6, 2010 | Vol. 88 Issue 36 | p. 12)

Structural Biology: Combined strategy yields largest-ever solution structures.

New Hope For Malaria

(September 6, 2010 | Vol. 88 Issue 36 | p. 13)

Compound cures mice in one dose, works by a mechanism different from that of existing drugs.

Probing Individual Chemical Events

(September 6, 2010 | Vol. 88 Issue 36 | pp. 14)

Imaging: Method tracks single-molecule reactions spatially and temporally.

Nanopore-Based Screening

(September 6, 2010 | Vol. 88 Issue 36 | pp. 14)

DNA Analysis: Method detects single molecules passing through holes in graphene.

Academies Review Climate Panel

(September 6, 2010 | Vol. 88 Issue 36 | p. 15)

Climate Change: UN panel needs new leadership, says coalition of national science academies.

Science & Technology Concentrates (Member Content)

(September 6, 2010 | Vol. 88 Issue 36 | pp. 58-59)

• H₂ At The Tip Of STM Boosts Resolution
• STM resolution of complex organic molecules can be greatly enhanced by modifying the tip
• Binding Site Broadens Prospects For Prostate-Cancer Drugs
• Scientists have found a new binding site in prostate-specific membrane antigen, a cancer-cell-surface receptor
• Calculated NMR Approach Improves Isomer Identification
• A probability measure works unusually well in matching calculated and experimental spectra
• Solvation Shell Helps Track Charge Transfer
• Researchers report monitoring ultrafast charge transfer in a dye molecule via the IR spectrum of its solvent shell
• Altruistic Bacteria Thwart Antibiotic
• Highly resistant bacteria produce extra indole to help their less resistant siblings survive a norfloxacin assault
• Nature's Route To Sunscreen Revealed
• Cyanobacteria are found to use a multienzyme pathway to build small molecules for sun protection
• Petal Shapes From A β–Peptide
• A research team has identified a β–peptide that self-assembles to form unprecedented 3-D structures
• Another Target For Alzheimer's Drugs
• A molecular probe fashioned from a cancer drug that inhibits amyloid-β helps uncover γ-secretase activating protein

August 30, 2010

Grassroots Grants (Member Content)

(August 30, 2010 | Vol. 88 Issue 35 | pp. 26-27)

Three nonprofits want to fund early-stage research with help from the masses.

Breaking Carbon's Tetrahedral Mold (Member Content)

(August 30, 2010 | Vol. 88 Issue 35 | pp. 28-29)

Chemists' fascination with square-planar carbon compounds continues.

Judge Halts Stem Cell Research

(August 30, 2010 | Vol. 88 Issue 35 | p. 4)

Injunction: Federal funding for all human embryonic stem cell research must cease.

Making Edible Nanostructures

(August 30, 2010 | Vol. 88 Issue 35 | p. 6)

ACS Meeting News: Food-grade starting materials yield new metal-organic framework compounds.

Silver Bullet For Fluorinations

(August 30, 2010 | Vol. 88 Issue 35 | p. 6)

ACS Meeting News: Late-stage cross-coupling may open route to radiotracers.

A Head-Shaking Sensor

(August 30, 2010 | Vol. 88 Issue 35 | p. 7)

Bioengineering: Chemical detection linked to live cells and robotic mannequin.

Red Wine Mimics Defended

(August 30, 2010 | Vol. 88 Issue 35 | p. 8)

ACS Meeting News: Sirtris says controversial antiaging compounds act at an allosteric site.

Science & Technology Concentrates (Member Content)

(August 30, 2010 | Vol. 88 Issue 35 | pp. 24-25)

• Oysters Use Chemistry To Stick Together
• ACS Meeting News: Distinctive adhesive is helping scientists understand marine biology and providing a model for synthetic mimics.
• SERS Hot Spots Probed
• ACS Meeting News: Imaging shows larger-than-expected SERS-analyzable spots on nanoparticles.
• Self-Cleaning Solar Panels
• ACS Meeting News: Collected dust particles that block sunlight can be shaken off with a jolt of electricity.
• Crystallite Seeds Shape Up Micelles
• ACS Meeting News: Templated self-assembly process produces highly uniform cylindrical nanomaterials.
• A New Route To Germ-Killing Photons
• ACS Meeting News: Lanthanide nanomaterials convert visible light into disinfecting ultraviolet light.
• Built-In Timers For Paper Devices
• ACS Meeting News: Wax is used to time paper-based microfluidic assays.
• Bacteria Create Electrical Spikes
• ACS Meeting News: Microbe behavior could be akin to neuron firing.
• New Cloak May Suit Many Drugs
• ACS Meeting News: Novel prodrug strategy improves an experimental HIV pill

August 23, 2010

The Power Of Plastic

(August 23, 2010 | Vol. 88 Issue 34 | pp. 34-37)

Polymer- and organic-molecule-based solar cells show promise as low-cost power generators.

Texas Tech Lessons (Member Content)

(August 23, 2010 | Vol. 88 Issue 34 | pp. 34-37)

Explosion highlights need to improve safety culture at university, initiates government oversight.

Golden Anniversary (Member Content)

(August 23, 2010 | Vol. 88 Issue 34 | pp. 38-40)

Royce murray celebrates 50 years at the University of North Carolina.

Uncovering A New Chlorophyll

(August 23, 2010 | Vol. 88 Issue 34 | p. 7)

Natural Products Chemistry: Researchers find a fifth type of the ubiquitous pigment in coastal Australia.

Antidepressant's Unusual Speed Explained

(August 23, 2010 | Vol. 88 Issue 34 | p. 8)

Neuroscience: Ketamine, which can overcome depression in hours, stimulates rapid synapse formation.

Gulf Oil Plume Tracked

(August 23, 2010 | Vol. 88 Issue 34 | p. 11)

Oil Spill: First journal report to characterize deep-sea oil plume.

Science & Technology Concentrates (Member Content)

(August 23, 2010 | Vol. 88 Issue 34 | pp. 40-41)

• Single-Crystal Heterojunctions
• Vapor-deposition method yields the first single crystalline semiconductor p-n junction
• Hydroxyurea's Revised Sickle Cell Role
• Drug stimulates the production of nitric oxide in red blood cells, a finding that could improve treatments
• Nanofiber Scaffolds As Brain Bandages
• Aligned nanofibers are an improved substrate for making dura mater grafts to aid healing after neurosurgery
• Herbal Remedy Counters Chemo's Side Effects
• A traditional Chinese medicine helps alleviate the gastrointestinal side effects of a colon cancer drug
• Megaenzyme Crystal Structure Unveiled
• The X-ray structure of a 750-kilodalton bacterial carboxylase should provide clues about human diseases
• Diiron Enzymes Spark Hydroxylations
• Diiron monooxygenases join monoiron enzymes in the ability to perform β-hydroxylation of amino acids
• Lithium Car Battery's Footprint Assessed
• Electric vehicles win out over their gasoline-fueled counterparts when it comes to environmental performance
• Chemogenetic Natural Product Analogs
• Combining biosynthetic and chemical synthesis steps provides an easy way to diversify natural products

August 16, 2010

Exposing The Exposome (Member Content)

(August 16, 2010 | Vol. 88 Issue 33 | pp. 42-44)

Individuals' records of environmental exposures may yield clues to the causes of disease.

Safeguarding NASA's Moon Rocks (Member Content)

(August 16, 2010 | Vol. 88 Issue 33 | pp. 46-47)

Lab at Johnson Space Center preserves 40-year-old lunar samples for study.

A Wire For Spying On Cells

(August 16, 2010 | Vol. 88 Issue 33 | p. 9)

Nanotechnology: Tiny bioprobe features a field-effect transistor built from a kinked silicon nanowire.

Reviving An Antibiotic Target

(August 16, 2010 | Vol. 88 Issue 33 | p. 11)

Structural Biology: Novel binding interaction could lead to new class of antibacterial drugs.

Directing Materials Research

(August 16, 2010 | Vol. 88 Issue 33 | p. 11)

Engineering professor Ian M. Robertson will head the Materials Research Division at NSF.

Science & Technology Concentrates (Member Content)

(August 16, 2010 | Vol. 88 Issue 33 | pp. 40-41)

• Peptide Rounds Up Amyloid-β
• Potential Alzheimer's drug renders toxic amyloid-β oligomers into innocuous clumps.
• Fullerene-like Boron Analog Reevaluated
• B80 is likely to have an unsymmetrical core-shell structure, not a symmetrical hollow cage structure as previously thought.
• Isotopes Help Home In On Ancient Rock
• Arctic region lava samples provide an unprecedented view of nascent Earth's geochemical evolution.
• Computations Clarify Oxidation Pathways
• Radical oxidation of vinyl alcohol follows different routes in atmospheric and combustion processes.
• Drug Design Leads To Desired Enzyme Inhibitors
• Non-bisphosphonate inhibitors of farnesyl pyrophosphate synthase could lead to cancer treatments.
• SANE Approach To Soft Lithography
• Method offers an easy way to make many different patterns starting with a single master pattern.
• Role Of Iron Regulatory Proteins Ironed Out
• On top of other functions, IRPs make it possible for cell mitochondria to maintain proper iron balance.
• Scaffolding Ligand Directs Quaternary Carbon Synthesis
• A bifunctional amine-phosphine ligand is proving to be a versatile directing group for organic syntheses.

August 9, 2010

Microbes To The Rescue

(August 9, 2010 | Vol. 88 Issue 32 | pp. 32-33)

The fate of spilled oil in the Gulf rests with the hydrocarbon-digesting microorganisms colonizing underwater plumes.

What's That Stuff? Trick Candles

(August 9, 2010 | Vol. 88 Issue 32 | p. 34)

A little magnesium dust ignites surprise at birthday parties.

Dispersants' Effects Debated

(August 9, 2010 | Vol. 88 Issue 32 | p. 5)

Gulf Oil Spill: Much needs to be learned about oil treatments' toxicity, scientists say.

Stem Cell Multiplier

(August 9, 2010 | Vol. 88 Issue 32 | p. 7)

Medicinal Chemistry: Small molecule spurs the proliferation of blood stem cells.

A Radical Way To Make Phosphines

(August 9, 2010 | Vol. 88 Issue 32 | p. 8)

Organic Synthesis: Chlorine-free procedure could lead to a green industrial process.

Gulf Of Mexico Dead Zone

(August 9, 2010 | Vol. 88 Issue 32 | p. 9)

Annual measurement reveals record hypoxic zone, but not necessarily related to the oil spill.

Science & Technology Concentrates (Member Content)

(August 9, 2010 | Vol. 88 Issue 32 | pp. 34-35)

• Quantum Dot Mystery Resolved
• A secondary phosphine in the starting material seems to be key to forming PbSe nanomaterials
• Silicon And Carbon Try To Triple Up
• A putative Si≡C bond has been observed in an isolable compound for the first time
• Inhibitor Targets Glycoprotein Of Unknown Structure
• A fragment-based approach homes in on an inhibitor, even though the corresponding protein's structure is unavailable to help
• Diels-Alder Building Block Debuts
• Cyclobutenone's ring strain brings more cycloaddition possibilities to this classic reaction
• Neurons Clear Their Own Path
• Scientists discover how neurons secrete a protein to help push through brain tissue to reach their final destinations
• Estrogen Throws Cold Water On Fish Courtship
• Water Pollution: When exposed to estrogen early in their life, female fish give dominant males the brush-off
• Nitrogenase Makes Hydrocarbons
• Vanadium nitrogenase, which usually converts N₂ to NH₃, can also convert CO to ethylene, ethane, and propane
• Chlorine Record Suggests The Moon Was Always Dry
• A study of chlorine isotopes in moon rocks indicates that Earth's satellite is devoid of water, contradicting other recent studies

August 2, 2010

Recipes For Limb Renewal

(August 2, 2010 | Vol. 88 Issue 31 | pp. 40-44)

Salamanders and other creatures that regrow lost body parts provide clues for ways to regenerate human limbs.

Copying An Original

(August 2, 2010 | Vol. 88 Issue 31 | p. 42)

Faithful replication of a lost limb demands tight process control.

Chemistry At Peking University Turns 100

(August 2, 2010 | Vol. 88 Issue 31 | pp. 46-49)

University's chemistry college, the oldest in China, has ambitious plans to promote innovative work, recruit top young talent.

Power From Motion (Member Content)

(August 2, 2010 | Vol. 88 Issue 31 | pp. 50-51)

Nanogenerators exploit mechanical processes inside and outside the body to power electronic devices.

Plumes Finger Oil Spill

(August 2, 2010 | Vol. 88 Issue 31 | p. 12)

Geochemistry: BP leak is behind undersea oil plumes, isotopic analyses confirm.

U.S. Wins Gold

(August 2, 2010 | Vol. 88 Issue 31 | p. 14)

Chemistry Olympiad: Team earns two gold medals, a silver, and a bronze; China takes first place.

Counting Proteins

(August 2, 2010 | Vol. 88 Issue 31 | p. 15)

Proteomics: Single-molecule methods quantify bacterium's proteome.

Breaking Up Is Hard To Do

(August 2, 2010 | Vol. 88 Issue 31 | p. 15)

Femtosecond Science: Technique tracks structure, electron dynamics during reactions.

Science & Technology Concentrates (Member Content)

(August 2, 2010 | Vol. 88 Issue 31 | pp. 34-35)

• Shaking Paves Way To Clean DNA
• Nucleic Acid Chemistry: Method purifies by catching desired product in a gel.
• Solar Photo-Thermal Electrochemistry Demonstrated
• A new process uses the full power of the sun--both visible light and thermal heating--to drive electrochemical reactions.
• Crystalline Sheets, Courtesy Of A Cosolvent
• Adding a chloroalkane to the preparation of PbS nanocrystals shifts the crystal shape from spheres to ultrathin sheets.
• Mass Tags Quantify Glycosylation
• Researchers have found a way to determine the stoichiometry of O-GlcNAc glycosylation in proteins.
• MicroRNAs' Role In Neurodegeneration
• For the first time, noncoding pieces of RNA have been shown to be involve in a neurological disease.
• Pesticide Activity Extends To The Brain
• Organophosphorus and thiocarbamate pesticides have secondary effects in the brain, a study in mice reveals.
• Atomic Images May Aid Structure Elucidation
• Atomic-resolution scanning probe microscopy can help pin down tricky structures of planar organic molecules.
• Details Emerge On Alkane Biosynthesis
• LS9 scientists identify the genes and enzymes that certain bacteria use to convert fatty acids to alkanes and alkenes.

July 26, 2010

Carbon Dioxide's Unsettled Future (Member Content)

(July 26, 2010 | Vol. 88 Issue 30 | pp. 36-38)

Technologies to reel in greenhouse gas emissions abound, but can't move forward without policy actions.

Pain Relief From Snail Spit

(July 26, 2010 | Vol. 88 Issue 30 | pp. 39-40)

Scientists engineer an orally active conotoxin.

In Gold (And Palladium) We Trust (Member Content)

(July 26, 2010 | Vol. 88 Issue 30 | p. 41)

An impurity makes gold-mediated couplings both beautiful and complicated.

One 'Mona Lisa' Mystery Solved

(July 26, 2010 | Vol. 88 Issue 30 | p. 42)

Chemistry And Art: Da Vinci achieved his amazing shadowing by using many strokes of pigmented glaze.

Metalloproteins' Ranks Swell

(July 26, 2010 | Vol. 88 Issue 30 | p. 7)

Bioinorganic Chemistry: Metal-containing proteins more diverse than thought.

Sugar Derivative Solidifies Oil

(July 26, 2010 | Vol. 88 Issue 30 | p. 8)

Materials Chemistry: Gelation process could turn spilled oil into skimmable fat for easy cleanup.

Fullerenes Found In Space

(July 26, 2010 | Vol. 88 Issue 30 | p. 8)

Astrochemistry: Astronomers detect C₆₀ and C₇₀ in dying star.

Fresh Air For Avandia

(July 26, 2010 | Vol. 88 Issue 30 | p. 11)

Drug Discovery: New diabetes drug insights may revive research efforts.

Science & Technology Concentrates (Member Content)

(July 26, 2010 | Vol. 88 Issue 30 | pp. 34-35)

• Making The Most Of Champagne's CO₂
• Champagne's serving temperature and the way in which it's poured make all the difference in preserving its delightful properties.
• Downsizing The Gulf Of Mexico's Dead Zone
• New model suggests larger cuts in nitrogen pollution needed to shrink the Gulf's dead zone.
• Laser-Carbon Combo Opens Cells
• Carbon black nanoparticles activated by femtosecond laser pulses deliver molecules across cell membranes.
• Deck Stains Seal In Contaminants
• A semitransparent penetrating stain might prevent the metal and other inorganic preservatives from escaping from treated wood.
• Cage Keeps C₆₀ Captive In The Solid State
• Molecular cage captures fullerene guests, even in the absence of solvent.
• S_N2 On A Tertiary Carbon
• Some tertiary carbons can undergo bimolecular nucleophilic substitutions after all.
• Fuel-Cell Catalysts Tolerate CO
• Nanoparticulate platinum catalyst that resists carbon monoxide poisoning could lead to longer-lasting fuel cells.
• Graphite Oxide's Flammability Explained
• A common contaminant in graphite oxide renders the material highly flammable.

July 19, 2010

Custom-Made Cells (Member Content)

(July 19, 2010 | Vol. 88 Issue 29 | pp. 34-36)

Synthetic biologists use opposing methods to make microbes with tailored functions.

Supplementing Knowledge

(July 19, 2010 | Vol. 88 Issue 29 | pp. 38-39)

Researchers seek to understand safety of botanical dietary supplements.

Build Your Own Enzyme

(July 19, 2010 | Vol. 88 Issue 29 | p. 5)

Biochemistry: Scientists create the first intermolecular Diels-Alderase.

Moving Forward On Algal Biofuels

(July 19, 2010 | Vol. 88 Issue 29 | p. 6)

Alternative Energy: ExxonMobil, Synthetic Genomics facility will help optimize algal fuel production.

Another Force To Stabilize Proteins

(July 19, 2010 | Vol. 88 Issue 29 | p. 7)

Structural Biology: Unappreciated interaction is widespread, research shows.

Catalysis By Graphene Oxide

(July 19, 2010 | Vol. 88 Issue 29 | p. 8)

Graphene intermediate makes ketones and aldehydes from alcohols, alkynes, and olefins.

Science & Technology Concentrates (Member Content)

(July 19, 2010 | Vol. 88 Issue 29 | pp. 32-33)

• Sensing Volatiles In Color
• A gold-dicopper complex shifts its luminescence emission wavelength when exposed to VOCs.
• Dioxin Levels Plummet
• A long-term study of dioxin levels in the environment points to significant reductions during the 1990s.
• Nanostructures Form Like Polymers
• Novel nanorod self-assembly process resembles step-growth polymerization.
• Thiols Drive Mercury Photodegradation
• Chloride outcompetes organic thiols in seawater, allowing methylmercury to bioaccumulate in seafood.
• Mapping Eye Membranes
• A better understanding of the morphology of a membrane in the eye could lead to better surgical tools.

July 12, 2010

Assessing Aerosols In The Air (Member Content)

(July 12, 2010 | Vol. 88 Issue 28 | pp. 32-34)

Researchers delve into the unknowns of airborne particulates that affect health and climate.

Storm In A Teacup (Member Content)

(July 12, 2010 | Vol. 88 Issue 28 | pp. 35-36)

Water's surface is different from the bulk solution, but how remains a tangled question.

Restoring Neuron Formation (Member Content)

(July 12, 2010 | Vol. 88 Issue 28 | p. 6)

Neuroscience: In rodents, aminopropylcarbazole also helps neurons survive.

Sizing The Proton (Member Content)

(July 12, 2010 | Vol. 88 Issue 28 | p. 9)

Fundamentals: Latest data reveal proton is smaller than believed.

A Boron Cluster-Go-Round (Member Content)

(July 12, 2010 | Vol. 88 Issue 28 | p. 9)

Chemical Bonding: Fluxional behavior in B₁₉^- cluster suggests rotating concentric rings.

Science & Technology Concentrates (Member Content)

(July 12, 2010 | Vol. 88 Issue 28 | p. 31)

• Sensing Volatiles In Color
• A gold-dicopper complex shifts its luminescence emission wavelength when exposed to VOCs.
• Dioxin Levels Plummet
• A long-term study of dioxin levels in the environment points to significant reductions during the 1990s.
• Nanostructures Form Like Polymers
• Novel nanorod self-assembly process resembles step-growth polymerization.
• Thiols Drive Mercury Photodegradation
• Chloride outcompetes organic thiols in seawater, allowing methylmercury to bioaccumulate in seafood.
• Mapping Eye Membranes
• A better understanding of the morphology of a membrane in the eye could lead to better surgical tools.

July 5, 2010

Fuel From The Sun (Member Content)

(July 5, 2010 | Vol. 88 Issue 27 | pp. 26-28)

Cobalt water-oxidation catalysts benefit from federal initiatives to harness solar power to make fuel.

Amyloid's Functions Expand (Member Content)

(July 5, 2010 | Vol. 88 Issue 27 | pp. 29-30)

Molecule that is linked to Alzheimer's might do more than just cause disease.

Big Graphene

(July 5, 2010 | Vol. 88 Issue 27 | p. 31)

New methods yield industrial-sized sheets of ultrathin carbon.

Chemical Aerobics (Member Content)

(July 5, 2010 | Vol. 88 Issue 27 | p. 32)

Kilogram-scale O₂ oxidations safely carried out in a flow reactor.

Pores Galore

(July 5, 2010 | Vol. 88 Issue 27 | p. 31)

Materials: Lengthening organic section of hybrid materials gives compounds with record-breaking properties.

Carboxylation Made Simple

(July 5, 2010 | Vol. 88 Issue 27 | p. 7)

Green Chemistry: Method directly adds CO2 to aromatic C-H bonds.

Targeting Disease

(July 5, 2010 | Vol. 88 Issue 27 | p. 8)

Drug Discovery: Natural products may not be the best place to look for small molecules to treat human ailments.

Science & Technology Concentrates (Member Content)

(July 5, 2010 | Vol. 88 Issue 27 | pp. 24-25)

• Expert Judgments On Climate
• Survey of climate scientists provides insights not readily revealed by climate models.
• NO^2- Created
• The periodic table has once again yielded a new form of a diatomic molecule.
• Probing The Molecular Origins Of Mutagenicity
• Environmental Pollutants: Researchers determine why two closely related airborne pollutants harbor divergent genotoxicity.
• New Nucleoside’s Hangouts Revealed
• Isotope-labeling experiment tracks 5-hydroxymethylcytosine partitioning in the brain.
• Dalesconols Built Via Cascade Reaction
• Judicious use of protecting groups and a clever cascade sequence lead to immunosuppressant natural products.
• New Test For Bromate Additive In Foods
• A mass spec method quickly detects trace amounts of the controversial food additive.
• Sharpening Up Protein NMR
• Spectroscopy: Techniques borrowed from solid-state NMR sharpen proteins' broadened spectral lines.
• Different Amide Biosynthesis Route
• Biosynthesis: ATP-independent pathway could be used to tailor natural products for use as drugs.

June 28, 2010

The Value Of CO₂(Member Content)

(June 28, 2010 | Vol. 88 Issue 26 | pp. 40-41)

Where some see pollution, Andrew Bocarsly sees products.

Green For Eternity

(June 28, 2010 | Vol. 88 Issue 26 | pp. 41-42)

http://pubs.acs.org/cen/science/88/8826sci2.html.

C&EN Talks With John W. Huffman(Member Content)

(June 28, 2010 | Vol. 88 Issue 26 | p. 43)

Organic chemist invented a compound in 1995 that is now at the center of a controversy brewing over synthetic marijuana.

2010 Green Chemistry Awards

(June 28, 2010 | Vol. 88 Issue 26 | p. 9)

Honors: Presidential challenge awards recognize innovations that promote sustainability.

Nanostructure Dynamics

(June 28, 2010 | Vol. 88 Issue 26 | p. 11)

Imaging: time-resolved electron tomography provides 3-D views on ultrafast timescale.

New Route To Amide Formation

(June 28, 2010 | Vol. 88 Issue 26 | p. 13)

Organic Synthesis: Unusual reaction has reactive species with reversed polarities.

Science & Technology Concentrates (Member Content)

(June 28, 2010 | Vol. 88 Issue 26 | pp. 38-39)

• Lung On A Chip
• Lung-mimicking device could replace lung cell culture and animal models in drug development and toxicology testing.
• Children’s Blood Has High Levels Of PBDEs
• Kids’ levels of the fire retardants are higher than their mothers’.
• Tweaks Improve Fluorescence Imaging
• Convex lens and a coverslip improve rejection of background fluorescence and increase the achievable observation time.
• Versatile Catalyst Delivers CF₃ Groups
• Palladium-mediated method adds influential moiety to a variety of molecules.
• Lithium Cation Isolated Within Fullerene
• Stabilized crystal structure could find use in electronics applications.
• Mechanism Of Suzuki-Miyaura Coupling Revealed
• Surprising findings could help researchers optimize coupling reactions.
• Crystal Growth In Retrospect
• New technique back tracks crystal’s life when in situ methods aren’t workable.
• Electron Emission Delay Is Clue To Dynamics
• Laser experiments reveal 20 attosecond difference between an electron’s ejection time from the 2p orbital versus the 2s orbital.

June 21, 2010

High-Res Mass Spec

(June 21, 2010 | Vol. 88 Issue 25 | pp. 10-15)

Mass spectrometry users have more choices for high resolving power, from conventional ion cyclotron resonance to newer time of flight.

Cancer Prevention, Naturally

(June 21, 2010 | Vol. 88 Issue 25 | pp. 28-29)

The difficult search for cancer-preventing natural products takes several paths.

Human Genome Sequence Milestone(Member Content)

(June 21, 2010 | Vol. 88 Issue 25 | pp. 30-31)

Health care improvements come into focus as human sequence marks its 10th year.

Better Route To Hard-To-Get Isomers(Member Content)

(June 21, 2010 | Vol. 88 Issue 25 | p. 32)

Peptidic catalyst yields access to chiral biaryl compounds.

Zewail Is Named 2011 Priestley Medalist

(June 21, 2010 | Vol. 88 Issue 25 | p. 5)

Nobel Laureate honored for development of ultrafast probe methods in chemistry, biology, and materials science.

Antibodies Aid Nerve Repair

(June 21, 2010 | Vol. 88 Issue 25 | p. 6)

Neuroscience: Lack of antibodies inhibits clearance of damaged tissue.

Fiber Bundles Line Up

(June 21, 2010 | Vol. 88 Issue 25 | p. 7)

Materials Science: Gel-like 'noodle' material could act as cell scaffolds.

The Butterfly Effect

(June 21, 2010 | Vol. 88 Issue 25 | p. 8)

Nanoscience: Gyroid nanostructures give butterflies their glimmer.

Trojan Horse For B-Cell Lymphoma

(June 21, 2010 | Vol. 88 Issue 25 | p. 9)

Sugar Chemistry: Chemical synthesis yields agents that target cancer cells.

Science & Technology Concentrates (Member Content)

(June 21, 2010 | Vol. 88 Issue 25 | pp. 26-27)

• Mélange Of Volatiles Distinguish Brandies
• French researchers tease out the chemical “je ne sais quoi” that characterizes apple, plum, and grape brandies.
• Dating Pharaohs
• Conservation Science: Radiocarbon chronology of ancient Egypt is best to date.
• Molecular Machines Spotted On The Move
• Northwestern’s J. Fraser Stoddart and coworkers report the first direct observation of the nanoscale devices in action.
• Modified Gold Particles Serve As Chiral Adsorbents
• Chiral molecules attached to gold serve as an enantioselective separation medium for other types of chiral molecules.
• The Moon Is ‘Wetter’ Than First Believed
• Geologists use hydroxyl groups in moon rock minerals to extrapolate the amount of water once on the lunar surface.
• Cagey Arene Cleavage
• Bis-carborane and ruthenium team up to facilitate difficult room-temperature aromatic C–C bond scission.
• Nanowires Now Deliver
• Gold nanowires precisely manipulated by electric fields deliver a cytokine to targeted cells
• Radical Start For Iron-Sulfur Enzyme
• Novel protein’s 4Fe-4S cluster generates an unusual reactive species to make a modified amino acid.

June 14, 2010

Crowd-Sourced Chemistry

(June 14, 2010 | Vol. 88 Issue 24 | p. 24)

Scientists Use Social Networking To Study Spill.

Speeding Up Separations(Member Content)

(June 14, 2010 | Vol. 88 Issue 24 | pp. 40-44)

Ultra-high-pressure liquid chromatography improves separations and cuts run times by as much as 90%.

New Personnel At Science Foundation

(June 14, 2010 | Vol. 88 Issue 24 | p. 9)

Appointments: MIT's Subra Suresh nominated to lead agency; new Chemistry Division head named.

Nature Publishing May Face Boycott

(June 14, 2010 | Vol. 88 Issue 24 | p. 10)

Publishing: University of California libraries decry journal price hikes.

Iodine Catalysis Goes Green

(June 14, 2010 | Vol. 88 Issue 24 | p. 11)

Synthetic Chemistry: Oxidative cyclization route to chiral drug scaffolds is metal-free.

Nanoreduction Of Graphene Oxide

(June 14, 2010 | Vol. 88 Issue 24 | p. 12)

Materials: Scanning probe method patterns insulator with conducting features.

Catalyst Goes Viral

(June 14, 2010 | Vol. 88 Issue 24 | p. 13)

Nanotechnology: Material grown on a virus template performs better than catalysts grown conventionally.

Strike At University of Puerto Rico Impacts Research

(June 14, 2010 | Vol. 88 Issue 24 | p. 13)

Academe: Despite disruptions, chemistry faculty and students continue working.

Science & Technology Concentrates (Member Content)

(June 14, 2010 | Vol. 88 Issue 24 | pp. 38-39)

• Ultrasensitive Crystal Probe
• Optical method detects early onset of nucleation and crystallization of chiral compounds
• Stretching Alters Magnetics
• Cobalt complex's electron flow is disrupted when the square-shaped molecule is pulled into a rectangle
• Brain Helps Control Cholesterol
• Compound's circulation in blood isn't limited to dietary intake and liver production
• Membrane Proteins Yield To Hydrogen Exchange MS
• Analytical method provides a way to study the membrane proteins' conformations in nativelike conditions
• Polyketide Synthases Don't Determine Enediyne Ring Size
• Enzyme systems all generate the same simple linear heptaene intermediate
• Drugmakers Wash Painkillers Down The Drain
• Water Pollutants: Sewage treatment plants that serve drugmakers release pharmaceuticals at high concentrations
• Electronic Hint For Life's Origins
• Orbital overlap explains a counterintuitive step in a ribonucleotide synthesis feasible on an early Earth
• Key Anti-HIV Antibody Analyzed
• Structure revives hopes for an effective AIDS vaccine

June 7, 2010

Enzyme's Metal Cluster Is Nailed(Member Content)

(June 7, 2010 | Vol. 88 Issue 23 | pp. 39-40)

Definitive solution of the structure of an enzyme in isoprenoid biosynthesis could lead to new antibiotics.

Palladium-Mediated Insertive Behavior(Member Content)

(June 7, 2010 | Vol. 88 Issue 23 | p. 41)

Studies pin down key intermediates in versatile migratory alkene insertion reactions.

Imaging Single Atoms In Zeolites

(June 7, 2010 | Vol. 88 Issue 23 | p. 42)

Materials: Microscopy method reveals positions of catalytic metals anchored inside pores.

Mother Nature's Tenuous Respite(Member Content)

(June 7, 2010 | Vol. 88 Issue 23 | p. 43)

Insights: Forty years of environmental protection is showing some benefits.

Metabolites Turn On Pathogen's Virulence

(June 7, 2010 | Vol. 88 Issue 23 | p. 10)

Natural Products: Staph produces molecules that help it colonize humans.

Catalysis In Crystals

(June 7, 2010 | Vol. 88 Issue 23 | p. 11)

Inorganic chemistry: Single crystals of iridium complex can exchange ligands and hydrogenate ethylene.

Science & Technology Concentrates (Member Content)

(June 7, 2010 | Vol. 88 Issue 23 | pp. 37-38)

• Needling Adenosine
• Acupuncture appears to stimulate release of the natural painkilling compound.
• Clay Layers Help Fabrics Fight Flames
• A polymer-montmorillonite layered composite imparts flame resistance to clothing and other materials.
• Imaging Enzyme Replacement Therapy
• PET imaging is used for the first time to monitor therapeutic enzyme distribution and lifetime.
• New Molecular Way To Combat The Flu
• Microbiologists uncover a new protein target and a small molecule that inhibits the protein.
• Atmospheric Trioxy Radical Idea Banished
• Transient fusing of O₂ and ·OH to form ·HO₃ doesn’t seem to be important in atmospheric chemistry.
• Glowing Proteins On The Spot
• Mutant bacterial enzyme labels proteins site-specifically inside live cells.
• Tagging Peptides Enables C-Terminomics
• A strategy is unveiled for easily finding proteins activated by cleavage at the C-terminus, rather than the N-terminus.
• Waste Plastics Become Functional Carbon Microspheres
• Plastic bags are “upcycled” into a material that could find new life printer toner, tires, and more.

May 31, 2010

Finding Solutions

(May 31, 2010 | Vol. 88 Issue 22 | pp. 13-18)

Custom manufacturers take on drug solubility issues to help pharmaceutical firms move products through development.

Solubility Solutions: Formulation Routes To Improve Solubility

(May 31, 2010 | Vol. 88 Issue 22 | p. 17)

Nicer Than Needles

(May 31, 2010 | Vol. 88 Issue 22 | pp. 27-30)

Delivering biologic drugs orally, instead of by injection, calls for tricking the human body.

Sowing The Seeds Of Oil Customization(Member Content)

(May 31, 2010 | Vol. 88 Issue 22 | pp. 52-55)

Breeding and biotechnology team up to deliver seed oils with tailored profiles.

A Most Versatile Enzyme

(May 31, 2010 | Vol. 88 Issue 22 | pp. 56)

Natural Products: A single enzyme catalyzes thioether cyclization of peptides with nearly no specificity for amino acid sequence.

Dispute Flares Over Ardi

(May 31, 2010 | Vol. 88 Issue 22 | pp. 10)

Paleontology: Disagreement concerns hominid's habitat and classification.

Similar Molecules, Opposite Effects

(May 31, 2010 | Vol. 88 Issue 22 | pp. 11)

Protein Interactions: Small-molecule analogs affect heat-shock protein complex in different ways.

Selective CO Oxidation

(May 31, 2010 | Vol. 88 Issue 22 | pp. 12)

Catalysis: Low-coordination iron sites at interface between oxide and metal drives the conversion.

Science & Technology Concentrates (Member Content)

(May 31, 2010 | Vol. 88 Issue 22 | pp. 50-51)

• Protein-Lipid Alliances
• Computer simulations provide a better picture of the poorly understood dynamics of biological membranes
• Exercise Metabolites Signal Fitness Levels
• A study shows that metabolic signatures can clearly distinguish more fit from less fit individuals
• Microbes Degrade Biodiesel To A Corrosive Mix
• Methyl esters that make up biodiesel can speed corrosion of carbon steel used in pipelines and storage tanks
• Custom Proteins Clarify Splicing Mechanism
• Proteins that splice themselves get a jump start from a special branched conformation, a study suggests
• Skipping Steps To Skipped Polyenes
• Synthetic strategy offers more efficient routes to polyunsaturated fatty acids and other compounds
• Single-Molecule Assay Detects Cancer
• Quanterix has developed an assay that is ultrasensitive for detecting a cancer biomarker
• Polymetallic Wire Sports Redox Caps
• A redox-active metal-polyyne molecular wire demonstrates long-range electronic communication
• Cytokine Detection Illuminates Allergic Responses
• New technique improves quantitation of multiple cytokines released from immune cells

May 24, 2010

LIMS In The Cloud

(May 24, 2010 | Vol. 88 Issue 21 | pp. 12-16)

Laboratory information management system software for small users makes maximum use of the Internet.

Probing Radioactive Materials(Member Content)

(May 24, 2010 | Vol. 88 Issue 21 | pp. 34-35)

Use of NMR to study nuclear materials and the chemistry of f-block elements grows.

A Question Of Identity

(May 24, 2010 | Vol. 88 Issue 21 | pp. 36-37)

Multiple initiatives aim to unambiguously identify individual scientists so they're credited for their work.

C&EN Talks With Yuan T. Lee(Member Content)

(May 24, 2010 | Vol. 88 Issue 21 | p. 38)

Nobel Laureate and president-elect of an international scientific organization, Lee hopes to promote sustainability.

Dendrimersomes Debut

(May 24, 2010 | Vol. 88 Issue 21 | p. xxx)

Supramolecular Chemistry: Self-assembled dendrimer-based structures could deliver drugs, other substances.

New Start For Pd(III) Chemistry

(May 24, 2010 | Vol. 88 Issue 21 | p. xxx)

Organometallic Chemistry: Complex with a carbon-Pd(III) bond makes C-C bonds.

Synthetic Biology Takes A Step Forward

(May 24, 2010 | Vol. 88 Issue 21 | p. xxx)

Genetic Engineering: Team grows bacterial DNA in yeast, transplants it to host cell, which then replicates.

Reviving The Malaria Fight

(May 24, 2010 | Vol. 88 Issue 21 | p. xxx)

Open Innovation: Companies, consortium publicly disclose scores of potential antimalarial leads.

Science & Technology Concentrates (Member Content)

(May 24, 2010 | Vol. 88 Issue 21 | pp. 32-33)

• Semiconductor Stacks
• A new method for growing large pieces of GaAs could boost the material’s use in electronic devices.
• P,N Ligand Advances Ammonia Coupling
• Palladium system enables chemists to use ammonia to make arylamines at room temperature.
• Density Analysis By Magnetic Levitation
• Harvard chemists have devised a simple tool for analyzing food and water based on density.
• Rapid Water-Ion Dynamics Revealed
• New spectroscopic techniques provide femtosecond details of water-ion interactions in solution.
• Molecules Impede HIV Replication By Design
• A class of designed compounds inhibits HIV replication by disrupting protein-protein interactions.
• Mass Spec Imaging Probes Implant Immune Response
• New technique gauges the biocompatibility of materials used for drug delivery and tissue engineering.
• New Oxygen-Evolving Catalyst Unveiled
• With an eye toward solar energy use, a nickel-borate catalyst could improve on the electrochemical splitting of water.
• Metal-Free Alkene Dioxygenation
• Greener method avoids transition-metal catalysts by using O₂ as an oxidant and oxygen-atom source.

May 17, 2010

Preserving Cosmetics

(May 17, 2010 | Vol. 88 Issue 20 | pp. 13-16)

Fear of potential carcinogens in personal care products plagues cosmetic ingredients makers.

In Names, History And Legacy (Member Content)

(May 17, 2010 | Vol. 88 Issue 20 | pp. 31-33)

Chemistry and culture collide in the coining of namesake reactions.

NOBCChE Inspires Young Scientists

(May 17, 2010 | Vol. 88 Issue 20 | pp. 34-35)

Annual meeting of black chemists and chemical engineers features host of role models and pioneers.

NOBCChE's 2010 Science Competitions

(May 17, 2010 | Vol. 88 Issue 20 | Web Exclusive)

Middle and high school students win big at organization's national science bowl and fair.

Cleaning Up The Gulf Oil Spill

(May 17, 2010 | Vol. 88 Issue 20 | pp. 36-37)

Response teams use multiple techniques, including a new one, to try to protect coastal wetlands.

Rise Of The DNA Robots

(May 17, 2010 | Vol. 88 Issue 20 | p. 8)

Nanotechnology: Molecular machines stroll autonomously, transport cargo.

Predicting Drugs' Harm To Kidneys

(May 17, 2010 | Vol. 88 Issue 20 | p. 10)

Drug Safety: Biomarkers in urine can better predict injurious effects of drug candidates.

Bacteria Chew Up Atrazine

(May 17, 2010 | Vol. 88 Issue 20 | p. 12)

Synthetic Biology: Engineered E. coli seek and destroy herbicide.

Science & Technology Concentrates (Member Content)

(May 17, 2010 | Vol. 88 Issue 20 | pp. 29-30)

• Silver Spurs Cycloadditions
• Nanoparticles make their debut as catalysts for organic synthesis in a Diels-Alder reaction.
• How Spider Silk Pulls Itself Together
• A pair of structural studies shed light on how spiders transform a protein fluid into tough silk fibers.
• Profiling Tumor Cells
• Cancerous and noncancerous cells can be distinguished by comparing Raman spectral lines.
• Hollow Titania Fibers Improve Solar Cells
• TiO2 fibers made on a cotton template outperform TiO2 particles in photovoltaic device tests.
• Too Much Carbon Dioxide Limits Plants
• Study provides details on how excess CO₂ inhibits assimilation of nitrate into proteins in plants.
• H-Bonding Enables Molecular Dancing
• Transient adsorbed hydrogen facilitates diffusion of organic molecules across a titania surface.
• Healthy Omega-3 Fatty Acid Metabolites
• Scientists identify heart-healthy and anti-inflammatory compounds in foods and dietary supplements.
• Valeric Biofuels Move Forward
• Shell researchers improve a reaction step in the conversion of levulinic acid to valerate esters.

May 10, 2010

Common Ground For Going Green

(May 10, 2010 | Vol. 88 Issue 19 | pp. 38-41)

Effort to develop a chemical industry standard is driven by the need to share comparative data.

Green Chemical Standard's Potentially Broad Reach

(May 10, 2010 | Vol. 88 Issue 19 | pp. Web Exclusive)

New standard could benefit chemical makers and consumer products manufacturers by promoting information exchange.

Zeroing In On Golden Mechanisms

(May 10, 2010 | Vol. 88 Issue 19 | pp. 42-44)

Studies elucidate catalytic reaction steps yet key questions remain unsettled.

New Oil Clean-Up Technique Tested

(May 10, 2010 | Vol. 88 Issue 19 | p. 8)

Environment: Novel use of dispersants could mitigate damage from BP spill in the Gulf of Mexico.

Plastic Antibodies Target Peptide

(May 10, 2010 | Vol. 88 Issue 19 | p. 10)

Nanotechnology: Molecularly imprinted nanoparticles remove bee toxin from blood.

Illuminating Tumor Cells

(May 10, 2010 | Vol. 88 Issue 19 | p. 12)

Diagnostics: Fluorescent agents target enzyme in cancer cells.

Seeing Atomic Spin

(May 10, 2010 | Vol. 88 Issue 19 | p. 12)

Physicists capture the first images of atomic "up" and "down" electrons.

Science & Technology Concentrates (Member Content)

(May 10, 2010 | Vol. 88 Issue 19 | pp. 36-37)

• Refined Silver Nanowires
• Long, narrow nanowires make transparent electrodes for lower cost electronic devices
• Arsenic Speciation Key To Poisoning Risk
• Dermal exposure to arsenic compounds highly depends on the chemical form of the toxic substances
• How Aging Damages Memory
• Exploring the mechanism behind memory impairment points to histone acetylation as a therapeutic target
• Manipulating Stem Cells Through Their Metabolites
• Stem-cell differentiation can be regulated by controlling unsaturated metabolites
• Cobalt(IV) Caught In Water-Splitting Action
• Oft-implicated cobalt intermediate in water oxidation observed by EPR spectroscopy
• Multitasking Metformin
• Newly discovered twist in the mechanism of the diabetes drug could lead to a cancer treatment
• Bandages For Fighting Bad Bacteria
• Pathogenic bacteria become the agents of their own destruction in a new antimicrobial system
• Chemistry’s First Definitive Silylidyne
• As a metal alkylidyne analog, Mo≡Si complex broadens the scope of organometallic chemistry

May 3, 2010

Time For Tau(Member Content)

(May 3, 2010 | Vol. 88 Issue 18 | pp. 36-39)

Long overshadowed by amyloid-β, tau protein is gaining ground as a therapeutic target in alzheimer's disease.

The Science Of Feeding Soldiers

(May 3, 2010 | Vol. 88 Issue 18 | pp. 40-41)

Chemical innovations make tasty battlefield meals, ready-to-eat. With Video.

Enzyme's Active Site Sighted

(May 3, 2010 | Vol. 88 Issue 18 | pp. 40-42)

Methane monooxygenase may use dicopper center to make methanol.

Biotech Alfalfa Ban Questioned

(May 3, 2010 | Vol. 88 Issue 18 | p. 8)

Biotechnology: Supreme Court hears first case involving a genetically modified crop.

Breaking Up Biofilms

(May 3, 2010 | Vol. 88 Issue 18 | p. 8)

Microbiology: Amino acids dismantle bacterial communities.

Academy Elects New Members

(May 3, 2010 | Vol. 88 Issue 18 | p. 10)

Honors: Ninety scientists join the ranks of the National Academy of Sciences.

Creating Fuel From Water

(May 3, 2010 | Vol. 88 Issue 18 | p. 11)

Sustainable Energy: New materials aim to improve the path to dihydrogen.

Science & Technology Concentrates (Member Content)

(May 3, 2010 | Vol. 88 Issue 18 | pp. 34-35)

• Testosterone’s Manly Role
• New details are out on how sex hormones affect masculine physiology at an early age.
• Stick-To-Itiveness Underemphasized In Drug Design
• Stony Brook chemists say the time a drug remains bound to its target needs closer scrutiny.
• Blood Lead Levels Ebb After Hurricanes
• Flooding in New Orleans after Katrina and Rita reduced lead in soils—and by extension in children.
• Frosty Asteroid Leaks Water Into Space
• An asteroid between Mars and Jupiter is unexpectedly covered in water ice and organic compounds.
• Deoxofluorination Reagents Proliferate
• Fluorine Chemistry: New generation of safer compounds will benefit pharmaceuticals and agrochemicals.
• Nanopowders Improve Iron Bioavailability
• Novel materials are a promising means of fortifying foods without changing the color or taste.
• Methyl Lactate From Sugar, Catalytically
• One-pot acid-catalyzed process offers an alternative to standard fermentation processing.
• Nanoruthenium Readily Reduces Aromatics
• Stabilizing Ru(0) nanoclusters within a zeolite framework permits solventless hydrogenations.

April 26, 2010

Rare And Neglected(Member Content)

(April 26, 2010 | Vol. 88 Issue 17 | pp. 36-38)

Drug researchers urge greater support for diseases outside the mainstream.

Gypsy Moth Control

(April 26, 2010 | Vol. 88 Issue 17 | pp. 40-42)

Scientists have used a plethora of chemicals and techniques to manage the invasive pest. With Photo Gallery.

Volcanic Ash Data Sought

(April 26, 2010 | Vol. 88 Issue 17 | p. 8)

Atmospheric Chemistry: Chemists launch research efforts to probe aerosols from Eyjafjallajokull's eruption.

Biomarkers Help Hit The Bull's-Eye

(April 26, 2010 | Vol. 88 Issue 17 | p. 8)

Personalized Medicine: Cancer therapy is more effective when target is identified.

Solving A Protein Mystery

(April 26, 2010 | Vol. 88 Issue 17 | p. 9)

Protein Synthesis: Discovery connects transcription and translation in bacteria.

Silken Electronics

(April 26, 2010 | Vol. 88 Issue 17 | p. 10)

Biomaterials: Electrode arrays constructed from films of silk cling to the brain.

Carbene Size Guides Coupling

(April 26, 2010 | Vol. 88 Issue 17 | p. 10)

Organometallic Chemistry: Ligand bulk affects outcome of aldehyde-alkyne pairing.

Science & Technology Concentrates (Member Content)

(April 26, 2010 | Vol. 88 Issue 17 | pp. 34-35)

• Nanopatterning Gets Smaller
• IBM researchers use a heated silicon atomic force microscope tip to etch out 15-nm features
• Sunlight-Driven Nanowire Catalysts
• Novel platinum-silicon-silver integrated nanowire device has improved efficiency in the visible region
• Electrospun Fabric Thwarts Microbes
• Method should improve technology for making antibacterial surgical masks and hospital gowns
• Phototriggers Track Protein Dynamics
• Tetrazine-based probes inserted into peptides open a new window into structure evolution
• Probing A Protein’s Elusive Chromophore
• p-Coumaric acid study helps unravel the processes that drive a popular bacterial photoreceptor

April 19, 2010

The Paper Chase

(April 19, 2010 | Vol. 88 Issue 16 | pp. 13-17)

With the help of specialty chemicals, papermakers seek endless recycling of scarce fibers.

Space-Dust Science(Member Content)

(April 19, 2010 | Vol. 88 Issue 16 | pp. 36-38)

ACS Meeting News: Elucidating the chemistry of interstellar dust particles is key to understanding early planets.

Enabling Chemistry Experiments In Space(Member Content)

(April 19, 2010 | Vol. 88 Issue 16 | p. 36)

The Gastric Bypass Pill(Member Content)

(April 19, 2010 | Vol. 88 Issue 16 | pp. 39-40)

ACS Meeting News: Drug designers take aim at molecules that might mimic bariatric surgery's ability to halt diabetes.

Bioinspired Material Debuts

(April 19, 2010 | Vol. 88 Issue 16 | p. 7)

Peptoid Crystals: Peptide analogs self-assemble to form versatile 'molecular paper'.

Boron-Oxygen Triple Play

(April 19, 2010 | Vol. 88 Issue 16 | p. 8)

Multiple Bonding: First isolable compound with a B≡O bond, thanks to platinum coordination.

A Shield Against Ricin

(April 19, 2010 | Vol. 88 Issue 16 | p. 10)

Drug Development: Small molecule defeats potential bioterrorism agent.

Science & Technology Concentrates (Member Content)

(April 19, 2010 | Vol. 88 Issue 16 | pp. 34-35)

• Sweeter Enzyme Inhibitor
• A novel glycosyltransferase inhibitor could aid glycobiology research and drug discovery
• Phosphate Glass Boosts Barrier Films
• Coextrusion of glass with a copolymer increases film elasticity and reduces oxygen permeability
• Cigarette Butts Yield A Chemical Rebuttal
• Extracting anticorrosion compounds from spent cigarettes could benefit the environment and steel
• Dispersing Nanotubes Renders Them Nontoxic
• Mouse study indicates that nanotube aggregates, not individual tubes, lead to pulmonary toxicity
• Viral Nanostrucutres Assist Light-Driven Water Oxidation
• Genetically engineered virus acts as a scaffold for assembling an artificial photosynthetic system
• Diclofenac In The Environment
• Several studies on the anti-inflammatory drug in wastewater offer new toxicity data and a remediation technology
• Primordial Path To Painkillers
• Heat-stable enzyme from an Archaea microbe facilitates anti-inflammatory drug synthesis
• Thick-And-Thin Nanowire Segments
• A new electrochemical method yields nanowires with alternating dense and porous sections

April 12, 2010

Drug Candidates' Big Reveal(Member Content)

(April 12, 2010 | Vol. 88 Issue 15 | pp. 30-33)

ACS Meeting News: Medicinal chemists unveil potential drugs for brain, autoimmune, liver ailments.

Bringing Outdoor Chemistry Indoors(Member Content)

(April 12, 2010 | Vol. 88 Issue 15 | pp. 34-36)

ACS Meeting News: Symposium brings together atmospheric and indoor chemistry communities.

Smoke Signals

(April 12, 2010 | Vol. 88 Issue 15 | pp. 37-38)

Seeds sprout in the ashes of forest fires, thanks to small molecules in smoke.

The 'Sus' Word(Member Content)

(April 12, 2010 | Vol. 88 Issue 15 | p. 39)

Insights: Sustainability, the main attraction at last month's ACS meeting, has leapt to the forefront of chemical thinking.

Graphene's Thermal Conductivity

(April 12, 2010 | Vol. 88 Issue 15 | p. 5)

Materials: Ultrathin carbon dissipates heat well when supported by a solid.

Data Storage Goes Organic

(April 12, 2010 | Vol. 88 Issue 15 | p. 6)

Materials Science: Device relies on changes in azo conductivity.

Obesity Clue In View

(April 12, 2010 | Vol. 88 Issue 15 | p. 9)

Structural Biology: Close-up of methyl-clipping enzyme might help probe its obesity connection.

Element 117 Created

(April 12, 2010 | Vol. 88 Issue 15 | p. 9)

Nuclear Chemistry: Elusive superheavy element fills out picture of periodic table's extremes.

Science & Technology Concentrates (Member Content)

(April 12, 2010 | Vol. 88 Issue 15 | pp. 28-29)

• Fruit Fly's Water
• Ion channel protein in fruit flies' taste neurons hints at how animals regulate water intake.
• Arsenic Binding Defeats Leukemia
• Arsenic trioxide’s efficacy comes from binding to a cysteine-rich region of a cancer protein, leading to protein degradation.
• A New Hydroxyl Protecting Group
• (2-Nitrophenyl)acetyl works well at masking hydroxyl moieties in the synthesis of sugars.
• Slipping In An Acetyl For Enzyme Control
• Controlled acetylation inhibits isomerase activity of cyclophilin A, which could lead to new antiviral treatments.
• Salty Coronene Sorts Carbon Nanotubes
• Scientists take advantage of organic salt's π interactions to separate metallic and semiconducting nanotubes.
• From Solid Block Copolymer To Highly Porous Membrane
• Polyethylene/polylactide copolymer, stripped of its polylactide segments, becomes a useful porous material.
• Nitroxyl Lights Up Copper Complex
• Copper-based fluorescent probe is a selective indicator for HNO in biological systems.
• Novel Redox Couples Could Aid Solar Cells
• Metallacarborane and sulfur compounds should improve on iodide systems in dye-sensitized solar cells.

April 5, 2010

Treating Alzheimer's

(April 5, 2010 | Vol. 88 Issue 14 | pp. 12-17)

Late-stage clinical trials will soon tell whether blocking amyloid-β can slow the disease.

Food Detectives

(April 5, 2010 | Vol. 88 Issue 14 | pp. 36-37)

ACS Meeting News: Analytical chemists devise methods to confirm foods are what they claim to be.

Modeling Geochemistry(Member Content)

(April 5, 2010 | Vol. 88 Issue 14 | pp. 39-40)

ACS Meeting News: Increasing computational power makes possible simulations of geology's nitty-gritty chemistry.

Thorium Complex Almost Maxes Out

(April 5, 2010 | Vol. 88 Issue 14 | p. 8)

Inorganic Chemistry: 15-Coordinate thorium aminodiboranate sets a record, just one bond short of a perfect 16.

Gene Patents Ruled Invalid

(April 5, 2010 | Vol. 88 Issue 14 | p. 9)

Biotechnology: Industry says setback will not undermine multi-billion-dollar business.

Countering Sleeping Sickness

(April 5, 2010 | Vol. 88 Issue 14 | p. 10)

Drug Development: New compounds cure mice of early-stage infections.

Science & Technology Concentrates (Member Content)

(April 5, 2010 | Vol. 88 Issue 14 | pp. 34-35)

• Imaging Industrial-Type Catalysts
• Study yields element-specific, atomic-resolution view of nanostructured solid
• Graphene Ferries DNA
• Atom-thick carbon sheets shepherd oligonucleotides into cells
• Twisting Hepatitis C Out Of Commission
• Structure shows how antiviral agent straightens RNA bend that virus uses to attack its hosts
• Compulsive Eating Resembles Addiction
• Eating high-fat, high-calorie food shown to be a hard-to-break habit
• Proteins Tied In Knots
• Knots found in denatured forms of two proteins
• Helium Bonding Possibilities Explored
• Helium binding to hypervalent complexes could lead to new type of noble gas chemistry
• Bright Lights For Imaging
• Fluorinated dyes take a laser licking but keep on ticking
• Planar Anthocyanin Conformer Leads To Color Change
• Study reveals mechanism of red-blue shift that occurs when flower and fruit colorants freeze

March 29, 2010

Probing Nanotoxicity

(March 29, 2010 | Vol. 88 Issue 13 | pp. 32-34)

Analytical methods provide insight into hazards of nanomaterials.

Doubling Up On Mass Analysis

(March 29, 2010 | Vol. 88 Issue 13 | pp. 35-37)

Coupling ion mobility spectrometry with mass spec provides sensitivity to analyte mass, charge, and shape.

Drugs In The Environment (Member Content)

(March 29, 2010 | Vol. 88 Issue 13 | pp. 23-24)

Stakeholders consider ways to reduce the impact of drugs that get past sewage treatment plants and into nature.

Greener Drugs: Benign-By-Design Strategies

(March 29, 2010 | Vol. 88 Issue 13 | WEB EXCLUSIVE)

Favored Flavors

(March 29, 2010 | Vol. 88 Issue 13 | pp. 25-26)

To ensure kosher dietary standards, rabbis need to account for every molecule.

What's That Stuff? Body Armor

(March 29, 2010 | Vol. 88 Issue 13 | WEB EXCLUSIVE)

High-tech ceramics protect soldiers from a wide range of ballistic threats.

Radical Kind Of Methyl Transfer

(March 29, 2010 | Vol. 88 Issue 13 | p. 9)

ACS Meeting News: Enzyme involved in antibiotic resistance catalyzes radical C-methylation.

Addition Against The Grain

(March 29, 2010 | Vol. 88 Issue 13 | p. 10)

ACS Meeting News: Defying classic rules, reaction makes new chiral centers.

Curbing Diesel Engines' Cost

(March 29, 2010 | Vol. 88 Issue 13 | p. 11)

Materials Science: New catalyst could sidestep use of costly Pt in emissions control technology.

Science & Technology Concentrates (Member Content)

(March 29, 2010 | Vol. 88 Issue 13 | pp. 42-43)[an error occurred while processing this directive]

March 22, 2010

Priestley Medalist

(March 22, 2010 | Vol. 88 Issue 12 | pp. 14-18)

Richard Zare receives the 2010 award for applying lasers, as well as creativity and enthusiasm, to molecular research.

Wine's Mycotoxin Profile Grows(Member Content)

(March 22, 2010 | Vol. 88 Issue 12 | p. 44)

Another fungal toxin associated with grains is present in wines worldwide.

C&EN Talks With Marcus Eriksen And Anna Cummins(Member Content)

(March 22, 2010 | Vol. 88 Issue 12 | p. 45)

Researchers combine education and outdoor adventure to help combat plastic pollution.

Switchable Solvents

(March 22, 2010 | Vol. 88 Issue 12 | p. 46)

Green Chemistry: Using CO₂ as a reversible trigger, novel solvent systems aim to facilitate greener reactions and product separations.

What's That Stuff? Wasabi

(March 22, 2010 | Vol. 88 Issue 12 | p. 48)

In condiments, horseradish stands in for the real thing.

Gold Dust Extends Raman's Reach

(March 22, 2010 | Vol. 88 Issue 12 | p. 10)

Spectroscopy: Nanoparticles open scattering technique to new applications.

New Function For tRNA

(March 22, 2010 | Vol. 88 Issue 12 | p. 12)

Cell Biology: Transfer RNA keeps apoptosis in check.

Maximizing Codeine

(March 22, 2010 | Vol. 88 Issue 12 | p. 13)

Plant Biochemistry: Researchers identify enzymes that convert codeine to morphine in poppy plants.

Science & Technology Concentrates (Member Content)

(March 22, 2010 | Vol. 88 Issue 12 | pp. 42-43)

• Quadruple Phthalocyanines
• A homogeneous cobalt polyoxometalate catalyst splits water while avoiding oxygen-promoted degradation.
• Higher Capacity Lithium-Ion Battery
• Novel design that includes tin, sulfur, and a polymer outperforms today’s commercial units.
• Rough And Green Plasma Process For Treating PET Fibers
• A helium-argon plasma could be a better approach to processing textile fibers than current wet chemical methods.
• Super-Duper Shape-Memory Alloy
• Unique iron-based alloy has unprecedented superelasticity.
• Fish And Hormones
• A study of treated wastewater is the first to report an environmental risk for the birth-control drug levonorgestrel.
• Shaken And Stirred Self-Replication
• Different-sized molecules can come from one combinatorial library, depending on the agitation method.
• Ozonolysis Goes With The Flow
• Chemists have designed a flow reactor system for safer and greener ozonolysis of alkenes.
• Methylation Approach Aids Cyclosporine A Synthesis
• A method for forming multiple tertiary amides in large biomolecules relies on an isonitrile coupling reaction.

March 15, 2010

Food That Smells Too Good To Eat(Member Content)

(March 15, 2010 | Vol. 88 Issue 11 | pp. 51-52)

Enhancing the aroma of food might help dieters eat less.

Neuroscience: The Two Faces Of Pleasure And Desire

(March 15, 2010 | Vol. 88 Issue 11 | Web Exclusive)

Web Exclusive with video.

Wasps' Nursery Defense

(March 15, 2010 | Vol. 88 Issue 11 | p. 54)

Expert panel recommends screening for effects of chemicals on critical disease pathways.

Questions Arise Over Interaction Between Brain Cells

(March 15, 2010 | Vol. 88 Issue 11 | p. 57)

Chemical Ecology: Beewolf digger wasps use bacterial antibiotics to protect the next generation.

Unraveling Thalidomide's Tragic Effects

(March 15, 2010 | Vol. 88 Issue 11 | p. 9)

Cell Biology: Researchers discover a protein involved in causing birth defects related to the drug.

Chemistry Over Colorado

(March 15, 2010 | Vol. 88 Issue 11 | p. 10)

Chlorine Surprise: Reactions may process up to one-fifth of inland nitrogen oxide emissions.

New Chains For Ionic Liquids

(March 15, 2010 | Vol. 88 Issue 11 | p. 11)

Molecular Design: Kinked fatty acid side chains create a new class of low-melting-point salts.

Science & Technology Concentrates (Member Content)

(March 15, 2010 | Vol. 88 Issue 11 | pp. 48-49)

• Protected Oxidation Catalyst
• A homogeneous cobalt polyoxometalate catalyst splits water while avoiding oxygen-promoted degradation
• New Method Flags Protein Acetylation
• Alkyne analogs of acetyl-CoA deliver a faster, safer method to ID acetylated proteins for biological studies
• Ritalin Acts Through Two Brain Receptors
• Neuroscientists find that the drug commonly used to treat ADHD activates two types of dopamine receptors
• Stirring Liquid Metals Without A Stir Bar
• Heat and a magnetic field lead liquid lithium to swirl on its own, like a whirlpool
• A Quadruple Shape-Shifter
• Nafion, the sulfonated fluoropolymer, can take on an unprecedented four different shapes as a shape-memory material
• D For Immune Defense
• Vitamin D is a crucial factor in activating the human immune system
• Pulled Polyethylene Takes The Heat
• Stretched-out polymer fibers conduct heat as well as most metals, a fact that could lead to new heat-transfer materials
• Interconverting Superstructures
• Simple chemical stimuli cause surface films to flip-flop between architectures

March 8, 2010

Laser Turns 50

(March 8, 2010 | Vol. 88 Issue 10 | pp. 13-17)

C&EN celebrates a half-century of a device that shaped modern chemistry.

Predicting Amyloid Formation(Member Content)

(March 8, 2010 | Vol. 88 Issue 10 | pp. 38-39)

Computer algorithms find fibril-forming sequences in nearly all proteins.

Rethinking Breast Cancer Toxicology(Member Content)

(March 8, 2010 | Vol. 88 Issue 10 | pp. 40-41)

Expert panel recommends screening for effects of chemicals on critical disease pathways.

Superconductor Is Simply Organic

(March 8, 2010 | Vol. 88 Issue 10 | p. 7)

Materials: Graphene subunit is a new class of organic high-temperature superconductors.

Methane From Arctic Ocean

(March 8, 2010 | Vol. 88 Issue 10 | p. 10)

Climate Science: Amount of the greenhouse gas seeping from undersea deposits is much greater than expected.

Glycoproteins Made To Order

(March 8, 2010 | Vol. 88 Issue 10 | p. 11)

Chemical Biology: First homogeneous, eukaryote-type N-glycoproteins from prokaryotes.

Science & Technology Concentrates (Member Content)

(March 8, 2010 | Vol. 88 Issue 10 | pp. 36-37)

• Carbon Fixation Single File
• Blue-green algae arrange carbon fixation enzyme compartments for maximum efficiency
• Hydrated Electrons Probed Experimentally
• Determining fundamental properties of electrons in aqueous solution could provide the key to understanding their role in breaking bonds
• Mussels Cling With Irod-Clad Complexes
• Iron-dopa crosslinks give byssal thread cuticles hardness and extensibility
• Agent Targets Bacterial Virulence Factor
• Compound fights tuberculosis by inhibiting a bacterial enzyme needed for infectivity or survival in the host.
• Atrazine Feminizes Male Frogs
• Widely used weed killer transforms male frogs into functional females that can produce viable eggs
• Patterning Turns ‘Darkest Material’ Iridescent
• Carbon nanotube films can go from black to brightly colored when patterned
• Carbon Dioxide Alters Vegetable Biosynthesis
• Greenhouse gas may change the flavor of broccoli
• Amyloid β May Have A Good Side
• Protein associated with Alzheimer’s disease has antimicrobial activity

March 1, 2010

The More The Merrier(Member Content)

(March 1, 2010 | Vol. 88 Issue 9 | pp. 36-37)

New evidence proves that RNAs can take on multiple folded forms, just as proteins do.

Lassoing Your Target(Member Content)

(March 1, 2010 | Vol. 88 Issue 9 | pp. 38-39)

Unusual peptides with pharmacological potential are amenable to engineering.

Croconic Acid Is Ferroelectric(Member Content)

(March 1, 2010 | Vol. 88 Issue 9 | p. 41)

Discovery suggests organic ferroelectrics may not be as elusive as once thought.

Inside The Beauty Lab

(March 1, 2010 | Vol. 88 Issue 9 | pp. 17-22)

In pursuit of innovative products, L’Oréal R&D scientists address beauty 'from the cell to the gesture'.

Treading Lighter

(March 1, 2010 | Vol. 88 Issue 9 | Web Exclusive)

L’Oréal is increasing its commitment to sustainability when developing new ingredients.

A Protein That Aids Forgetting

(March 1, 2010 | Vol. 88 Issue 9 | p. 12)

Neuroscience: Protein kinase Rac helps the fruit fly brain remove memories.

New Way To Screen a-Conotoxins

(March 1, 2010 | Vol. 88 Issue 9 | p. 13)

Drug Discovery: Work could lead to medications based on these neuroactive peptides.

Heavy Elements

(March 1, 2010 | Vol. 88 Issue 9 | p. 15)

International body dubs element 112 copernicium.

Science & Technology Concentrates (Member Content)

(March 1, 2010 | Vol. 88 Issue 9 | pp. 34-35)

• Barnacles Stick With Amyloid Adhesive
• Traditionally associated with disease, amyloid gives the crustaceans their grip
• Nanotube Thermocell Harvests Waste Heat
• Device could capture energy lost as low grade heat in industrial waste streams
• Dual Benefits For Big Rings
• Bifunctional reagent adds to the tool kit for making macrocycles
• Refined Path From Biomass To Biofuel
• Flow-reactor system converts γ-valerolactone into ready-to-use gasoline and jet fuel
• New Experiments May Resolve Doubts About Enzyme’s Mechanism
• ¹⁹F NMR experiments seem to close controversy over how phosphoryl is transferred
• Rethinking Comet Origins
• New evidence suggests comet-forming processes may resemble those of meteorites
• Phase Switching Without Detagging
• Boronic acid-based procedure for separating organic reaction products is more streamlined than predecessors
• Long-Distance Wiring
• Symbiotic bacteria split redox reactions over long distances

February 22, 2010

Making Use Of Neutrons

(February 22, 2010 | Vol. 88 Issue 8 | pp. 36-39)

Subatomic particles provide new ways to study structure, dynamics of materials.

Spiders Seeking Sex

(February 22, 2010 | Vol. 88 Issue 8 | p. 40)

Arachnid courtship pheromones point to a new class of natural products.

Activation Of Protein Tags

(February 22, 2010 | Vol. 88 Issue 8 | p. 8)

Enzymology: To prepare biological labels for attachment, E1 enzymes dramatically remodel themselves.

Expanding The Genetic Code

(February 22, 2010 | Vol. 88 Issue 8 | p. 9)

Molecular Biology: New ribosome can install multiple unnatural amino acids in a protein.

A New Facet Of Drug Resistance

(February 22, 2010 | Vol. 88 Issue 8 | p. 10)

Antibiotics: Low doses of one medication can cause resistance to that one and others.

Cellular Joy Stick

(February 22, 2010 | Vol. 88 Issue 8 | p. 11)

Biochemistry: Acetylation controls much more biology than previously expected.

Science & Technology Concentrates (Member Content)

(February 22, 2010 | Vol. 88 Issue 8 | pp. 34-35)

• Carbohydrate’s Silicate Origins
• Sugar-silicate complexes may have been key to early synthesis of stereospecific carbohydrates on Earth
• Candy-Coated Live Vaccines Stay Active
• Encapsulating live vaccines with trehalose and sucrose is just as effective as refrigeration for storage
• Meteoric Review Hints At Molecular Diversity
• Closer look at Murchison meteorite unveils possibly millions of organic compounds lurking within
• Sugary Boost Without The Calories
• Heterocyclic compounds act on taste receptors to enhance the sweetness of sugar and artificial sweeteners
• Multifunctional Ionic Liquid Drugs
• Formulating drugs as room-temperature liquid salts offers a new approach to drug design and delivery
• Cocatalyst Tag Team
• Pair of small molecules cooperate to make optically pure products from reactive cationic intermediate
• Sweet And Oily Biodiesel Cocktail
• Coprocessing carbohydrates and triglycerides derived from plant seeds significantly boosts biodiesel production
• Veterinary Drug Might Work To Treat Human River Blindness
• Closantel, used to treat sheep and cattle infected with liver flukes, could combat tropical disease caused by a nematode

February 15, 2010

Slaying Cancer At Its Roots(Member Content)

(February 15, 2010 | Vol. 88 Issue 7 | p. 46-47)

Revival of classic hypothesis opens auspicious avenues to treatments.

Cancer Connections Everywhere

(February 15, 2010 | Vol. 88 Issue 7 | Web Exclusive)

Researchers worldwide are studying the many links between cancer and metabolism.

Very Cool Chemistry

(February 15, 2010 | Vol. 88 Issue 7 | p. 12)

Fundamentals: Reactions at nano-Kelvin temperatures illustrate the role of quantum mechanics in reactivity.

Precise Route To Polypropylenes

(February 15, 2010 | Vol. 88 Issue 7 | p. 13)

Polymer Chemistry: Novel chain-transfer process expands range of possible materials.

After The Smoke Clears

(February 15, 2010 | Vol. 88 Issue 7 | p. 14)

Indoor Chemistry: Tobacco residues react with chemicals in air to form dangerous products.

Science & Technology Concentrates (Member Content)

(February 15, 2010 | Vol. 88 Issue 7 | p. 45)

• Heavy Element Gets Weighed
• Ion-trap mass spec technique allows direct weighing of nobelium isotopes, a first for a transuranium element
• Long Oligofurans
• Oligofurans were once too short, but now with as many as nine rings, they are back in vogue as electronic materials
• Greener Methylations
• Dimethyl carbonate is a top methylating reagent for a high-yield, supercritical CO₂ synthesis of methyl ethers
• Carbenes Made Easy
• New route to versatile azavinyl reactive species eschews unstable reagents
• Electronic Switch Crafted From DNA
• Potassium ions control contraction and expansion of a designed double helix, turning current on and off

February 8, 2010

Back To The Future With Stem Cells

(February 8, 2010 | Vol. 88 Issue 6 | p. 50-53)

Reprogramming the fate of cells with small molecules.

Choosing One Among Many(Member Content)

(February 8, 2010 | Vol. 88 Issue 6 | p. 54)

Chemists get better at oxidizing specific C-H bonds.

C&EN Talks WIth Paul Alivisatos(Member Content)

(February 8, 2010 | Vol. 88 Issue 6 | p. 55)

LBNL's new director focuses on renewable energy, climate.

Amantadine's Double Bind

(February 8, 2010 | Vol. 88 Issue 6 | p. 10)

Mode of Action: New finding on flu drug's binding to virus proton channel could aid drug design.

Reaction-Driven Mixing

(February 8, 2010 | Vol. 88 Issue 6 | p. 11)

Fluid Dynamics: Chemical interactions drive convection and stirring.

Progesterone Proof

(February 8, 2010 | Vol. 88 Issue 6 | p. 13)

Natural Products: New evidence confirms suspicion that plants can also make well-known hormone.

Science & Technology Concentrates (Member Content)

(February 8, 2010 | Vol. 88 Issue 6 | pp. 48-49)

• Mosquito Olfaction
• Studying how mosquito odorant receptors respond to “human volatiles” could improve control of the disease-transmitting insects
• Tree Bark Inspires Vaccine Adjuvants
• Synthetic saponin analogs have potential to improve immune response to vaccines and thus improve vaccine efficacy
• New Kinase Matchmaker
• Photoactivated ATP analog is the first phosphorylation-dependent tool for mediating kinase-substrate cross-linking
• A Methyl Group Makes Us Complex
• Histone methylation recruits mRNA splicing machinery, helping explain how humans are so complex with relatively few genes
• Study Strengthens Alzheimer’s Link To Cholesterol
• Findings on the mechanism of a cholesterol metabolism pathway could aid development of new therapeutics
• Versatile Ketene Polymers
• Seldom-used ketene group is a useful addition to the growing list of functionalization strategies for polymer chemistry
• Chiral Sulfide Boosts Ylide Chemistry
• Inexpensive isothiocineole demonstrates high selectivity in asymmetric syntheses of epoxides and aziridines
• Exoplanet’s Methane Spotted From Hawaii
• A Mauna Kea infrared telescope detects gases in the atmosphere of a distant planet­­––a first from Earth’s surface

February 1, 2010

Science In Orbit(Member Content)

(February 1, 2010 | Vol. 88 Issue 5 | pp. 32-33)

The future of research on the International Space Station is up in the air.

Fluorochemicals Go Short

(February 1, 2010 | Vol. 88 Issue 5 | pp. 12-17)

Shorter perfluoroalkyl chain lengths improve environmental profile of versatile stain-, grease-, and water-repelling chemical.

Fluorinase Success

(February 1, 2010 | Vol. 88 Issue 5 | p. 7)

Biosynthesis: In a chemical first, an engineered microbe yields a bioactive fluorinated compound.

Tungsten Breaks Tough Bond

(February 1, 2010 | Vol. 88 Issue 5 | p. 10)

Organometallics: Rare carbon-carbon bond scission could lead to new route for functionalizing aromatics.

Medication On Demand

(February 1, 2010 | Vol. 88 Issue 5 | p. 10)

Drug Delivery: Electric field spurs nanoscale device to release cargo.

One-Pot Biodiesel

(February 1, 2010 | Vol. 88 Issue 5 | p. 11)

Synthetic Biology: Bacteria make biodiesel directly from glucose and hemicellulose.

Science & Technology Concentrates (Member Content)

(February 1, 2010 | Vol. 88 Issue 5 | pp. 30-31)

• Foil And Tape Serve Raman
• Pastelike silver dendrites generated on aluminum foil and transferred to Scotch tape serves as a substrate for SERS
• Magnetically Probed Protein Interactions
• The weak magnetosensitivity of photoinduced radical pairs can serve as a spectroscopic probe of protein-substrate interactions
• Aromatic Silicon Analog For Benzene
• Chemists synthesize the first aromatic hexasilabenzene isomer, and it has uneven “dismutational aromaticity”
• Newly Found Enzyme Degrades 8-Oxoguanine
• A deaminase that converts 8-oxoG to uric acid helps explain what might happen to 8-oxoG after it is excised during DNA repair
• Convenient Access To Thorium Chemistry
• A trio of new anhydrous complexes boosts thorium’s prospects in catalysis, materials science, and as a nuclear fuel
• Tiny Features Keep Termite Wings Dry
• Star-shaped microstructures and tiny hairs with nanoscale ridges wick away water to keep the insects flying
• Helical Polymers Under Stereocontrol
• Attaching chiral pendant groups to a polyphenylacetylene backbone allows reversible control over the polymer chain’s handedness
• Cascade Reaction To Crowded Carbons
• Palladium-mediated cut-and-paste reaction forges adjacent quaternary and tertiary stereocenters

January 25, 2010

Attacking Amyloids(Member Content)

(January 25, 2010 | Vol. 88 Issue 4 | pp. 30-32)

Proteomic analysis of peripheral cells reveals aspects of psychiatric disorder.

Clarifying Surface Catalysis(Member Content)

(January 25, 2010 | Vol. 88 Issue 4 | pp. 34-35)

Advances in computational modeling of molecule-surface processes reveal details of reactions.

What's That Stuff? Hand Warmers

(January 25, 2010 | Vol. 88 Issue 4 | pp. 36)

Small packets of warmth work through a simple exothermic reaction.

Printing On The Nanoscale

(January 25, 2010 | Vol. 88 Issue 4 | p. 9)

Nanotechnology: Method exploits electrified liquid jets for high-resolution patterning.

Ebola's Clever Cloak

(January 25, 2010 | Vol. 88 Issue 4 | p. 10)

Structural Biology: Protein that hides viral RNA prevents immune system's detection of deadly virus.

Science & Technology Concentrates (Member Content)

(January 25, 2010 | Vol. 88 Issue 4 | pp. 28-29)

• Hydrogel Of Many Talents
• Potential replacement for plastic is not only easy to make and mold but also heals itself when cut
• Simple Solution Disinfects Broadly
• Concoction can rid surfaces of prions, bacteria, fungi, and viruses
• Steps To St. John’s Wort Factor
• Diels-Alder reaction anchors synthesis of ent-hyperforin, enantiomer of key component in St. John’s wort
• Nanowire Arrays Map Neural Circuits
• High resolution method reveals electrical connections in the brain
• Membrane Structure Changes Before Lipid Domains Form
• Mass spec imaging provides a window into cell membranes
• Small Molecules Light Up Gene Expression
• Technique may aid study of gene expression patterns in cells and tissues
• Maternal Drinking Alters Child’s DNA
• Moderate consumption during pregnancy causes epigenetic changes that persist into adulthood
• Zebrafish Aid Drug Development
• Zebrafish help drug designers sort out structure-activity relationships among candidates

January 18, 2010

A Systemic Look At Schizophrenia

(January 18, 2010 | Vol. 88 Issue 3 | p. 26)

Proteomic analysis of peripheral cells reveals aspects of psychiatric disorder.

Sex Therapy Lead From Bird Brains(Member Content)

(January 18, 2010 | Vol. 88 Issue 3 | p. 27)

Reproductive hormone previously detected in birds, rats, and fish has now been found in humans.

New Way To 'Fix' CO₂

(January 18, 2010 | Vol. 88 Issue 3 | p. 6)

Electrocatalysis: Process converts CO₂ in air into the useful organic feedstock oxalate.

Finding Green In Gold

(January 18, 2010 | Vol. 88 Issue 3 | p. 9)

Materials: Precious metal in nanostructured form mediates oxidations selectively.

Chemotaxis

(January 18, 2010 | Vol. 88 Issue 3 | p. 9)

Acidic droplet solves maze.

Science & Technology Concentrates (Member Content)

(January 18, 2010 | Vol. 88 Issue 3 | pp. 24-25)

• Graphene Nanogaps For DNA
• A narrow gap in a graphene sheet attached to gold electrodes has been proposed as a means to sequence DNA
• Key Nutrients Decline In Transgenic Rice
• Genetic modifications aimed at improving pest resistance have unintended consequences
• Twisted Nature Of Transition States
• The long-held adage that enzymes stabilize a reactant’s transition state to speed up reactions may not be universally true
• New And Improved Cross-Couplings
• Chemists achieve cross-couplings of aryl and alkyl halides without a stoichiometric organometallic reagent
• Iron Uptake By Plankton Decreases As Oceans Acidify
• Lab studies pinpoint a potentially important biogeochemical change related to increasing CO₂ levels
• Porous Compounds Probed With Positrons
• Electron-Positron annihilation provides a better view of pore structure and defects in metal-organic frameworks
• A Nonacene With Staying Power
• Arylthio groups stabilize fused aromatic ring compounds, improving their prospects as organic semiconductors
• Flexible Drug Target Reveals Its Secrets
• Crystal structure helps elucidate the conformational flexibility of enzymes, offering new insights for designing drugs

January 11, 2010

China Ascendant

(January 11, 2010 | Vol. 88 Issue 2 | pp. 35-37)

Measured by patent applications or journal articles, growth in Chinese scientific output is stupendous.

Tools For Foreign Authors

(January 11, 2010 | Vol. 88 Issue 2 | p. Web Exclusive)

Manuscript-polishing services multiply as more authors aim to publish in English-language journals.

Finally, Palau'amine

(January 11, 2010 | Vol. 88 Issue 2 | p. 5)

Organic Synthesis: Ring formation anchors landmark conquest of complex marine natural product.

Paper About Reactome Array Stirs Controversy

(January 11, 2010 | Vol. 88 Issue 2 | p. 7)

Interdisciplinary Research: Work on a sensitive new array describes chemistry that experts see as unclear at best.

Gilded Graphene

(January 11, 2010 | Vol. 88 Issue 2 | p. 8)

Materials: Gold coat and microscopy methods offer new way to see and analyze atoms-thick carbon sheets.

Science & Technology Concentrates (Member Content)

(January 11, 2010 | Vol. 88 Issue 2 | pp. 33-34)

• Molecular Donut And Its Hole
• A Mo₃₆ cluster serves as a structure-directing template for formation of a spherical Mo₁₅₀ cluster.
• Human Blueprint Contains Code From Surprise Viral Source
• A previously unknown source of viral genetic code infiltrated our genome about 40 million years ago.
• Selenium’s Role In Mercury’s Toxicity
• Structure and binding study shows that Mercury’s “selenophilicity” is greater than its “thiophilicity”.
• Ubiquitin Unfolds Doomed Proteins
• Besides tagging proteins for destruction, ubiquitin also assists in the process by helping unfold the proteins.
• Speedy Nonlinear Optical Analysis
• Combining novel laser-probe method with fast statistical evaluation speeds up thin-film analysis.
• Atom Versus Superatom
• A photoelectron imaging spectroscopy study finds that periodic trends can predict molecules that behave like single atoms.
• Infectious Prions Mutate Structurally
• Researchers have discovered that misfolded prions can refold, suggesting a new approach to drug design.
• Clay-Polymer Nanolayers Improve Gas-Barrier Films
• A composite composed of alternating nanolayers could better protect electronics, food, and pharmaceuticals.

January 4, 2010

Fake Pharmaceuticals

(January 4, 2010 | Vol. 88 Issue 1 | pp. 27-29)

Those fighting against counterfeit medicines face increasingly sophisticated adversaries.

Dirt Tells Resistance Tale

(January 4, 2010 | Vol. 88 Issue 1 | p. 10)

Environmental Chemistry: Antibiotic resistance genes in soil are increasing.

Titania's Prowess

(January 4, 2010 | Vol. 88 Issue 1 | p. 11)

Catalysis: Gold's surprising reactivity may be partly due to oxide support.

Science & Technology Concentrates (Member Content)

(January 4, 2010 | Vol. 88 Issue 1 | pp. 25-26)

• Biocontainer Transport
• A polysaccharide molecular container encapsulates a nanotube as cargo and uses myosin to truck it along an actin highway in cells.
• Colloidal Lenses Turn Up The Heat
• Spherical colloidal particles in combination with temperature-sensitive objectives function as lenses for single-molecule imaging.
• Better View Of Solid-State Reactions
• Using nanocrystals suspended in water, researchers probe the properties solid-state organic reactions using solution spectroscopy techniques.
• Two-Faced Catalyst
• Novel design permits tandem aqueous- and organic-phase reactions in a biphasic solvent system.
• Flu-Fighting Proteins
• Interferon-inducible transmembrane proteins serve as the body's first line of defense against the H1N1 virus.

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